L-type Channel Regulation of Gene Expression
Calcium-regulated transcription plays a key role in converting electrical activity at the membrane into long-lasting structural and biochemical changes in excitable cells. Although several calcium influx pathways contribute to the intracellular calcium rise that follows membrane depolarization in neurons, calcium influx through L-type calcium channels (LTCs) and NMDA receptors is particularly effective at activating gene expression. In this chapter, we review some of the experiments implicating LTCs in the induction of gene expression in response to neuronal activity and discuss some of the mechanisms that explain the dependence of activity-induced transcription on LTCs. We will focus our discussion on studies that explore the features of LTCs that allow them to activate the transcription factor CREB, and we will discuss recent studies from our group that identify the C-terminus of the LTC as a protein that regulates transcription directly in the nucleus.
KeywordsCREB Binding Protein Activate Gene Expression CREB Phosphorylation Serum Response Element Transcription Factor CREB
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