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Vaccine Delivery: Synthesis and Investigation of a Highly Pure, Multi-Epitopic Lipopeptide Vaccine Candidate

  • Istvan Toth
  • Peter M. Moyle
  • Pavla Simerska
  • Yoshio Fujita
  • Colleen Olive
  • Michael F. Good
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Traditional vaccine development approaches (e.g. live attenuated or killed microorganisms) have produced many effective/successful vaccines. Numerous diseases exist, however, for which these methods are not suitable. Peptide vaccines, incorporating appropriate immunogenic epitopes, have advantages over traditional vaccines including a reduced risk of adverse effects, and the capacity to focus immune responses towards important antigens. In general, peptide vaccines stimulate poor or no immune responses when administered on their own, necessitating their administration with powerful adjuvants [e.g. the highly toxic Freund's complete adjuvant (CFA)]. The conjugation of bacterial or synthetic lipids to peptide antigens has been demonstrated in human clinical trials [ 1] to be a potentially safe means to adjuvant peptide epitopes. The lipid core peptide (LCP)-system (Figure 1) [ 2], incorporating a lipid-based adjuvant, a carrier, and one or more peptide epitopes, has been...

Keywords

Sodium Dodecyl Sulfate Peptide Antigen Peptide Vaccine Glycine Residue Peptide Epitope 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was funded by the National Health & Medical Research Council (Australia), the National Heart Foundation (Australia), and the Prince Charles Hospital Foundation. PMM was funded by the Queensland Government's growing the smart state PhD funding scholarship.

References

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Istvan Toth
    • 1
  • Peter M. Moyle
    • 1
  • Pavla Simerska
    • 1
  • Yoshio Fujita
    • 1
  • Colleen Olive
    • 2
  • Michael F. Good
    • 2
  1. 1.School of Molecular and Microbial Sciencesthe University of QueenslandSt LuciaAustralia
  2. 2.Queensland Institute of Medical ResearchHerstonAustralia

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