Inhibition of pathogenically-related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors
Signal transduction pathways are typically regulated by protein—protein interaction networks. As many human diseases exhibit dysfunctional aspects in these networks, there has been a great deal of enthusiasm for the prospect of identifying novel drug candidates targeting key signal transduction components in human diseases.
Candida albicans is an opportunistic fungal pathogen that is the cause of most “yeast infections” or candidiasis in humans. The pathogenicity of C. albicans is contingent upon its ability to switch from yeast to hyphal growth in response to environmental signals. Invasive hyphal growth requires signal transduction through the interaction of Candida Cdc42 (CaCdc42), a small GTPase of the Rho-family, with the CRIB (Cdc42/Rac Interactive Binding) domains of its two downstream effectors, Cst20 and CaCla4, under all conditions examined . Thus, these protein-protein interactions are potential targets for curbing candidiasis and that the CRIB peptides may...
KeywordsCandida Albicans Hyphal Growth Peptide Concentration Morphologic Transition Hyphal Cell
This work was supported in part by a Genomics and Health Initiative of the National Research Council of Canada (NRCC Pulbication No. 49514), sponsored by the Government of Canada.
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