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Design of Hetero-Bivalent Polypeptides as Kinetics-Based Sensors for High-Sensitivity Detection of Weak Molecular Interactions

  • Kenji Tonan
  • Dmitri Tolkatchev
  • Ping Xu
  • Ping Wang
  • Josee Plamondon
  • Anna Vinogradova
  • Richard Gingras
  • Feng Ni
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Multivalent System Dissociation Pathway Competitive Displacement Free Peptide Human Thrombin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Huskens, J., et al. J. Am. Chem. Soc. 126, 6784–6787 (2004).CrossRefGoogle Scholar
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    Zhou. H. X. J. Mol. Biol. 329, 1–8 (2003).CrossRefGoogle Scholar
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    Filfil, R., et al. in preparation.Google Scholar
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    DiMaio, J., et al. J. Biol. Chem.. 265, 21698–21703 (1990).Google Scholar
  5. 5.
    Anderson, P. J., et al. J. Biol.Chem. 275, 116428–16434 (2000).Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kenji Tonan
    • 1
  • Dmitri Tolkatchev
    • 1
  • Ping Xu
    • 1
  • Ping Wang
    • 1
  • Josee Plamondon
    • 1
  • Anna Vinogradova
    • 1
  • Richard Gingras
    • 1
  • Feng Ni
    • 1
  1. 1.Biomolecular NMR and Protein Research Group, Biotechnology Research InstituteNational Research Council of CanadaMontrealCanada

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