Progress toward Total Solid-Phase Synthesis of Depsipeptide Antibiotic Katanosin B
The peptidoglycan synthesis pathway is an attractive target for antibacterial and antifungal agents in terms of specificity for microorganisms. Drugs with different mode of action from vancomycin should be promising candidates against vancomycin resistant strains. Katanosin B is naturally occurring cyclic depsipeptide antibiotic isolated from strain related to the genus Cytophaga.1According to recent literature data it inhibits transglycosylation and transpeptidation steps of bacterial cell wall biosynthesis by an unidentified mechanism that differs from those of vancomycin. Katanosin B is composed of eleven amino acids from which nine form cyclic structure joined with one ester linkage. In addition, this antibiotic contains three unusual L-β-hydroxy amino acids: phenylserine (PhSer), hydroxyleucine (HyLeu) and hydroxyasparagine (HyAsn). Lack of commercial sources of katanosin B producing organism PBJ-5356 and, particularly, unlimited access to its synthetic analogs...
KeywordsBenzyl Alcohol Active Charcoal Unusual Amino Acid Eleven Amino Acid Important Natural Product
The work was funded by an AHA-SDG grant (0630175N) to P. Cudic.