Advertisement

Discovery of a Ligand that Compensates for Decreased Endogenous Agonist Potency of Melanocortin-4 Receptor Polymorphisms Identified in Obese Humans

  • Carrie Haskell-Luevano
  • Zhimin Xiang
  • Andrzej M. Wilczynski
  • Kimberly R. Haskell
  • Amy M. Andreasen
  • Sally A. Litherland
  • William J. Millard
  • Ira D. Pogozheva
  • Henry I. Mosberg
  • Nicholas B. Sorenson
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Melanocortin Receptor Peptide Agonist Normal Weight Control Agonist Potency Receptor Pharmacology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work has been supported by NIH Grants to CHL(DK063974, DK57080, DK64250) and to HIM (DA003910) and an ADA Research Award (CHL).

References

  1. 1.
    Xiang et al. Biochemistry. 45, 7277–7288 (2006).CrossRefGoogle Scholar
  2. 2.
    Wilcxynaki et al. J.Med.Chem. 47, 2194–2207 (2004).CrossRefGoogle Scholar
  3. 3.
    Wilczynski et al. J.Med.Chem. 48, 3060–3075 (2005).CrossRefGoogle Scholar
  4. 4.
    Jackson et al. Peptides. 26, 1978–1987 (2005).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Carrie Haskell-Luevano
    • 1
  • Zhimin Xiang
    • 1
  • Andrzej M. Wilczynski
    • 1
  • Kimberly R. Haskell
    • 1
  • Amy M. Andreasen
    • 1
  • Sally A. Litherland
    • 2
  • William J. Millard
    • 3
  • Ira D. Pogozheva
    • 4
  • Henry I. Mosberg
    • 4
  • Nicholas B. Sorenson
    • 1
  1. 1.Departments of Medicinal ChemistryUniversity of FloridaGainesvilleUSA
  2. 2.University of MichiganPahtology, Immunology and Laboratory MedicineAnn ArborUSA
  3. 3.PharmacodynamicsUniversity of FloridaGainesvilleUSA
  4. 4.Department of Medicinal ChemistryUniversity of MichiganAnn ArborUSA

Personalised recommendations