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An Appreciation of the Scientific Life and Achievements of Bruce Merrifield

  • Alexander R. Mitchell
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 611)

Introduction

Bruce Merrifield's scientific biography, “Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis,” provides a history of solid phase-peptide synthesis (SPPS) from 1959 to 1993 [1]. While many readers will be familiar with SPPS literature after 1963, the inclusion of unpublished material from Merrifield's early laboratory notebooks opens a fascinating window on the development of SPPS from the formulation of concept in 1959 (p. 56, ref. 1) to the synthesis of a tetrapeptide four years later [2]. This early period was characterized by slow progress interrupted by numerous setbacks that led Bruce to later record (p. 90, ref. 1): “At the end of the first two years the results were so poor, I wonder what made me think that this approach would ever succeed. But from the outset I had a strong conviction that this was a good idea, and I am glad that I stayed with it long enough”. Garland Marshall, Bruce's first graduate student...

Keywords

Amino Acid Insertion Laboratory Notebook Peptide Chemistry Nobel Committee Scientific Biography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This paper was prepared under the auspices of the U.S. Department of Energy by the University of California, Lawrence Livermore National Laboratory, under Contract No. W-7405-Eng-48.

References

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    Merrifield, B. Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis. American Chemical Society: Washington, DC, 1993.Google Scholar
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    Marshall, G. R. J. Pept. Sci. 9, 534–544 (2003).CrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Alexander R. Mitchell
    • 1
  1. 1.Energetic Materials CenterLawrence Livermore National Laboratory, University of CaliforniaLivermoreUSA

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