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Development of AEZS-115 (ZEN-019) by Optimization of Structurally Unique, Orally Active, Peptidomimetic GnRH Antagonists

  • K. W. Paulini
  • S. Baasner
  • M. Gerlach
  • E. E. Polymeropoulos
  • P. Schmidt
  • T. Schuster
  • M. Teifel
  • E. G. Guenther
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Luteinizing Hormone Benign Prostate Hyperplasia Precocious Puberty GnRH Antagonist Metabolic Stability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank A. Bork, R. Eckhard, B. Heil, A. Hofmann, E. Jaschob, B. Krönert, T. Kynast, C. Lang, A. Linsner, G. Müller, J. Schumann and K. Zimmermann for excellent technical assistance.

References

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    Soederhaell, J.A., et al., Biochem. and Biophys. Res. Commun. 333(2), 568–582 (2005).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K. W. Paulini
    • 1
  • S. Baasner
    • 1
  • M. Gerlach
    • 1
  • E. E. Polymeropoulos
    • 1
  • P. Schmidt
    • 1
  • T. Schuster
    • 1
  • M. Teifel
    • 1
  • E. G. Guenther
    • 1
  1. 1.Discovery and Preclinical DevelopmentÆterna Zentaris GmbHFrankfurt am MainGermany

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