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Factors that Affect Dissociation Degree of Strong Aggregated Peptide Chains when Bound to a Polymer or Free in Solution

  • Luciana Malavolta
  • Clóvis R. Nakaie
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

In a conceptual departure from the innumerable approaches that have been applied for studying solute-solvent interaction, we have focused on examining the solvation effect of polymeric material attaching or not peptide chains selected as solute models in their interactions with different solvent systems [1]. As one of the consequences of these studies, the sum (1:1) of the Gutmann´s electron acceptor (AN) and electron donor (DN) values [2] was previously proposed as a novel polarity parameter [3]. Following with these investigations, the search for rules which might govern solubilization processes of peptide sequences in solution has already been initiated [4, 5]. The present report has aimed to further evaluate the dissociation phenomenon of peptide sequences (attached or not to a solid support) having different levels of propensity to aggregation, some of them of physiological relevance.

Results and Discussion

  1. i)

    Dissocitation of peptide chains attached to resins: the...

Keywords

Electron Paramagnetic Resonance Peptide Chain Great Solubilization Chaotropic Agent Chain Association 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Grants from the Brazilian FAPESP and CNPq agencies are gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of BiophysicsUniversidade Federal de São PauloSao PauloBrazil

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