Role of Signal-responsive Class IIa Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression

  • Brian Yee Hong Lam
  • Sangeeta Chawla


Histone deacetylases (HDACs) act as transcriptional repressors by catalyzing the deacetylation of lysine residues on the N-terminal tails of histones and altering chromatin structure. Mammalian HDACs are grouped into 3 classes, Class I, II, and III based on their homology to known yeast enzymes. The Class II HDACs comprise of two subgroups of Class IIa and Class IIb enzymes. Class IIa histone deacetylases are subject to signal-dependent intracellular trafficking, which has emerged as an important regulatory mechanism for controlling gene expression through associated transcription factors. This chapter reviews our current understanding of the regulation and function of class IIa HDACs in neuronal cells.


Histone Deacetylase Nuclear Export Serum Response Factor Cerebellar Granule Neuron Neuronal Gene Expression 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Brian Yee Hong Lam
  • Sangeeta Chawla

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