Factors that Affect Dissociation Degree of Strong Aggregated Peptide Chains when Bound to a Polymer or Free in Solution

  • Luciana Malavolta
  • Clóvis R. Nakaie
Part of the Advances in Experimental Medicine and Biology book series (volume 611)


In a conceptual departure from the innumerable approaches that have been applied for studying solute-solvent interaction, we have focused on examining the solvation effect of polymeric material attaching or not peptide chains selected as solute models in their interactions with different solvent systems [1]. As one of the consequences of these studies, the sum (1:1) of the Gutmann´s electron acceptor (AN) and electron donor (DN) values [2] was previously proposed as a novel polarity parameter [3]. Following with these investigations, the search for rules which might govern solubilization processes of peptide sequences in solution has already been initiated [4, 5]. The present report has aimed to further evaluate the dissociation phenomenon of peptide sequences (attached or not to a solid support) having different levels of propensity to aggregation, some of them of physiological relevance.

Results and Discussion

  1. i)

    Dissocitation of peptide chains attached to resins: the...


Electron Paramagnetic Resonance Peptide Chain Great Solubilization Chaotropic Agent Chain Association 
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Grants from the Brazilian FAPESP and CNPq agencies are gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of BiophysicsUniversidade Federal de São PauloSao PauloBrazil

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