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Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases

  • Maria Grazia Andreassi
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Cardiovascular disease is the dominant health problem in the western world. The most frequent underlying cause of cardiovascular disease is atherosclerosis. The cellular and molecular mechanisms involved in atherosclerosis and its acute complications are being defined, but much is still unknown. Growing evidence indicates that oxidative damage to nuclear and mitochondrial DNA may represent an important link between the inflammatory nature and the oxidative theory of atherosclerosis. Various animal models of atherosclerosis support the evidence that oxidatively damaged DNA plays a key role in both the formation and the complications of atherosclerosis. Human investigations also support a mutational hypothesis of atherosclerosis. Future research on the mechanism by which oxidatively damaged DNA participates in the atherogenic process may provide new insights for early diagnosis and treatment of atherosclerosis.

Keywords

Atherosclerotic Plaque Atherosclerotic Lesion Microsatellite Instability Human Atherosclerotic Plaque Atherogenic Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Maria Grazia Andreassi
    • 1
  1. 1.CNR Institute of Clinical PhysiologyG. Pasquinucci HospitalMassaItaly

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