Anatomical Changes in the Aging Kidney

  • Xin J. Zhou
  • Zoltan G. Laszik
  • Fred G. Silva


Mean Arterial Blood Pressure Glomerular Basement Membrane Tubular Atrophy Afferent Arteriole Nephron Number 
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  1. Silva, F.G. The aging kidney: A review—Part I. Int. Urol. Nephrol. 2005; 37:185–205.PubMedCrossRefGoogle Scholar
  2. Silva, F.G. The aging kidney: A review—Part II. Int. Urol. Nephrol. 2005; 37:419–432.PubMedCrossRefGoogle Scholar
  3. McLachlan, M. Anatomic structural and vascular changes in the aging kidney. In Cameron, J.S., Macias Núñez, J.F., eds. Renal Function and Disease in Elderly. Butterworth-Heinemann, New York 1987; pp. 3–26.Google Scholar
  4. Tauchi, H., Tsuboi, K., Okutomi, J. Age changes in the human kidney of different races. Gerontologia 1971; 17:87–97.PubMedCrossRefGoogle Scholar
  5. Bax, L., van der Fraaf, Y., Rabelink, A.J., Algra, A., Beutler, J.J., Mali, W.P.; SMART Study Group. Influence of atherosclerosis on age-related changes in renal size and function. Eur. J. Clin. Invest 2003; 22:34–40.Google Scholar
  6. Kasiske, B.L., Umen, A.J. The influence of age, sex, race and body habits on kidney weight in humans. Arch. Path. 1986; 110:44–60.Google Scholar
  7. Tada, S., Yamagishi, J., Kobayashi, H., Hata, Y., Kobari, T. The incidence of simple renal cysts by computed tomography. Clin. Radiol. 1983; 34:437–439.PubMedCrossRefGoogle Scholar
  8. Baert, L., Steg, A. Is the diverticulum of the distal and collecting tubules a preliminary stage of the simple cyst in the adult? J. Urol. 1977; 118:707–710.PubMedGoogle Scholar
  9. Steffes, M.W., Barbosa, J., Basgen, J.M., Sutherland, D.E.R., Najarian, S.J., Mauer, S.M. Quantitative glomerular morphology of the normal human kidney. Lab. Invest. 1983; 49:82–86.PubMedGoogle Scholar
  10. Kasiske, B.L. Relationship between vascular disease and age-associated changes in the human kidney. Kidney Int. 1987; 1154–1159.Google Scholar
  11. Neugarten, J., Gallo, G., Sibiger, S., Kasiske, B. Glomerulosclerosis in aging humans is not influenced by gender. Am. J. Kid. Dis. 1999; 34:884–888.PubMedGoogle Scholar
  12. Li, M., Nicholls, K.M., Becker, G.J. Glomerular size and global glomerulosclerosis in normal Caucasian donor kidneys: Effects of aging and gender. J. Nephrol. 2002; 15:614–619.PubMedGoogle Scholar
  13. Takazakura, E., Sawabu, N., Handa, A., Takada, A., Shinoda, A., Takeuchi, J. Intrarenal vascular changes with age and disease. Kidney Int. 1972; 2:224–230.PubMedCrossRefGoogle Scholar
  14. Newbold, K.M., Sandison, A., Howie, A.J. Comparison of size of juxtamedullary and outer cortical glomeruli in normal adult kidney. Virchows Arch. A Path. Anat. Histopathol. 1992; 420:127–129.CrossRefGoogle Scholar
  15. Nyengaard, J.R., Bendtsen, T.F. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat. Rec. 1992; 232:194–201.PubMedCrossRefGoogle Scholar
  16. Hughson, M., Farris, A.B. III, Douglas-Denton, R., Hoy, W.E., Bertram, J.F. Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int. 2003; 63:2113–2122.PubMedCrossRefGoogle Scholar
  17. Hughson, M.D., Douglas-Denton, R., Bertram, J.F., Hoy, W.E. Hypertension, glomerular number, and birth weigh in African Americans and Whites subjects in the Southeastern United States. Kidney Int. 2006; 69:671–678.PubMedCrossRefGoogle Scholar
  18. Keller, G., Zimmer, G., Mall, G., Ritz, E., Amann, K. Nephron number in patients with primary hypertension. N. Engl. J. Med. 2003; 348:101–108.PubMedCrossRefGoogle Scholar
  19. Samuel, T., Hoy, W.E., Douglas-Denton, R., Hughson, M.D., Bertram, J.F. Determinants of glomerular volume in different cortical zones of the human kidney. J. Am. Soc. Nephrol. 2005; 16:3102–3109.PubMedCrossRefGoogle Scholar
  20. Meadows, R. Renal Histopathology, 2nd ed. Oxford: Oxford University Press. 1978; Chapter 9: The Obsolescent Glomerulus and the Disappearance of Glomeruli from Kidneys, pp. 154–163.Google Scholar
  21. Verani, R., Silva, F., Hogg, R., and the Southwest Pediatric Nephrology Study Group. A clinico-pathologic study of crescentic glomerulonephritis in 50 children. Kidney Int. 1985; 27:450–458.CrossRefGoogle Scholar
  22. Remuzzi, A., Mazerska, M., Gephardt, G.N., Novick, A.C., Brenner, B.M., Remuzzi, G. Three-dimensional analysis of glomerular morphology in patients with subtotal nephrectomy. Kidney Int. 1995; 48:155–162.PubMedCrossRefGoogle Scholar
  23. Kaplan, C., Pasternack, B., Shah, H., Gallo, G. Age-related incidence of sclerotic glomeruli in human kidneys. Am. J. Path. 1995; 80:227–234.Google Scholar
  24. Smith, S.M., Hoy, W.E., Cobb, L. Low incidence of glomerulosclerosis in normal kidneys. Arch. Path. Lab. Med. 1989; 118:1253–1255.Google Scholar
  25. Taal, M.W., Luycks, V.A., Brenner, B.M. Adaptation to nephron loss. In Brenner and Rector’s, The Kidney, 7th ed., Brenner, B.M., ed. Philadelphia, Saunders. 2004; pp. 1955–1997.Google Scholar
  26. Brenner, B.M. Nephrology forum: Hemodynamically mediated glomerular injury and the progressive nature of renal disease. Kidney Int. 1983; 23:647–655.PubMedCrossRefGoogle Scholar
  27. Newbold, K.M., Sandison, A., Howie, A.J. Comparison of size of juxtamedullary and outer cortical glomeruli in normal adult kidney. Virchows Arch. A Path. Anat. Histopath. 1992; 420:127–129.CrossRefGoogle Scholar
  28. Piranci, C.L., Silva, F.G. The glomerulus: Current concepts. In Hemostasis, Prostaglandins and Renal Disease, Remuzzi, G., Mecca, G., and de Gaetano, G., eds., New York: Raven Press. 1980; pp. 25–44.Google Scholar
  29. Lindeman, R.D., Goldman, R. Anatomic and physiologic age changes in the kidney. Exp. Geront. 1986; 21:379–406.CrossRefGoogle Scholar
  30. Nath, K.A. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am. J. Kidney Dis. 1992; 20:1.PubMedGoogle Scholar
  31. Eknoyan, G., McDonald, M.A., Appel, D., Truong, J.D. Chronic tubulo-interstitial nephritis: Correlation between structural and functional findings. Kidney Int. 1990; 38:736–743.PubMedCrossRefGoogle Scholar
  32. Nadasdy, T., Laszik, Z., Blick, K., Johnson, D.L., Silva, F.G. Tubular atrophy in the end-stage kidney: A lectin and immunohistochemical study. Human Path. 1994; 25:22–28.CrossRefGoogle Scholar
  33. Meguid, E.L., Nahas, E. Plasticity of kidney cells: Role in kidney remodeling and scarring. Kidney Int. 2003; 64:1553–1563.CrossRefGoogle Scholar
  34. Greenfeld, Z., Baylis, C. Aging and the renal circulation. In Advances in Organ Biology Stamford, CT: JAI Press. 2000; 9:255–274.Google Scholar
  35. Tracy, R.E., Malcom, G.T., Oalmann, M.C., Qureshi, U., Ishii, T., Velez-Duran, M. Renal microvascular features of hypertension in Japan, Guatemala and the Unites States. Arch. Path. Lab. Med. 1992; 116:50–55.PubMedGoogle Scholar
  36. Tracy, R.E., Parra, D., Eisaguirre, W., Balanza, R.A.T. Influence of arteriolar hyalinization on arterial intimal fibroplasias in the renal cortex of subjects in the United States, Peru and Bolivia, applicable also to other populations. Am. J. Hypertension 2002; 15:1064–1073.CrossRefGoogle Scholar
  37. Tracy, R.E., Ishii, T. What is “nephrosclerosis?” Lessons from the US, Japan and Mexico. Nephrol. Dial. Transplant. 2002; 15:1337–1366.Google Scholar
  38. Tracy, R.E., Newmann, W.P. III, Wattigney, W.A., Srinivasan, S.R., Strong, J.P., Berenson, G.S. Histologic features of atherosclerosis and hypertension from autopsies of young individuals in a defined geographic population: The Bogalusa heart study. Atherosclerosis 1995; 116:163–179.PubMedCrossRefGoogle Scholar
  39. Tracy, R.E., Overall, E.O. Arterioles of perfusion-fixed hypertensive and aged kidneys. Arch. Path. 1966; 82:526–534.PubMedGoogle Scholar
  40. Tracy, R.E. Histologic characteristics of coronary artery in relation to the renovasculopathies of hypertension. Ann. Diagnostic Path. 1998; 2:159–166.CrossRefGoogle Scholar
  41. Hill, G.S., Hedes, D., Bariety, J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int. 2003; 63:1027–1036.PubMedCrossRefGoogle Scholar
  42. Volhard, F., Fahr, T. Die Brightische Nierenkrankheit. Berlin: Springer-Verlag, 1914.Google Scholar
  43. Fogo, A., Breyer, J.A., Smith, M.C., Cleveland, W.H., Agodoa, L., Kirk, K.A., Glassock, R. Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: A report from the African American study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. Kidney Int. 1997; 51:244–252.PubMedCrossRefGoogle Scholar
  44. Frocht, A., Fillit, H. Renal disease in the geriatric patient. J. Am. Geriatr. Soc. 1984; 32:28–43.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Xin J. Zhou
  • Zoltan G. Laszik
  • Fred G. Silva

There are no affiliations available

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