Synthesis and Application of (Z)-Alkene- and (E)-Fluoroalkene-Dipeptide Isosteres as cis-Amide Equivalents
KeywordsBenzoic Acid Peptide Bond Agonistic Activity Trans Conformation Peptide Derivative
We thank Takeda Pharmaceutical Company Limited for the biological activity evaluation of a series of compounds. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and Health and Labour Sciences Research Grants (Research on HIV/AIDS). K.T., T.N. and A.N. are grateful for Research Fellowships from the JSPS for Young Scientists.