Properties And Evolution Of Allosteric Enzymes

The purpose of regulatory enzymes is to permit control of the rate at a specific metabolic step. There are two major groups of allosteric enzymes. Both employ a change in affinity for the substrate to alter activity. One of the groups experiences only a change in affinity for the principal substrate, while keeping the maximum rate fairly constant (K-type enzymes). The second group also demonstrates significant changes in affinity for the main substrate, and in addition has large changes in the maximum rate (V-type enzymes). The greatest changes in Vmax are for enzymes that act as regulatory switches.


Regulatory Subunit Covalent Modification Glycogen Phosphorylase Allosteric Site Inactive Conformation 
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© Springer Science+Business Media, LLC 2008

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