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Lipodepsipeptide antibiotic fusaricidin and its analogues. Total solid-phase and biological activity.

  • Maciej Stawikowski
  • Pedrag Cudic
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Infectious diseases due to antibiotic-resistant bacteria pose a serious threat to public health [1]. The Centers for Disease Control and Prevention has estimated that nearly two million people a year in the U.S. develop nosocomial infections, and nearly 90,000 of those people die. For the past three decades the antibiotic vancomycin has been the last line of defense against bacterial strains that are resistant to most of antibiotics. However, the utility of this drug has been limited because of the emergence of vancomycin-resistant bacterial strains, most notably in enterococcal and staphylococcal nosocomial pathogens. Therefore, developing new antibiotics capable of treating infections from drug-resistant bacteria is of vital importance.

Promising candidate for reverting multi-drug resistant bacteria is naturally occurring cyclic lipodepsipeptide antibiotic fusaricidin A. This natural product was isolated from Bacillus polymyxaKT-8 strain, and exhibits strong activity...

Keywords

Hemolytic Activity Bacillus Polymyxa Lipid Tail Cyclic Depsipeptide Ester Bond Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by NIH (1S06-GM073621-01) and AHA (0630175N) grants to P. Cudic.

References

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    Lipsitch, M. Trends in Microbiology, 9, 438–1444 (2001)CrossRefGoogle Scholar
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    Kajimura, Y., Kenda, M. J. Antibiot.. 49, 129–135 (1996)CrossRefGoogle Scholar
  3. 3.
    Stawikowski, M., Cudic. P. Tetrahedron Lett. 47, 8587–8590 (2006)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maciej Stawikowski
    • 1
  • Pedrag Cudic
    • 1
  1. 1.Department of Chemistry and BiochemistryFlorida Atlantic UniversityBoca RatonUSA

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