Factors that Affect Dissociation Degree of Strong Aggregated Peptide Chains when Bound to a Polymer or Free in Solution
In a conceptual departure from the innumerable approaches that have been applied for studying solute-solvent interaction, we have focused on examining the solvation effect of polymeric material attaching or not peptide chains selected as solute models in their interactions with different solvent systems . As one of the consequences of these studies, the sum (1:1) of the Gutmann´s electron acceptor (AN) and electron donor (DN) values  was previously proposed as a novel polarity parameter . Following with these investigations, the search for rules which might govern solubilization processes of peptide sequences in solution has already been initiated [4, 5]. The present report has aimed to further evaluate the dissociation phenomenon of peptide sequences (attached or not to a solid support) having different levels of propensity to aggregation, some of them of physiological relevance.
Results and Discussion
Dissocitation of peptide chains attached to resins: the...
KeywordsElectron Paramagnetic Resonance Peptide Chain Great Solubilization Chaotropic Agent Chain Association
Grants from the Brazilian FAPESP and CNPq agencies are gratefully acknowledged.