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Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

  • Ho Chul Kang
  • Ted M. Dawson
  • Valina L. Dawson
Chapter

Abstract

Excitotoxicity is a common pathological process in many neurodegenerative disorders; and this process involves over-stimulation of glutamate receptors and an excessive influx of calcium into cells. Cell death in excitotoxicity is unique in that it does not involve caspase dependent pathways. Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) is an early pathological event in excitotoxicity that leads to a unique form of cell death called parthanatos. Biochemical events in parthanatos include early accumulation of poly (ADP-ribose) (PAR) and nuclear translocation of apoptosis inducing factor (AIF) from the mitochondria.

Keywords

Glutamate Receptor Induce Cell Death Apoptosis Induce Factor PARP Inhibitor Excessive Influx 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank K. Quinn Tyler for editorial assistance. This work was supported by USPHS NS039148, DA000266. TMD is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ho Chul Kang
    • 1
  • Ted M. Dawson
    • 1
  • Valina L. Dawson
    • 1
  1. 1.Institute For Cell EngineeringJohns Hopkins University School of MedicineBaltimoreUSA

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