Abstract
Historically, cell death has been divided into two generic categories: apoptosis, which requires energy and in which the cell plays an active role, and necrosis, which occurs accidentally, does not require energy consumption and is considered as a passive, uncontrolled cell death program. Among the conceptually opposite cell death forms, apoptosis is the best understood. This death program has been defined as developmentally programmed and ordered cellular response. Apoptosis is initiated by cell rounding and subsequent detachment from the surrounding cells. Chromatin condenses into “crescent-like” forms abutting the inner nuclear membrane. Plasma membrane convolutes and gives rise to characteristic vesicles containing cellular organelles and cytoplasm, known as the “apoptotic bodies.” Apoptosis is generally not accompanied by inflammation since macrophages or neighbouring cells engulf the formed apoptotic bodies before the loss of plasma membrane integrity (Kerr et al. 1972). In contrast to apoptosis, necrosis is characterized by disruption of the plasma membrane with a subsequent water influx and leakage of cell content to the surroundings. Cell death by necrosis can elicit an inflammatory response (Edinger and Thompson 2004).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863–877
Adhami F, Schloemer A, Kuan CY (2007) The roles of autophagy in cerebral ischemia. Autophagy 3:42–44
Alford S, Frenguelli BG, Schofield JG, Collingridge GL (1993) Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors. J Physiol 469:693–716
Amadoro G, Ciotti MT, Costanzi M, Cestari V, Calissano P, Canu N (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci USA 103:2892–2897
Andrabi SA et al (2006) Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci USA 103:18308–18313
Andreyev AY, Fahy B, Fiskum G (1998) Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition. FEBS Lett 439:373–376
Araujo IM et al (2005) Proteolysis of NR2B by calpain in the hippocampus of epileptic rats. Neuroreport 16:393–396
Baggetto LG (1992) Deviant energetic metabolism of glycolytic cancer cells. Biochimie 74:959–974
Baines CP et al (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434:658–662
Bajt ML, Cover C, Lemasters JJ, Jaeschke H (2006) Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 94:217–225
Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120:483–495
Bano D et al (2005) Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 120:275–285
Barkla DH, Gibson PR (1999) The fate of epithelial cells in the human large intestine. Pathology 31:230–238
Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P (2005) Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 280:18558–18561
Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB (2004) Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J 18:1303–1305
Beaulaton J, Lockshin RA (1982) The relation of programmed cell death to development and reproduction: Comparative studies and an attempt at classification. Int Rev Cytol 79:215–235
Ben-Ari Y (2001) Cell death and synaptic reorganizations produced by seizures. Epilepsia 42(Suppl 3):5–7
Berger NA, Sims JL, Catino DM, Berger SJ (1983) Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells. Princess Takamatsu Symp 13:219–226
Boise LH, Collins CM (2001) Salmonella-induced cell death: Apoptosis, necrosis or programmed cell death? Trends Microbiol 9:64–67
Borst P, Rottenberg S (2004) Cancer cell death by programmed necrosis? Drug Resist Update 7:321–324
Bose I, Ghosh B (2007) The p53-MDM2 network: From oscillations to apoptosis. J Biosci 32:991–997
Boujrad H, Gubkina O, Robert N, Krantic S, Susin SA (2007) AIF-mediated programmed necrosis: A highly regulated way to die. Cell Cycle 6:2612–2619
Bras M et al (2007) Drp1 mediates caspase-independent type III cell death in normal and leukemic cells. Mol Cell Biol 27:7073–7088
Bredesen DE (2007) Key note lecture: Toward a mechanistic taxonomy for cell death programs. Stroke 38:652–660
Broker LE, Kruyt FA, Giaccone G (2005) Cell death independent of caspases: A review. Clin Cancer Res 11:3155–3162
Budd SL, Nicholls DG (1996) Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 67:2282–2291
Camacho A, Massieu L (2006) Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death. Arch Med Res 37:11–18
Cande C et al (2004) AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene 23:1514–1521
Cao X, Deng X, May WS (2003a) Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax. Blood 102:2605–2614
Cao G, Clark RS, Pei W, Yin W, Zhang F, Sun FY, Graham SH, Chen J (2003b) Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. J Cereb Blood Flow Metab 23:1137–1150
Cao G et al (2007) Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. J Neurosci 27:9278–9293
Cartron PF, Oliver L, Juin P, Meflah K, Vallette FM (2004) The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein. J Biol Chem 279:11503–11512
Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9:351–365
Chautan M, Chazal G, Cecconi F, Gruss P, Golstein P (1999) Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr Biol 9:967–970
Chen J, Liu X, Mandel LJ, Schnellmann RG (2001a) Progressive disruption of the plasma membrane during renal proximal tubule cellular injury. Toxicol Appl Pharmacol 171:1–11
Chen M, He H, Zhan S, Krajewski S, Reed JC, Gottlieb RA (2001b) Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion. J Biol Chem 276:30724–30728
Cheung EC et al (2005) Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 25:1324–1334
Chihab R, Oillet J, Bossenmeyer C, Daval JL (1998) Glutamate triggers cell death specifically in mature central neurons through a necrotic process. Mol Genet Metab 63:142–147
Chua BT, Guo K, Li P (2000) Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem 275:5131–5135
Clarke PG (1990) Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol (Berl) 181:195–213
Colbourne F, Sutherland GR, Auer RN (1999) Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J Neurosci 19:4200–4210
Cregan SP, Dawson VL, Slack RS (2004) Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 23:2785–2796
Cuerrier D, Moldoveanu T, Davies PL (2005) Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: The importance of primed side interactions. J Biol Chem 280:40632–40641
Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N (2005) Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci 25:10262–10272
Danial NN, Korsmeyer SJ (2004) Cell death: Critical control points. Cell 116:205–219
Dargusch R, Piasecki D, Tan S, Liu Y, Schubert D (2001) The role of Bax in glutamate-induced nerve cell death. J Neurochem 76:295–301
Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin SA, Zamzami N, Kroemer G (2000) Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 476:118–123
Dawson VL, Dawson TM (2004) Deadly conversations: Nuclear-mitochondrial cross-talk. J Bioenerg Biomembr 36:287–294
Delettre C, Yuste VJ, Moubarak RS, Bras M, Lesbordes-Brion JC, Petres S, Bellalou J, Susin SA (2006a) AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer. J Biol Chem 281:6413–6427
Delettre C, Yuste VJ, Moubarak RS, Bras M, Robert N, Susin SA (2006b) Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with nadh oxidase activity. J Biol Chem 281:18507–18518
Donovan N, Becker EB, Konishi Y, Bonni A (2002) JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery. J Biol Chem 277:40944–40949
Dubinsky JM, Levi Y (1998) Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons. J Neurosci Res 53:728–741
Dugan LL, Sensi SL, Canzoniero LM, Handran SD, Rothman SM, Lin TS, Goldberg MP, Choi DW (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-d-aspartate. J Neurosci 15:6377–6388
Dykens JA (1994) Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: Implications for neurodegeneration. J Neurochem 63:584–591
Edinger AL, Thompson CB (2004) Death by design: Apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16:663–669
Festjens N, Vanden Berghe T, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 1757:1371–1387
Fonfria E et al (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 143:186–192
Fonnum F, Lock EA (2004) The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: Exemplified with toxic effects on cerebellar granule cells. J Neurochem 88:513–531
Friberg H, Wieloch T (2002) Mitochondrial permeability transition in acute neurodegeneration. Biochimie 84:241–250
Fryer HJ, Knox RJ, Strittmatter SM, Kalb RG (1999) Excitotoxic death of a subset of embryonic rat motor neurons in vitro. J Neurochem 72:500–513
Fujikawa DG, Shinmei SS, Cai B (1999) Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats. Eur J Neurosci 11:1605–1614
Fujikawa DG, Shinmei SS, Cai B (2000a) Seizure-induced neuronal necrosis: Implications for programmed cell death mechanisms. Epilepsia 41(Suppl 6):S9–S13
Fujikawa DG, Shinmei SS, Cai B (2000b) Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: Implications for programmed cell death mechanisms. Neuroscience 98:41–53
Fukuda K, Yamamoto M (1999) Acquisition of resistance to apoptosis and necrosis by Bcl-xL over-expression in rat hepatoma McA-RH8994 cells. J Gastroenterol Hepatol 14:682–690
Gao G, Dou QP (2000) N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome c release and apoptotic cell death. J Cell Biochem 80:53–72
Gharibyan AL, Zamotin V, Yanamandra K, Moskaleva OS, Margulis BA, Kostanyan IA, Morozova-Roche LA (2007) Lysozyme amyloid oligomers and fibrils induce cellular death via different apoptotic/necrotic pathways. J Mol Biol 365:1337–1349
Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83:731–801
Golstein P, Kroemer G (2007) Cell death by necrosis: Towards a molecular definition. Trends Biochem Sci 32:37–43
Golstein P, Aubry L, Levraud JP (2003) Cell-death alternative model organisms: Why and which? Nat Rev Mol Cell Biol 4:798–807
Gozuacik D, Kimchi A (2007) Autophagy and cell death. Curr Top Dev Biol 78:217–245
Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309–1312
Haince JF, Rouleau M, Hendzel MJ, Masson JY, Poirier GG (2005) Targeting poly(ADP-ribosyl)ation: A promising approach in cancer therapy. Trends Mol Med 11:456–463
Han W, Li L, Qiu S, Lu Q, Pan Q, Gu Y, Luo J, Hu X (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6:1641–1649
Hans G et al (2005) Beta-carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway. Neuropharmacology 48:105–117
Heeres JT, Hergenrother PJ (2007) Poly(ADP-ribose) makes a date with death. Curr Opin Chem Biol 11:644–653
Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776
Hirt UA, Gantner F, Leist M (2000) Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms. J Immunol 164:6520–6529
Holcik M, Thompson CS, Yaraghi Z, Lefebvre CA, MacKenzie AE, Korneluk RG (2000) The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury. Proc Natl Acad Sci USA 97:2286–2290
Holler N et al (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489–495
Holt JA (1983) Cancer, a disease of defective glucose metabolism. Med Hypotheses 10:133–150
Hong SJ, Dawson TM, Dawson VL (2004) Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 25:259–264
Ikeda Y, Long DM (1990) The molecular basis of brain injury and brain edema: The role of oxygen free radicals. Neurosurgery 27:1–11
Ishihara N et al (2005) Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons. J Neurochem 95:1277–1286
Jaattela M (2002) Programmed cell death: Many ways for cells to die decently. Ann Med 34:480–488
Jaattela M, Tschopp J (2003) Caspase-independent cell death in T lymphocytes. Nat Immunol 4:416–423
Kehrer JP (1993) Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21–48
Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257
Kim GT, Chun YS, Park JW, Kim MS (2003a) Role of apoptosis-inducing factor in myocardial cell death by ischemia-reperfusion. Biochem Biophys Res Commun 309:619–624
Kim JS, He L, Lemasters JJ (2003b) Mitochondrial permeability transition: A common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 304:463–470
Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN, Bronson RT, Ackerman SL (2002) The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 419:367–374
Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96–99
Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH (2000) Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7:1166–1173
Krantic S, Mechawar N, Reix S, Quirion R (2005) Molecular basis of programmed cell death involved in neurodegeneration. Trends Neurosci 28:670–676
Krantic S, Mechawar N, Reix S, Quirion R (2007) Apoptosis-inducing factor: A matter of neuron life and death. Prog Neurobiol 81:179–196
Kroemer G et al (2005) Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 12(Suppl 2):1463–1467
Krysko DV, Denecker G, Festjens N, Gabriels S, Parthoens E, D’Herde K, Vandenabeele P (2006) Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells. Cell Death Differ 13:2011–2022
Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR, Newmeyer DD (2002) Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111:331–342
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD (2005) BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17:525–535
Leist M, Jaattela M (2001) Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2:589–598
Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P (1997) Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 185:1481–1486
Leist M, Single B, Naumann H, Fava E, Simon B, Kuhnle S, Nicotera P (1999) Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. Exp Cell Res 249:396–403
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183–192
Li L, Han W, Gu Y, Qiu S, Lu Q, Jin J, Luo J, Hu X (2007) Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res 67:4894–4903
Lindsten T et al (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6:1389–1399
Lindsten T, Golden JA, Zong WX, Minarcik J, Harris MH, Thompson CB (2003) The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci 23:11112–11119
Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431–1568
Liu X, Schnellmann RG (2003) Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death. J Pharmacol Exp Ther 304:63–70
Liu T, Brouha B, Grossman D (2004) Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene 23:39–48
Loeffler M et al (2001) Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J 15:758–767
Lorenzo HK, Susin SA (2004) Mitochondrial effectors in caspase-independent cell death. FEBS Lett 557:14–20
Lorenzo HK, Susin SA (2007) Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist Update 10:235–255
Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S, Shoshan MC (2002) Calpain-mediated Bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol 22:3003–3013
Martinou I, Desagher S, Eskes R, Antonsson B, Andre E, Fakan S, Martinou JC (1999) The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event. J Cell Biol 144:883–889
Mate MJ et al (2002) The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol 9:442–446
Meli E, Pangallo M, Picca R, Baronti R, Moroni F, Pellegrini-Giampietro DE (2004) Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci 25:172–180
Meli E, Baronti R, Pangallo M, Picca R, Moroni F, Pellegrini-Giampietro DE (2005) Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. Neuropharmacology 49(Suppl 1):80–88
Meurette O, Rebillard A, Huc L, Le Moigne G, Merino D, Micheau O, Lagadic-Gossmann D, Dimanche-Boitrel MT (2007) TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. Cancer Res 67:218–226
Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson EM Jr (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139:205–217
Miramar MD et al (2001) NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem 276:16391–16398
Moroni F (2008) Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. Curr Opin Pharmacol 8:96–103
Moroni F et al (2001) Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. Cell Death Differ 8:921–932
Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA (2007) Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27:4844–4862
Munoz-Pinedo C, Guio-Carrion A, Goldstein JC, Fitzgerald P, Newmeyer DD, Green DR (2006) Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci USA 103:11573–11578
Murahashi H et al (2003) Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat. J Leukoc Biol 73:399–406
Nakagawa T et al (2005) Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434:652–658
Nath R et al (1996) Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J 319(Pt 3):683–690
Nelson WG (2004) Prostate cancer prevention. J Nutr 134:3211S–3212S
Nicotera P, Leist M, Manzo L (1999a) Neuronal cell death: A demise with different shapes. Trends Pharmacol Sci 20:46–51
Nicotera P, Leist M, Ferrando-May E (1999b) Apoptosis and necrosis: Different execution of the same death. Biochem Soc Symp 66:69–73
Niimura M et al (2006) Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia. J Cereb Blood Flow Metab 26:1354–1365
Niquet J, Seo DW, Wasterlain CG (2006) Mitochondrial pathways of neuronal necrosis. Biochem Soc Trans 34:1347–1351
Nishimura Y, Lemasters JJ (2001) Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. Cell Death Differ 8:850–858
Nixon RA (2006) Autophagy in neurodegenerative disease: Friend, foe or turncoat? Trends Neurosci 29:528–535
Ohgoh M, Shimizu H, Ogura H, Nishizawa Y (2000) Astroglial trophic support and neuronal cell death: Influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons. J Neurochem 75:925–933
Okada H, Mak TW (2004) Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 4:592–603
Oo TF, Blazeski R, Harrison SM, Henchcliffe C, Mason CA, Roffler-Tarlov SK, Burke RE (1996) Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic. J Neurosci 16:6134–6145
Oppenheim RW, Flavell RA, Vinsant S, Prevette D, Kuan CY, Rakic P (2001) Programmed cell death of developing mammalian neurons after genetic deletion of caspases. J Neurosci 21:4752–4760
Orrenius S, Zhivotovsky B (2006) The future of toxicology – does it matter how cells die? Chem Res Toxicol 19:729–733
Otera H, Ohsakaya S, Nagaura Z, Ishihara N, Mihara K (2005) Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J 24:1375–1386
Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL (1998) The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 273:7770–7775
Perrelet D et al (2000) IAP family proteins delay motoneuron cell death in vivo. Eur J Neurosci 12:2059–2067
Plesnila N, Zhu C, Culmsee C, Groger M, Moskowitz MA, Blomgren K (2004) Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J Cereb Blood Flow Metab 24:458–466
Polster BM, Basanez G, Etxebarria A, Hardwick JM, Nicholls DG (2005) Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem 280:6447–6454
Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, del Rio G, Bredesen DE, Ellerby HM (2002) Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem 277:21836–21842
Saelens X, Festjens N, Parthoens E, Vanoverberghe I, Kalai M, van Kuppeveld F, Vandenabeele P (2005) Protein synthesis persists during necrotic cell death. J Cell Biol 168:545–551
Saez ME, Ramirez-Lorca R, Moron FJ, Ruiz A (2006) The therapeutic potential of the calpain family: New aspects. Drug Discov Today 11:917–923
Saito A et al (2005) Oxidative stress and neuronal death/survival signaling in cerebral ischemia. Mol Neurobiol 31:105–116
Sattler R, Tymianski M (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 24:107–129
Schinzel AC et al (2005) Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci USA 102:12005–12010
Schreiber V, Dantzer F, Ame JC, de Murcia G (2006) Poly(ADP-ribose): Novel functions for an old molecule. Nat Rev Mol Cell Biol 7:517–528
Schweichel JU, Merker HJ (1973) The morphology of various types of cell death in prenatal tissues. Teratology 7:253–266
Scorrano L, Korsmeyer SJ (2003) Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 304:437–444
Seye CI, Knaapen MW, Daret D, Desgranges C, Herman AG, Kockx MM, Bult H (2004) 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. Cardiovasc Res 64:144–153
Shall S, de Murcia G (2000) Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model? Mutat Res 460:1–15
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6:1221–1228
Skaper SD (2003) Poly(ADP-Ribose) polymerase-1 in acute neuronal death and inflammation: A strategy for neuroprotection. Ann N Y Acad Sci 993:217–228; discussion 287–288
Sorimachi H, Suzuki K (2001) The structure of calpain. J Biochem (Tokyo) 129:653–664
Sperandio S, de Belle I, Bredesen DE (2000) An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci USA 97:14376–14381
Srivastava S et al (2007) Apoptosis-inducing factor regulates death in peripheral T cells. J Immunol 179:797–803
Stadelmann C, Bruck W, Bancher C, Jellinger K, Lassmann H (1998) Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol 57:456–464
Stadtman ER, Oliver CN (1991) Metal-catalyzed oxidation of proteins. Physiological consequences. J Biol Chem 266:2005–2008
Stoica BA, Movsesyan VA, Knoblach SM, Faden AI (2005) Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci 29:355–371
Strasser A et al (2000) The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann N Y Acad Sci 917:541–548
Strosznajder R, Gajkowska B (2006) Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. The immunocytochemical study. Acta Neurobiol Exp (Wars) 66:15–22
Susin SA et al (1996) Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184:1331–1341
Susin SA et al (1997) The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med 186:25–37
Susin SA et al (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441–446
Susin SA et al (2000) Two distinct pathways leading to nuclear apoptosis. J Exp Med 192:571–580
Tan Y, Dourdin N, Wu C, De Veyra T, Elce JS, Greer PA (2006) Conditional disruption of ubiquitous calpains in the mouse. Genesis 44:297–303
Thornberry NA, Lazebnik Y (1998) Caspases: Enemies within. Science 281:1312–1316
Toyota H, Yanase N, Yoshimoto T, Moriyama M, Sudo T, Mizuguchi J (2003) Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer Lett 189:221–230
Tsujimoto Y (2002) Bcl-2 family of proteins: life-or-death switch in mitochondria. Biosci Rep 22:47–58
Unal-Cevik I, Kilinc M, Can A, Gursoy-Ozdemir Y, Dalkara T (2004) Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 35:2189–2194
Vahsen N et al (2004) AIF deficiency compromises oxidative phosphorylation. EMBO J 23:4679–4689
van Wijk SJ, Hageman GJ (2005) Poly(ADP-ribose) polymerase-1 mediated caspase-independent cell death after ischemia/reperfusion. Free Radic Biol Med 39:81–90
Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH (2000) BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 20:5454–5468
Vanden Berghe T, van Loo G, Saelens X, Van Gurp M, Brouckaert G, Kalai M, Declercq W, Vandenabeele P (2004) Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J Biol Chem 279:7925–7933
Wang X, Yang C, Chai J, Shi Y, Xue D (2002) Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 298:1587–1592
Wang HM, Shimoji M, Yu SW, Dawson TM, Dawson VL (2003) Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson’s disease. In: Federoff H (eds) Parkinson’s disease: The life cycle of the dopamine neuron. New York Acad Sciences, New York, pp 132–139
Wang H et al (2004) Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 24:10963–10973
Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, Qin ZH (2008) An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-d-aspartate receptor agonist kainic acid. Autophagy 4:214–226
Waring P (2005) Redox active calcium ion channels and cell death. Arch Biochem Biophys 434:33–42
Wei MC et al (2001) Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292:727–730
Whiteman M et al (2007) The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways. Cell Signal 19:705–714
Willis SN, Adams JM (2005) Life in the balance: How BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17:617–625
Willis SN et al (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315:856–859
Wood DE, Thomas A, Devi LA, Berman Y, Beavis RC, Reed JC, Newcomb EW (1998) Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene 17:1069–1078
Wright KM, Linhoff MW, Potts PR, Deshmukh M (2004) Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. J Cell Biol 167:303–313
Xiong ZG et al (2004) Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels. Cell 118:687–698
Ye H et al (2002) DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol 9:680–684
Youle RJ, Strasser A (2008) The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9:47–59
Yu SW et al (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297:259–263
Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103:18314–18319
Yuste VJ et al (2005a) The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA. J Biol Chem 280:35670–35683
Yuste VJ, Moubarak RS, Delettre C, Bras M, Sancho P, Robert N, d’Alayer J, Susin SA (2005b) Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release. Cell Death Differ 12:1445–1448
Zhang X et al (2002) Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 82:181–191
Zhu C, Qiu L, Wang X, Hallin U, Cande C, Kroemer G, Hagberg H, Blomgren K (2003) Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain. J Neurochem 86:306–317
Zhu C, Wang X, Qiu L, Peeters-Scholte C, Hagberg H, Blomgren K (2004) Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia. J Neurochem 90:462–471
Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y, Blomgren K, Hagberg H (2006) Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem 96:1016–1027
Zhu C et al (2007) Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ 14:775–784
Zolotarjova N, Ho C, Mellgren RL, Askari A, Huang WH (1994) Different sensitivities of native and oxidized forms of Na+/K(+)-ATPase to intracellular proteinases. Biochim Biophys Acta 1192:125–131
Zong WX, Thompson CB (2006) Necrotic death as a cell fate. Genes Dev 20:1–15
Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18:1272–1282
Acknowledgments
We apologize to colleagues whose original work we could not cite owing to limitations of space. The authors wish to thank Marcela Segade for invaluable help. Our research is supported by institutional grants from Institut Pasteur and CNRS and by specific grants from Ligue Contre le Cancer and Association pour la Recherche sur le Cancer (ARC; contract n° 4043) to Santos A. Susin and joint INSERM/FRSQ cooperation programme to Slavica Krantic (France) and Remi Quirion (Canada).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Krantic, S., Susin, S.A. (2010). Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons?. In: Fujikawa, D. (eds) Acute Neuronal Injury. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73226-8_3
Download citation
DOI: https://doi.org/10.1007/978-0-387-73226-8_3
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-73225-1
Online ISBN: 978-0-387-73226-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)