Introduction To V-Type Enzymes

V-type enzymes are named for their often remarkable changes in Vmax when they are allosterically activated. However, these enzymes also generally have a comparable change in their affinity for the substrate. When such enzymes are in a normal metabolic pathway, changes in the maximum activity can be up to 30-fold. To be included in this category, enzymes must have at least a doubling in Vmax, so that this allosteric effect can be physiologically or experimentally meaningful. When these enzyme activities are part of a regulatory switch, the change in activity may exceed 100,000-fold.


Pyruvate Carboxylase Regulatory Switch Saturate Substrate Allosteric Effect Phosphoglycerate Dehydrogenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media, LLC 2008

Personalised recommendations