Advertisement

Substitutive Treatments of End-Stage Renal Diseases in the Elderly: Renal Transplantation

  • Ali Alobaidli
  • Sarbjit V. Jassal

Keywords

Renal Transplantation Renal Replacement Therapy Dialysis Patient Graft Survival Renal Transplant Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Canadian Organ Replacement Register (CORR). Annual Report 2001.Google Scholar
  2. 2.
    U.S. Renal Data System. USRDS Annual Data Report 2005.Google Scholar
  3. 3.
    Agodoa, L.Y., Eggers, P.W. Renal replacement therapy in the United States: Data from the USRDS. Am. J. Kidney Dis. 1995; 25:119–133.PubMedGoogle Scholar
  4. 4.
    Fenton, S., Desmeules, M., Copleston, P., Arbus, G., Froment, D., Jeffery, J., Kjellstrand, C. Renal replacement therapy in Canada: A report from the Canadian Organ Replacement Register. Am. J. Kidney Dis.1995; 25:134–150.PubMedGoogle Scholar
  5. 5.
    Disney, A.P. Demography and survival of patients receiving treatment for chronic renal failure in Australia and New Zealand: Report on dialysis and renal transplantation treatment from the Australia and New Zealand Dialysis and Transplant Registry. Am. J. Kidney Dis. 1995; 25(1):165–175.PubMedGoogle Scholar
  6. 6.
    Disney, A.P.S., Russ, G.R., Walker, R., Sheil, A.G.R. Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) Report. 1997.Google Scholar
  7. 7.
    The U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients OPTN/SRTR Annual Report. 2001.Google Scholar
  8. 8.
    Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) Annual Report. 2001.Google Scholar
  9. 9.
    http://secure.cihi.ca/cihiweb. CORR inSITES, April 2003. A Decade of Organ Donation in Canada: 1993 to 2002: Figure 7: Distribution of kidney transplants by donor type, Canada 1993–2002.Google Scholar
  10. 10.
    Ghods, A.J. Renal transplantation in Iran. Nephrol. Dial. Transplant 2002; 17(2):222–228.PubMedCrossRefGoogle Scholar
  11. 11.
    Ghods, A.J. Changing ethics in renal transplantation: Presentation of Iran model. Transplant. Proc. 2004; 36(1):11–13.PubMedCrossRefGoogle Scholar
  12. 12.
    Port, F.K., Wolfe, R.A., Mauger, E.A., Berling, D.P., Jiang, K. Comparison of survival probabilities for dialysis patients vs. cadaveric renal transplant recipients. JAMA 1993; 270(11):1339–1343.PubMedCrossRefGoogle Scholar
  13. 13.
    Rabbat, C.G., Thorpe, K.E., Russell, J.D., Churchill, D.N. Comparison of mortality risk for dialysis patients and cadaveric first renal transplant recipients in Ontario, Canada. J. Am. Soc. Nephrol. 2000; 11(5):917–922.PubMedGoogle Scholar
  14. 14.
    Wolfe, R.A., Ashby, V.B., Milford, E.L., Ojo, A.O., Ettenger, R.E., Agodoa, L.Y., Held, P.J., Port, F.K. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N. Engl. J. Med. 1999; 341(23):1725–1730.PubMedCrossRefGoogle Scholar
  15. 15.
    USRDS Annual Data Report 2003. Reference tables. http://www.usrds.org/2003/pdf/g_03.pdf.Google Scholar
  16. 16.
    Andreu, J., de la Torre, M., Oppenheimer, F., Campistol, J.M., Ricart, M.J., Vilardell, J., et al. Renal transplantation in elderly recipients. Transplant. Proc. 1992; 24(1):120–121.PubMedGoogle Scholar
  17. 17.
    DeLuca, L., Cardella, C.J. How can the care of elderly dialysis patients be improved? Sem. Dial. 1992; 5:28–29.CrossRefGoogle Scholar
  18. 18.
    Sanches-Fructuso, A.I., Naranjo, D.P., Fernandez, C., Aviles, B., Barrientos, A. Renal transplantation in elderly patients. Transplant. Proc. 1998; 30:2277.CrossRefGoogle Scholar
  19. 19.
    Basar, H., Soran, A., Shapiro, R., Vivas, C., Scantlebury, V.P., Jordan, M.L., Gritsch, H.A., McCauley, J., Randhawa, P., Irish, W., Hakala, T.R., Fung, J.J. Renal transplantation in recipients over the age of 60: The impact of donor age. Transplantation 1999; 67(8):1191–1193.PubMedCrossRefGoogle Scholar
  20. 20.
    Doyle, S.E., Matas, A.J., Gillingham, K., Rosenberg, M.E. Predicting clinical outcome in the elderly renal transplant recipient. Kidney Int. 2000; 57:2144.PubMedCrossRefGoogle Scholar
  21. 21.
    Fabrizii, V., Winkelmayer, W.C., Klauser, R., Kletzmayr, J., Saemann, M.D., Steininger, R., Kramar, R., Horl, W.H., Kovarik, J. Patient and graft survival in older kidney transplant recipients: Does age matter? J. Am. Soc. Nephrol. 2004; 15(4):1052–1060.PubMedCrossRefGoogle Scholar
  22. 22.
    Moreso, F., Ortega, F., Mendiluce, A. Recipient age as a determinant factor of patient and graft survival. Nephrol. Dial. Transplant 2004; 19(Suppl 3):16–20.Google Scholar
  23. 23.
    Roodnat, J.I., Zietse, R., Mulder, P.G., Rischen-Vos, J., van Gelder, T., Ijzermans, J.N., Weimar, W. The vanishing importance of age in renal transplantation. Transplantation 1999; 67(4):576–580.PubMedCrossRefGoogle Scholar
  24. 24.
    Herrero, J.C., Gutierrez, E., Martinez, A., Gonzalez, E., Morales, E., Munoz, M.A., Valentin, M., Bueno, B., Praga, M., Hernandez, E., Morales, J.M., Rodicio, J.L., Andres, A. Results of kidney transplantation in recipients over 70 years of age: Experience at a single center. Transplant. Proc. 2003; 35(5):1675–1676.PubMedCrossRefGoogle Scholar
  25. 25.
    Saudan, P., Berney, T., Leski, M., Morel, P., Bolle, J.F., Martin, P.Y. Renal transplantation in the elderly: A long-term, single-centre experience. Nephrol. Dial. Transplant 2001; 16(4):824–828.PubMedCrossRefGoogle Scholar
  26. 26.
    Moosa, M.R. Impact of age, gender and race on patient and graft survival following renal transplantation—Developing country experience. S. Afr. Med. J. 2003; 93(9):689–695.PubMedGoogle Scholar
  27. 27.
    Meier-Kriesche, H.U., Ojo, A.O., Hanson, J.A., Kaplan, B. Exponentially increased risk of infectious death in older renal transplant recipients. Kidney Int. 2001; 59(4):1539–1543.PubMedCrossRefGoogle Scholar
  28. 28.
    Morales, J.M., Munoz, M.A., Campo, C., Andres, A., Araque, A., Alamo, C., Praga, M., Ortuno, T., Hernandez, E., Rodicio, J.L. Renal transplantation in older patients with double therapy with optional change to cyclosporine monotherapy: Long-term results. Transplant. Proc. 1994; 26(5):2511–2512.PubMedGoogle Scholar
  29. 29.
    Andreu, J., de la Torre, M., Oppenheimer, F., Campistol, J.M., Ricart, M.J., Vilardell, J., Talbot, R., Carretero, P. Renal transplantation in elderly recipients. Transplant. Proc. 1992; 24(1):120–121.PubMedGoogle Scholar
  30. 30.
    Spanish Monotherapy Study Group. Cyclosporine monotherapy versus OKT3 and cyclosporine versus prednisone and cyclosporine as induction therapy in older renal transplant patients: A multicenter randomized study. Transplant. Proc. 1994; 26(5):2522–2524.Google Scholar
  31. 31.
    Xenos, E.X., Ciancio, G., Burke, G.W., Roth, D., Miller, J. The use of tacrolimus as induction and maintenance immunosuppression in renal cadaveric transplant recipients over the age of 60. Clin. Transplant. 1997; 11(5 Pt 2):497–499.PubMedGoogle Scholar
  32. 32.
    Hardman, J.G., Limbird, L.E. eds. The Pharmacological Basis of Therapeutics. New York: McGraw Hill & Co. 1996.Google Scholar
  33. 33.
    Meier-Kriesche, H.U., Friedman, G., Jacobs, M., Mulgaonkar, S., Vaghela, M., Kaplan, B. Infectious complications in geriatric renal transplant patients: Comparison of two immunosuppressive protocols. Transplantation 1999; 68(10):1496–1502.PubMedCrossRefGoogle Scholar
  34. 34.
    Johnson, D.W., Nicol, D.L., Purdie, D.M., Preston, J.M., Brown, A.M., Hawley, C.M., Campbell, S.B., Wall, D., Griffin, A.D., Isbel, N.M. Is mycophenolate mofetil less safe than azathioprine in elderly renal transplant recipients? Transplantation 2002; 73(7):1158–1163.PubMedCrossRefGoogle Scholar
  35. 35.
    Lundgren, G., Fehrman, I., Gunnarsson, R., Lindholm, B., Tillegard, A., Ost, L., Groth, C.G. Cadaveric renal transplantation in patients over 55 years of age with special emphasis on immunosuppressive therapy. Transplant. Proc. 1982; 14(3):601–604.PubMedGoogle Scholar
  36. 36.
    Jordan, M.L., Novick, A.C., Steinmuller, D., Braun, W., Buszta, C., Mintz, D., Goormastic, M., Streem, S. Renal transplantation in the older recipient. J. Urol. 1985; 134(2):243–246.PubMedGoogle Scholar
  37. 37.
    Emparan, C., Laukotter, M., Wolters, H., Dame, C., Heidenreich, S., Senninger, N. Calcineurin-free protocols with basiliximab induction allow patients included in “old to old” programs achieve standard kidney transplant function. Transplant. Proc. 2003; 35(4):1326–1327.PubMedCrossRefGoogle Scholar
  38. 38.
    Nyberg, G., et al. Physical performance does not improve in elderly patients following successful kidney transplantation. Nephrol. Dial. Transplant 1995; 10:86–90.PubMedGoogle Scholar
  39. 39.
    Okechukwu, C.N., Lopes, A.A., Stack, A.G., Feng, S., Wolfe, R.A., Port, F.K. Impact of years of dialysis therapy on mortality risk and the characteristics of longer term dialysis survivors. Am. J. Kidney Dis. 2002; 39(3):533–538.PubMedGoogle Scholar
  40. 40.
    Bonal, J., Cleries, M., Vela, E. Transplantation versus haemodialysis in elderly patients. Renal Registry Committee. Nephrol. Dial. Transplant 1997; 12(2): 261–264.PubMedCrossRefGoogle Scholar
  41. 41.
    Jofre, R., Lopez-Gomez, J.M., Moreno, F., Sanz-Guajardo, D., Valderrabano, F. Changes in quality of life after renal transplantation. Am. J. Kidney Dis. 1998; 32(1):93–100.PubMedGoogle Scholar
  42. 42.
    Laupacis, A., Keown, P., Pus, N., Krueger, H., Ferguson, B., Wong, C., Muirhead, N. A study of the quality of life and cost-utility of renal transplantation. Kidney Int. 1996; 50(1):235–242.PubMedCrossRefGoogle Scholar
  43. 43.
    Cameron, J.I., Whiteside, C., Katz, J., Devins, G.M. Differences in quality of life across renal replacement therapies: A meta-analytic comparison. Am. J. Kidney Dis. 2000; 35(4):629–637.PubMedGoogle Scholar
  44. 44.
    Dialysis Outcomes and Practice Patterns Study (DOPPS) 2005. http://www. dopps.org.Google Scholar
  45. 45.
    Steinman, T.I., Becker, B.N., Frost, A.E., Olthoff, K.M., Smart, F.W., Suki, W.N., Wilkinson, A.H.; Clinical Practice Committee, American Society of Transplantation. Guidelines for the referral and management of patients eligible for solid organ transplantation. Transplantation 2001; 71(9):1189–1204.PubMedCrossRefGoogle Scholar
  46. 46.
    Ismail, N. Renal transplantation and the elderly. UpToDate 2004.Google Scholar
  47. 47.
    Kasiske, B.L., Cangro, C.B., Hariharan, S., Hricik, D.E., Kerman, R.H., Roth, D., Rush, D.N., Vazquez, M.A., Weir, M.R.; American Society of Transplantation. The evaluation of renal transplantation candidates: Clinical practice guidelines. Am. J. Transplant 2002; 1(Suppl 2):1–95.Google Scholar
  48. 48.
    Andres, A., Morales, J.M., Herrero, J.C., Praga, M., Morales, E., Hernandez, E., Ortuno, T., Rodicio, J.L., Martinez, M.A., Usera, G., Diaz, R., Polo, G., Aguirre, F., Leiva, O. Double versus single renal allografts from aged donors. Transplantation 2000; 69(10):2060–2066.PubMedCrossRefGoogle Scholar
  49. 49.
    Remuzzi, G., Grinyo, J., Ruggenenti, P., Beatini, M., Cole, E.H., Milford, E.L., Brenner, B.M. Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG). J. Am. Soc. Nephrol. 1999; 10(12):2591–2598.PubMedGoogle Scholar
  50. 50.
    Remuzzi, G., Ruggenenti, P. Renal transplantation: Single or dual for donors aging > or =60 years? Transplantation 2000; 69:2000–2001.PubMedCrossRefGoogle Scholar
  51. 51.
    Ojo, A.O., Hanson, J.A., Meier-Kriesche, H., Okechukwu, C.N., Wolfe, R.A., Leichtman, A.B,, Agodoa, LY., Kaplan, B., Port, F.K. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J. Am. Soc. Nephrol. 2001; 12(3):589–597.PubMedGoogle Scholar
  52. 52.
    Ost, L., Groth, C.-G., Lindholm, B., Lundgren, G., Magnusson, G., Tillegard, A. Cadaveric renal transplantation in patients of 60 years of age and above. Transplantation 1980; 30:339–340.PubMedCrossRefGoogle Scholar
  53. 53.
    Sommer, B.G., Ferguson, R.M., Davin, T.D., Kjellstrand, C.M., Fryd, D.S., Simmons, R.L., et al. Renal transplantation in patients over 50 years of age. Transplant. Proc. 1981; 13:33–35.PubMedGoogle Scholar
  54. 54.
    Lundgren, G., Fehrman, I., Gunnarsson, B., Lindholm, B., Tilligard, A., Ost, L., et al. Cadaveric renal transplantation in patients over 55 years of age with special emphasis on immunosuppressive therapy. Transplant. Proc. 1982; 14:601–604.PubMedGoogle Scholar
  55. 55.
    Jordan, M.L., Novick, A.C., Steinmuller, D., Braun, W., Buszta, C., Mint, Z.D., et al. Renal transplantation in the older recipient. J. Urol. 1985; 134:243–246.PubMedGoogle Scholar
  56. 56.
    Sommer, B.G., Mandelbaum, D.M., Henry, M.L., Ferguson, R.M. Renal transplantation in the middle-aged and elderly uremic patient. In Geriatric Nephrology, D.G. Oreopoulos, ed. Dordecht: Martinus Nijhoff. 1986; pp. 157–168.Google Scholar
  57. 57.
    Pirsch, J.D., Stratta, R.J., Armbrust, M.J., D’Alessandro, A.M., Sollinger, H.W., Kalayoglu, M., et al. Cadaveric renal transplantation with cyclosporine in patients more than 60 years of age. Transplantation 1989; 47:259–261.PubMedCrossRefGoogle Scholar
  58. 58.
    Morris, G.E., Jamieson, N.V., Small, J., Evans, D.B., Calne, S.R. Cadaveric renal transplantation in elderly recipients: Is it worthwhile? Nephrol. Dial. Transplant 1991; 6:887–892.PubMedGoogle Scholar
  59. 59.
    Tesi, R.J., Elkhammas, E.A., Davies, E.A., Henry, M.L., Ferguson, R.M. Renal transplantation in older people. Lancet 1994; 343:461–464.PubMedCrossRefGoogle Scholar
  60. 60.
    Albrechtson, D., Leivestad, T., Sodal, G., Bentdal, O., Berg, K.G., Brekke, I., et al. Kidney transplantation in patients older than 70 years of age. Transplant. Proc. 1995; 27(1):86–88.Google Scholar
  61. 61.
    Baid-Agrawal, S., Reinke, P., Schindler, R., Tullius, S., Frei, U. Congress Report WCN 2003 Satellite Symposium on Kidney Transplantation in the Elderly, Weimar, Germany, June 12–14, 2003. Nephrol. Dial. Transplant 2004; 19:43–46.PubMedCrossRefGoogle Scholar
  62. 62.
    Peddi, V.R., Katznelson, S., Halukurike, V., Baker, T.J., McBride, M.A. State of renal transplantation in older Americans: An analysis of the UNOS database. American Transplant Congress Meeting, May 18, 2004.Google Scholar
  63. 63.
    Jassal, S.V., Krahn, M.D., Naglie, G., Zaltzman, J.S., Roscoe, J.M., Cole, E.H., Redelmeier, D.A. Kidney transplantation in the elderly: A decision analysis. J. Am. Soc. Nephrol. 2003; 14(1):187–196.PubMedCrossRefGoogle Scholar
  64. 64.
    Matas, A.J., Gillingham, K.J., Sutherland, D.E.R. Half-life and risk factors for kidney transplant outcome: Importance of death with function. Transplantation 1993; 55:757–761.PubMedCrossRefGoogle Scholar
  65. 65.
    Oniscu, G., Brown, H., Forsyth, J.L. How old is old for transplantation? Am. J. Transplant. 2004; 4:2067–2074.PubMedCrossRefGoogle Scholar
  66. 66.
    Oniscu, G., Brown, H., Forsyth, J.L. How great is the survival advantage of transplantation over dialysis in elderly patients? Nephrol. Dial. Transplant 2004; 19:945–951.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ali Alobaidli
  • Sarbjit V. Jassal

There are no affiliations available

Personalised recommendations