OGG1: From Structural Analysis to the Knockout Mouse

  • Arne Klungland
  • Jon K. Laerdahl
  • Torbjørn Rognes
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Among the four DNA bases, guanine, having the lowest redox potential, is the most susceptible to oxidation, and among the oxidized bases 7,8-dihydro-8-oxoguanine (8-oxoG) is certainly the lesion that has retained most attention over many years. This altered base can pair with A as well as C residues during replication. Eukaryotic cells use a specific DNA glycosylase, 8-oxoG DNA glycosylase (OGG1), to excise 8-oxoG from DNA, and repair-deficient cells are characterized by an increased G to T transversion frequency. It is essential that OGG1 has the ability to distinguish between 8-oxoG:C and 8-oxoG:A pairs and only removes 8-oxoG paired with C. This review will discuss the structural basis for OGG1 damage recognition and specificity as well as the literature on the biological consequences of OGG1 deficiency.


Base Excision Repair Cockayne Syndrome Glycosylase Activity OGG1 Ser326Cys Spontaneous Mutation Frequency 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Arne Klungland
    • 1
  • Jon K. Laerdahl
    • 1
  • Torbjørn Rognes
    • 1
  1. 1.Centre for Molecular Biology and Neuroscience and Institute of Medical MicrobiologyRikshospitalet-RadiumhospitaletOsloNorway

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