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Synthesis and Application of (Z)-Alkene- and (E)-Fluoroalkene-Dipeptide Isosteres as cis-Amide Equivalents

  • Kenji Tomita
  • Tetsuo Narumi
  • Ayumu Niida
  • ya Oishi
  • Hiroaki Ohno
  • Nobutaka Fujii
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Keywords

Benzoic Acid Peptide Bond Agonistic Activity Trans Conformation Peptide Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank Takeda Pharmaceutical Company Limited for the biological activity evaluation of a series of compounds. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and Health and Labour Sciences Research Grants (Research on HIV/AIDS). K.T., T.N. and A.N. are grateful for Research Fellowships from the JSPS for Young Scientists.

References

  1. 1.
    Niida, A., Tomita, K., Mizumoto, M., Tanigaki, H., Terada, T., Oishi, S., Otaka, A., Inui, K. and Fujii, N. Org. Lett. 8, 613–616 (2006).CrossRefGoogle Scholar
  2. 2.
    Tomita, K., Niida, A., Oishi, S., Ohno, H., Cluzeau, J., Navenot, J.-M., Wang, Z., Peiper, S. C. and Fujii, N. Bioorg. Med. Chem. 14, 7595–7603 (2006).CrossRefGoogle Scholar
  3. 3.
    Tomita, K., Narumi, T., Niida, A., Oishi, S., Ohno, H. and Fujii, N. Biopolymers 88, 272–278 (2007).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kenji Tomita
    • 1
  • Tetsuo Narumi
    • 1
  • Ayumu Niida
    • 1
  • ya Oishi
    • 1
  • Hiroaki Ohno
    • 1
  • Nobutaka Fujii
    • 1
  1. 1.Kyoto University Sakyo-kuGraduate School of Pharmaceutical SciencesKyotoJapan

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