Peptides for prolonging youth
Proteins and peptides play an important role in the skin health as cutaneous structural components, inhibitors, stimulating agents or regulators of biochemical processes in the skin. Small peptides are often responsible for a biochemical effect: they are either released from larger units by proteolysis or exposed as a partial sequence due to a conformational change.
Thrombospondin-1 (TSP), a high molecular weight glycoprotein, contains a tripeptide sequence -Arg-Phe-Lys- (RFK) which activates the transforming growth factor beta (TGF-beta),1,2 inducing the synthesis of extracellular matrix proteins.3
Results and Discussion Palm-Lys-Val-Lys-OH
Only a few experiments were necessary to show that the original sequence pattern basic, hydrophobic and basic amino acid is required for the efficacy of such substances. By maintaining this pattern, the most differing variations have been tried on the three individual amino acids as well as on the N- and C-terminus. Part of the...