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Properties And Evolution Of Allosteric Enzymes

The purpose of regulatory enzymes is to permit control of the rate at a specific metabolic step. There are two major groups of allosteric enzymes. Both employ a change in affinity for the substrate to alter activity. One of the groups experiences only a change in affinity for the principal substrate, while keeping the maximum rate fairly constant (K-type enzymes). The second group also demonstrates significant changes in affinity for the main substrate, and in addition has large changes in the maximum rate (V-type enzymes). The greatest changes in Vmax are for enzymes that act as regulatory switches.

Keywords

Regulatory Subunit Covalent Modification Glycogen Phosphorylase Allosteric Site Inactive Conformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

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