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Oxidatively Damaged DNA and Inflammation

  • Peter C. Dedon
  • Marita C. Barth
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Chronic inflammation has long been associated with diseases such as cancer and cardiovascular disease, with infectious processes playing a causal role in many types of cancer. One potential link between chronic inflammation and human disease involves the release of highly reactive oxygen and nitrogen species by macrophages and neutrophils in inflamed tissues. In addition to their intended targets, these species also attack surrounding host tissue cells, with damage to virtually all cellular components, including DNA, RNA, proteins, carbohydrates and lipids. This chapter addresses the role of inflammatory processes in DNA damage in cells and tissues, whether by direct attack on DNA or by indirect mechanisms involving generation of electrophiles that subsequently react with DNA to form adducts.

Keywords

Nitric Oxide Nitric Oxide Chemical Mediator Abasic Site Guanine Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Peter C. Dedon
    • 1
  • Marita C. Barth
    • 1
  1. 1.Center for Environmental Health Sciences and Biological Engineering DivisionMassachusetts Institute of Technology, NE47-277CambridgeUSA

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