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New Tools for Assessing Breast Cancer Recurrence

  • Phuong Dinh
  • Fatima Cardoso
  • Christos Sotiriou
  • Martine J. Piccart-Gebhart
Part of the Cancer Treatment and Research book series (CTAR, volume 141)

Breast cancer is the most common cancer in women in the Western world, and is essentially incurable when distant metastases are detected. Despite an increasing incidence, breast cancer mortality has fallen, largely due to the advent of widespread screening programs, but also partly due to the increasing use of adjuvant systemic treatment and advances in loco-regional control.

This chapter will review the advances in gene expression profiling, made possible with microarray technology, as new tools for assessing breast cancer recurrence. It will discuss the molecular classification of breast cancer subtypes, as well as the various molecular signatures with their prognostic and predictive implications. Two prospective randomized trials, MINDACT and TAILORx, designed to validate this new technology, will be briefly discussed.

Keywords

Breast Cancer Estrogen Receptor National Comprehensive Cancer Network National Comprehensive Cancer Network Gene Expression Signature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Phuong Dinh
    • 1
  • Fatima Cardoso
    • 1
  • Christos Sotiriou
    • 1
  • Martine J. Piccart-Gebhart
    • 1
  1. 1.Department of Medical OncologyUniversite Libre de BruxellesBelgium

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