CREB-Dependent Transcription and Synaptic Plasticity

  • Angel Barco
  • Dragana Jancic
  • Eric R. Kandel


The CREB family of transcription factors are involved in controlling the transcriptional responses to a wide range of extracellular signals in neurons. In this chapter we discuss the role of the CREB pathway in synaptic plasticity. We first describe how learning-related stimuli, of different nature and intensity, can activate signaling pathways that converge on the induction of CRE-driven gene expression and how the nuclear response orchestrated by CREB can alter future synaptic activity. Second, we will discuss how CREB’s control of synaptic plasticity contributes to learning, memory and other complex brain function. Finally, we will briefly outline how dysfunction of this activation pathway can lead to psychiatric and neurological disorders.


Synaptic Plasticity cAMP Response Element Binding Inducible cAMP Early Repressor cAMP Response Element Binding Phosphorylation cAMP Response Element Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Angel Barco
  • Dragana Jancic
  • Eric R. Kandel

There are no affiliations available

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