Puberty and Pediatric-Onset Inflammatory Bowel Disease

  • Barbara S. Kirschner
  • Barry H. Rich


Growth Hormone Inflammatory Bowel Disease Luteinizing Hormone Standard Deviation Score Final Height 
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  1. 1.
    Irwin CE Jr, Shafer M. Adolescent health problems. In: Harrison’s Principals of Internal Medicine. 14 ed. New York: McGraw Hill; 1998:30–3.Google Scholar
  2. 2.
    Pralong FP, Voirol M, Giacomini M, et al. Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regulatory Peptides 2000;95(1–3):47–52.PubMedCrossRefGoogle Scholar
  3. 3.
    Blogowska A, Rzepka-Gorska I, Krzyzanowska-Swiniarska B. Is neuropeptide Y responsible for constitutional delay of puberty in girls? A preliminary report. Gynecol Endocrinol 2004;19(1):22–5.PubMedCrossRefGoogle Scholar
  4. 4.
    Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L. Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med 1972;287(12):582–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Reiter EO, Fuldauer VG, Root AW. Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalities. J Pediatr 1977;90(5):766–70.PubMedCrossRefGoogle Scholar
  6. 6.
    Guercio G, Rivarola MA, Chaler E, Maceiras M, Belgorosky A. Relationship between the growth hormone/insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls. J Clin Endocrinol Metab 2003;88(3):1389–93.PubMedCrossRefGoogle Scholar
  7. 7.
    Brain CE, Savage MO. Growth and puberty in chronic inflammatory bowel disease. Bailliere’s Clinical Gastroenterology 1994;8(1):83–100.PubMedCrossRefGoogle Scholar
  8. 8.
    MacMahon B. Age at Menarche: United States, 1960–1970. Vital Health Statistics 11 1973;133:1–36.Google Scholar
  9. 9.
    Tanner JM, Davies PS. Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 1985;107(3):317–29.PubMedCrossRefGoogle Scholar
  10. 10.
    Frisch RE, Revelle R. Height and weight at menarche and a hypothesis of menarche. Arch Dis Child 1971;46(249):695–701.PubMedGoogle Scholar
  11. 11.
    Zacharias L, Rand WM, Wurtman RJ. A prospective study of sexual development and growth in American girls: the statistics of menarchie. Obstet & Gynecol Survey 1976;31(4):325–37.CrossRefGoogle Scholar
  12. 12.
    Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44(235):291–303.PubMedCrossRefGoogle Scholar
  13. 13.
    Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45(239):13–23.PubMedGoogle Scholar
  14. 14.
    Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51(3):170–9.PubMedGoogle Scholar
  15. 15.
    Tanner JM. Growth at Adolescence. 2 ed. Oxford: Blackwell Scientific Publications; 1962.Google Scholar
  16. 16.
    Schall JI, Semeao EJ, Stallings VA, et al. Self-assessment of sexual maturity status in children with Crohn disease. J Pediatr 2002;141(2):223–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Rapkin AJ, Tsao JC, Turk N, et al. Relationships among self-rated Tanner staging, hormones, and psychosocial factors in healthy female adolescents. J Pediatr Adoles Gynecol 2006;19(3):181–7.CrossRefGoogle Scholar
  18. 18.
    Hildebrand H, Karlberg J, Kristiansson B. Longitudinal growth in children and adolescents with inflammatory bowel disease. J Ped Gastroenterol Nutr 1994;18(2):165–73.Google Scholar
  19. 19.
    Karlberg J, Fryer JG, Engstrom I, et al. Analysis of linear growth using a mathematical model. II. From 3 to 21 years of age. Acta Paed Scand 1987;337:12–29.Google Scholar
  20. 20.
    Kanof ME, Lake AM, Bayless TM. Decreased height velocity in children and adolescents before the diagnosis of Crohn disease. Gastroenterology 1988;95(6):1523–7.PubMedGoogle Scholar
  21. 21.
    Kirschner BS. Growth and development in chronic inflammatory bowel disease. Acta Paed Scand 1990;366:98–104.Google Scholar
  22. 22.
    Saha MT, Ruuska T, Laippala P, et al. Growth of prepubertal children with inflammatory bowel disease. J Ped Gastroenterol Nutr 1998;26(3):310–4.CrossRefGoogle Scholar
  23. 23.
    Motil KJ, Grand RJ, Davis-Kraft L, et al. Growth failure in children with inflammatory bowel disease: a prospective study. Gastroenterology 1993;105(3):681–91.PubMedGoogle Scholar
  24. 24.
    Sentongo TA, Semeao EJ, Piccoli DA, et al. Growth, body composition, and nutritional status in children and adolescents with Crohn disease. J Pediatr Gastroenterol Nutr 2000;31(1):33–40.PubMedCrossRefGoogle Scholar
  25. 25.
    Sawczenko A, Ballinger AB, Savage MO, et al. Clinical features affecting final adult height in patients with pediatric-onset Crohn disease. Pediatrics 2006;118(1):124–9.PubMedCrossRefGoogle Scholar
  26. 26.
    Griffiths AM, Nguyen P, Smith C, et al. Growth and clinical course of children with Crohn disease. Gut 1993;34(7):939–43.PubMedCrossRefGoogle Scholar
  27. 27.
    Ferguson A, Sedgwick DM. Juvenile onset inflammatory bowel disease: height and body mass index in adult life. BMJ (Clinical research ed 1994;308(6939):1259–63.Google Scholar
  28. 28.
    Homer DR, Grand RJ, Colodny AH. Growth, course, and prognosis after surgery for Crohn disease in children and adolescents. Pediatrics 1977;59(5):717–25.PubMedGoogle Scholar
  29. 29.
    Kirschner BS, Uebler N, Sutton MM. Growth after menarche in pediatric patients with chronic inflammatory bowel disease. Gastroenterology 1993;104:A629.Google Scholar
  30. 30.
    Beumont PJ, George GC, Pimstone BL, Vinik AI. Body weight and the pituitary response to hypothalamic releasing hormones in patients with anorexia nervosa. The J Clin Endocrinol Metab 1976;43(3):487–96.Google Scholar
  31. 31.
    Ballinger AB, Camacho-Hubner C, Croft NM. Growth failure and intestinal inflammation. QJM 2001;94(3):121–25.PubMedCrossRefGoogle Scholar
  32. 32.
    Frisch RE. Fatness, menarche, and female fertility. Perspectives Biol Med 1985;28(4):611–33.Google Scholar
  33. 33.
    Frisch RE, Gotz-Welbergen AV, McArthur JW, et al. Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. JAMA 1981;246(14):1559–63.PubMedCrossRefGoogle Scholar
  34. 34.
    Frisch RE, Wyshak G, Vincent L. Delayed menarche and amenorrhea in ballet dancers. N Engl J Med 1980;303(1):17–19.PubMedCrossRefGoogle Scholar
  35. 35.
    Dreizen S, Spirakis CN, Stone RE. A comparison of skeletal growth and maturation in undernourished and well-nourished girls before and after menarche. J Pediatr 1967;70(2):256–63.PubMedCrossRefGoogle Scholar
  36. 36.
    Dreizen S, Stone R. Human Nutritive and Growth Failure. Postgrad Med 1962:381–6.Google Scholar
  37. 37.
    Kelts DG, Grand RJ, Shen G, et al. Nutritional basis of growth failure in children and adolescents with Crohn disease. Gastroenterology 1979;76(4):720–7.PubMedGoogle Scholar
  38. 38.
    Kirschner BS, Voinchet O, Rosenberg IH. Growth retardation in inflammatory bowel disease. Gastroenterology 1978;75(3):504–11.PubMedGoogle Scholar
  39. 39.
    Thomas AG, Taylor F, Miller V. Dietary intake and nutritional treatment in childhood Crohn disease. J Pediatr Gastroenterol Nutr1993;17(1):75–81.PubMedGoogle Scholar
  40. 40.
    Burnham JM, Shults J, Semeao E, et al. Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition. J Bone Miner Res 2004;19(12):1961–8.PubMedCrossRefGoogle Scholar
  41. 41.
    Kaplowitz P. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 2001;108:347–53.Google Scholar
  42. 42.
    Chong SK, Grossman A, Walker-Smith JA, et al. Endocrine dysfunction in children with Crohn disease. J Ped Gastroenterol Nutr 1984;3(4):529–34.CrossRefGoogle Scholar
  43. 43.
    Farthing MJ, Campbell CA, Walker-Smith J, et al. Nocturnal growth hormone and gonadotrophin secretion in growth retarded children with Crohn disease. Gut 1981;22(11):933–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Gotlin RW, Dubois RS. Nyctohemeral growth hormone levels in children with growth retardation and inflammatory bowel disease. Gut 1973;14(3):191–5.PubMedCrossRefGoogle Scholar
  45. 45.
    Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology 1986;91(4):830–6.PubMedGoogle Scholar
  46. 46.
    Tenore A, Berman WF, Parks JS, et al. Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease. J Clin Endocrinol Metab 1977;44(4):622–8.PubMedCrossRefGoogle Scholar
  47. 47.
    Corkins MR, Gohil AD, Fitzgerald JF. The insulin-like growth factor axis in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2003;36(2):228–34.PubMedCrossRefGoogle Scholar
  48. 48.
    Thomas AG, Holly JM, Taylor F, et al. Insulin like growth factor-I, insulin like growth factor binding protein-1, and insulin in childhood Crohn disease. Gut 1993;34(7):944–7.PubMedCrossRefGoogle Scholar
  49. 49.
    Yakar S, Liu JL, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Nat Acad Sci 1999;96(13):7324–9.PubMedCrossRefGoogle Scholar
  50. 50.
    Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 2001;131(11 Suppl):3109S–20S.PubMedGoogle Scholar
  51. 51.
    Azooz OG, Farthing MJ, Savage MO, et al. Delayed puberty and response to testosterone in a rat model of colitis. Am J Physiol 2001;281(5):R1483–91.Google Scholar
  52. 52.
    Wong SC, MacRae VE, McGrogan P, et al. The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation. J Pediatr Gastroenterol Nutr 2005;43:144–155.Google Scholar
  53. 53.
    Wang P, Li N, Li JS, et al. The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity. World J Gastroenterol 2002;8(3):531–6.PubMedGoogle Scholar
  54. 54.
    Denson LA, Menon RK, Shaufl A, et al. TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding. J Clin Invest 2001;107(11):1451–8.PubMedGoogle Scholar
  55. 55.
    Theiss AL, Fruchtman S, Lund PK. Growth factors in inflammatory bowel disease: the actions and interactions of growth hormone and insulin-like growth factor-I. Inflammatory Bowel Diseases 2004;10(6):871–80.PubMedCrossRefGoogle Scholar
  56. 56.
    Shafer M, Irwin C. The adolescent patient. In: Rudolph A, ed. Rudolph’s Pediatrics. 14 ed: Norwalk, Appleton and Lange; 1995.Google Scholar
  57. 57.
    Mamula P, Markowitz JE, Baldassano RN. Inflammatory bowel disease in early childhood and adolescence: special considerations. Gastroenterology Clin N Amer 2003;32(3):967–95.CrossRefGoogle Scholar
  58. 58.
    Nottelmann ED, Susman EJ, Inoff-Germain G, et al. Developmental processes in early adolescence: relationships between adolescent adjustment problems and chronologic age, pubertal stage, and puberty-related serum hormone levels. J Pediatr 1987;110(3):473–80.PubMedCrossRefGoogle Scholar
  59. 59.
    Consten D, Bogerd J, Komen J, et al. Long-term cortisol treatment inhibits pubertal development in male common carp, Cyprinus carpio L. Biology of Reproduction 2001;64(4):1063–71.PubMedCrossRefGoogle Scholar
  60. 60.
    Alperstein G, Daum F, Fisher SE, et al. Linear growth following surgery in children and adolescents with Crohn disease: relationship to pubertal status. J Pediatr Surg 1985;20(2):129–33.PubMedCrossRefGoogle Scholar
  61. 61.
    Allen DB, Julius JR, Breen TJ, Attie KM. Treatment of glucocorticoid-induced growth suppression with growth hormone. National Cooperative Growth Study. J Clin Endocrinol Metab1998;83(8):2824–9.PubMedCrossRefGoogle Scholar
  62. 62.
    Landon C, Rosenfeld RG. Short stature and pubertal delay in male adolescents with cystic fibrosis. Androgen treatment. Amer J Dis Child (1960) 1984;138(4):388–91.Google Scholar
  63. 63.
    Ballinger AB, Savage MO, Sanderson IR. Delayed puberty associated with inflammatory bowel disease. Pediatr Res 2003;53(2):205–10.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Barbara S. Kirschner
    • 1
  • Barry H. Rich
  1. 1.Section of Pediatric Gastroenterology, Hepatology & Nutrition, Department of PediatricsThe University of Chicago, The University of Chicago Comer Children’s HospitalChicagoUSA

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