Age-Dependence of Neuronal Apoptosis and of Caspase Activation

  • Denson G. Fujikawa


A widely accepted morphological classification of cell death divides it into three types: apoptosis, autophagy and necrosis. Research into the biochemical basis of cell death began with apoptosis, and in recent years the programmed mechanisms contributing to cell death and apoptosis became synonymous. This has created confusion, because “apoptosis” refers to a particular morphology and not to a biochemical pathway. Within the central nervous system, both naturally occurring and pathologically induced neuronal apoptosis occurs during the neonatal period in rodents, and becomes virtually undetectable in adult rodents. In the same way, the caspase-dependent programmed cell death pathways are also most prominent in neonatal rodents, and also disappear in adult rodents, although there are earlier studies to the contrary. In adult rodents, acute neuronal injury induces neuronal necrosis, which involves caspase-independent programmed cell death mechanisms.


Cerebral Ischemia Status Epilepticus Adult Rodent Lysosomal Cathepsin Flocculent Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Neurology DepartmentVA Greater Los Angeles Healthcare SystemNorth HillsUSA
  2. 2.Department of Neurology and Brain Research InstituteDavid Geffen School of Medicine, University of CaliforniaLos AngelesUSA

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