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Oxidative Damage and Repair in the Mitochondrial Genome

  • Chapter
Oxidative Damage to Nucleic Acids

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

DNA is constantly exposed to damaging agents from both endogenous and exogenous sources. If this damage is not repaired, it can lead to mutations and result in cellular dysfunction, including uncontrolled cell proliferation. Thus, in order to maintain the integrity of the genome, a complex network of DNA repair pathways exists to remove the majority of deleterious lesions. However, DNA repair may occasionally fail or become limited due to an excess DNA damage, resulting in DNA damage accumulation.

Characterization of DNA repair mechanisms has generally focused on these processes in nuclear DNA. While the interest and research efforts concerning DNA repair in mitochondria have increased, much is still to be learned. In this chapter, we will focus on current knowledge of oxidative DNA damage and repair systems in the mitochondrion, make comparisons to what is known about repair in nucleus, as well as discuss the link between dysfunctional mitochondria and human disease.

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Authors and Affiliations

  1. Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, 14263, USA

    Keshav K. Singh

  2. Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark

    Lene Juel Rasmussen

Authors
  1. Lene Juel Rasmussen
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  2. Keshav K. Singh
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Editors and Affiliations

  1. Radiation and Oxidative Stress Group Department of Cancer Studies and Molecular Medicine RKCSB, Leicester Royal Infirmary, University of Leicester, Leicester, UK

    Mark D. Evans B.Sc., Ph.D.

  2. Department of Cancer Studies and Molecular Medicine and Department of Genetics, University of Leicester, Leicester, UK

    Marcus S. Cooke B.Sc., M.Sc., Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Rasmussen, L.J., Singh, K.K. (2007). Oxidative Damage and Repair in the Mitochondrial Genome. In: Evans, M.D., Cooke, M.S. (eds) Oxidative Damage to Nucleic Acids. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72974-9_9

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