Design and Synthesis of Cyclic Arodyn Analogues by Ring-Closing Metathesis (RCM) for Kappa Opioid Receptor (KOP) Antagonists

  • Wei-Jie Fang
  • Santosh S. Kulkarni
  • Thomas F. Murray
  • Jane V. Aldrich
Part of the Advances in Experimental Medicine and Biology book series (volume 611)


Adenylyl Cyclase Trans Isomer Vinyl Ether Cyclic Peptide Linear Peptide 
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The authors thank Dr. Jun Xie in Dr. Thomas Murray's laboratory for performing the pharmacological assays. This research was supported by grant R01 DA018832 from the National Institute on Drug Abuse.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Wei-Jie Fang
    • 1
  • Santosh S. Kulkarni
    • 1
  • Thomas F. Murray
    • 2
  • Jane V. Aldrich
    • 1
  1. 1.Department of Medicinal ChemistryUniversity of KansasLawrenceU.S.A.
  2. 2.Creighton UniversityDepartment of PharmacologyOmahaU.S.A.

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