Advertisement

Peptides for prolonging youth

  • Marc Heidl
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Proteins and peptides play an important role in the skin health as cutaneous structural components, inhibitors, stimulating agents or regulators of biochemical processes in the skin. Small peptides are often responsible for a biochemical effect: they are either released from larger units by proteolysis or exposed as a partial sequence due to a conformational change.

Thrombospondin-1 (TSP), a high molecular weight glycoprotein, contains a tripeptide sequence -Arg-Phe-Lys- (RFK) which activates the transforming growth factor beta (TGF-beta),1,2 inducing the synthesis of extracellular matrix proteins.3

Results and Discussion Palm-Lys-Val-Lys-OH

Only a few experiments were necessary to show that the original sequence pattern basic, hydrophobic and basic amino acid is required for the efficacy of such substances. By maintaining this pattern, the most differing variations have been tried on the three individual amino acids as well as on the N- and C-terminus. Part of the...

Keywords

Basic Amino Acid Clostridium Botulinum Muscle Cell Contraction Human Muscle Cell Wrinkle Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    J Lawler, J Cell Mol Med 6 1–12 (2002)CrossRefGoogle Scholar
  2. 2.
    JE Murphy-Ullrich and M Poczatek, Cytokine Growth Factor Rev 11 59–69 (2000)CrossRefGoogle Scholar
  3. 3.
    L Yin, A Morita and T Tsuji, J Invest Dermatol 120 703–705 (2003)CrossRefGoogle Scholar
  4. 4.
    M Heidl, D Imfeld, M Stöckli, H Ziegler, Poster at 23 rd IFSCC, Oct 24–28, 2004Google Scholar
  5. 5.
    D Imfeld, M Stöckli, M Heidl, H Ziegler, T Schreier, Poster at 24 rd IFSCC, Octob er 16–19, 2006.Google Scholar
  6. 6.
    JJ McArdle et al., J Pharmacol Exp Ther 289, 543–550 (1999)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Marc Heidl
    • 1
  1. 1.Pentapharm Ltd.Basel

Personalised recommendations