Word Design for DNA Computing

  • Zoya Ignatova
  • Karl-Heinz Zimmermann
  • Israel Martínez-Pérez


This chapter addresses the problem of negative word design negative word design: Construct a large set of oligonucleotides which selectively hybridize so that undesired molecules encoding false results or blocking the desired reactions are excluded. In practice, such a set of oligonucleotides is designed so that it simultaneously satisfies several thermodynamical and combinatorial constraints.


Block Code Edit Distance Word Design Reverse Complement Steiner System 
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Copyright information

© Springer-Verlag US 2008

Authors and Affiliations

  • Zoya Ignatova
    • 1
  • Karl-Heinz Zimmermann
    • 2
  • Israel Martínez-Pérez
    • 2
  1. 1.Cellular BiochemistryMax Planck Institute of BiochemistryMunichGermany
  2. 2.Institute of Computer TechnologyHamburg University of TechnologyGermany

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