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The Effects of the EW — Peptide Optical and Chemical Isomers on the Hemopoietic Stem Cells in Intact and Irradiated Mice

  • Vladislav I. Deigin
  • Tamara N. Semenets
  • Irina A. Zamulaeva
  • Yana V. Maliutina
  • Elena I. Selivanova
  • Alexander S. Saenko
  • Olga V. Semina
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

The influence of Glu-Trp (EW) synthetic dipeptide isomers on hemopoietic stem cells and basic immune response reactions is determined by their optical and chemical properties. L-amino acid containing dipeptides lE-lW (l-l) and l-γiE-lW (γ-l-l) have no effect on proliferation of intact bone marrow cells. The optical isomerism of the Glu residue is the essential determinant of the EW dipeptides biological activity. The inversion of the amino acid optical form imparts suppressor properties: dE-dW (d-d), d-γE-dW (γ-dd), dE-lW (d-l) and d-γE-lW (γ-d-l) inhibit proliferation of hemopoietic stem cells in intact bone marrow. The type of the peptide bond between l-Glu and Trp is another important factor for the biological activity of the l-Glu-containing peptides. Unlike lE-dW (l-d) with α-peptide bond, the dipeptide l-γE-dW (γ-l-d) with γ-peptide bond stimulates CFU-S-8 proliferation in intact bone marrow. In animals, pre-irradiationinjection of dE-dW (d-d), d-γE-dW (γ-d-d),...

Keywords

Hemopoietic Stem Cell Donor Mouse Constituent Amino Acid Hemopoietic Progenitor Inject Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Deigin V.I., Poverenny A.M., Semina O.V. and Semenets T.N. Immunol. Lett 67, 1: 41–46 (1999)CrossRefGoogle Scholar
  2. 2.
    Deigin V.I., Semenets T.N., Zamulaeva I.A, Maliutina Ya.V., Selivanova E.I, Saenko A.S, Semina O.V. Int. Immunopharmacol., 7, 375–382 (2007)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Vladislav I. Deigin
    • 1
    • 3
  • Tamara N. Semenets
    • 2
  • Irina A. Zamulaeva
    • 2
  • Yana V. Maliutina
    • 2
  • Elena I. Selivanova
    • 2
  • Alexander S. Saenko
    • 2
  • Olga V. Semina
    • 2
  1. 1.Department of peptide chemistryShemyakin and Ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia
  2. 2.Medical Radiological Research Center, RAMSObninskRussia
  3. 3.Immunotech Developments Inc.MississaugaCanada

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