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ε-Peptide Chimeras as Novel Antimicrobials

  • Yi-An Lu
  • Jin-Long Yang
  • James P. Tam
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

The prevalence of antibiotic resistance of bacterial pathogens requires development of new antibacterials to overcome this limitation. Our previous work has demonstrated that cationic antimicrobial peptides with unusual architecture are often resistant to proteolytic degradation [1]. An example is a cascade-type of dendrimeric peptide (RLYR)4K2K that shows high in vitro antibacterial activity. It contains a trilysine core (K2K) that radiates four tetrapeptide RLYR arms with its sequence derived from the repeating topological motif of a known and potent antimicrobial peptide, protegrin-1 [2].

Here we report our continuing effort in developing new antimicrobial peptides with novel branched architecture using the s-amine of lysine for the ε-peptide backbone and functionalized α-amines as pendant side chains to give a branched α,ε-peptide containing two RLYR motifs. Since ε-peptides are found naturally as poly-ε-lysines which are generally stable to proteolytic enzymes, but...

Keywords

Antimicrobial Peptide Radial Diffusion Cationic Antimicrobial Peptide Extended Strand Straight Forward Manner 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The work was in part supported by US public Health Service NIH Grant EB001986.

References

  1. 1.
    Tam, J. P., Lu, Y-A. and Yang J-L. Eur. J. Biochem. 269, 923–932 (2002).CrossRefGoogle Scholar
  2. 2.
    Fahrner, R. L., et al. Chem. Biol. 3, 543–550 (1996).CrossRefGoogle Scholar
  3. 3.
    Shima, S., et al. J. Antibiotics 37, 1449–1455 (1984).CrossRefGoogle Scholar
  4. 4.
    Lehrer, R. L., et al. J. Immunol. Med. 137, 167–173 (2000).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yi-An Lu
    • 1
  • Jin-Long Yang
    • 2
  • James P. Tam
    • 1
  1. 1.Department of BiochemistryThe Scripps Research InstituteJupiterUSA
  2. 2.Vanderbilt Eye InstituteVanderbilt UniversityNashvilleUSA

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