Rationally-designed Multivalent Architectures for Mimicking Homotrimers of CD40L, a Member of the TNF Superfamily
Ligands and receptors of the TNF superfamilies play a central role in the organization and function of the immune system . Ligands of the TNF-family, share a common structural motif. Monomers self-assemble around a three-fold symmetry axis to form non-covalent homotrimers that can each bind three receptor molecules. Interaction between CD40, a member of the TNF receptor superfamily, and its ligand CD40L, a 39 kDa glycoprotein is essential for the development of humoral and cellular immune responses. Selective blockade or activation of this pathway provides the ground for the development of new treatments against immunologically based-diseases and malignancies.
KeywordsHexanoic Acid CD40 Binding Amino Hexanoic Acid Mouse Dendritic Cell Central Scaffold
This work was supported by the CNRS, the Ministère de la Recherche (ACI « Jeunes Chercheurs »), « La Ligue contre le Cancer » and INCA. WS and SW were supported by grants from the Minist籥 de la Recherche and from the Fondation pour la Recherche Médicale (FRM). NT was supported by « La Ligue contre le Cancer »
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