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Prevention of Chronic Renal Diseases in the Elderly

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Book cover The Aging Kidney in Health and Disease

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References

  • Incidence and prevalence of ESRD. USRDS. United States Renal Data System. Am. J. Kidney Dis. 1997; 30:S40–53.

    Google Scholar 

  • Usami, T., Koyama, K., Takeuchi, O., Morozumi, K., Kimura, G. Regional variations in the incidence of end-stage renal failure in Japan. JAMA 2000; 284:2622–2624.

    Article  PubMed  CAS  Google Scholar 

  • Disney, A.P. Some trends in chronic renal replacement therapy in Australia and New Zealand. Nephrol. Dial. Transplant. 1998; 13:854–859.

    Article  PubMed  CAS  Google Scholar 

  • Report. Dialysis and Renal Transplantation, Canadian Organ Replacement Register. Ottawa, Ontario: Canadian Institute for Health Information. 2001.

    Google Scholar 

  • Frei, U., Schober-Halstenberg, H.J. Annual Report of the German Renal Registry 1998. QuaSi-Niere Task Group for Quality Assurance in Renal Replacement Therapy. Nephrol. Dial. Transplant 1999; 14:1085–1090.

    Article  PubMed  CAS  Google Scholar 

  • Garcia Lopez, F.J., Robles, R., Gentil, M.A. En presentacion del Grupo de Registros de Enfermos Renales de Espana. Comparacion de la incidencia, prevalencia, modalidades de tratamiento y mortalidad en pacientes con tratamiento renal sustitutivo en cinco communidades autonomas espagnolas en el periodo 1991–1996. Nefrologia 1999; 19:443–459.

    Google Scholar 

  • U.R.R.R. 2000. UK Renal Registry. Bristol, UK.

    Google Scholar 

  • Jungers, P., Choukroun, G., Robino, C., Massy, Z.A., Taupin, P., Labrunie, M., Man, N.K., Landais, P. Epidemiology of end-stage renal disease in the Ile-de-France area: A prospective study in 1998. Nephrol. Dial. Transplant 2000; 15:2000–2006.

    Article  PubMed  CAS  Google Scholar 

  • Stengel, B., Billon, S., Van Dijk, P.C., Jager, K.J., Dekker, F.W., Simpson, K., Briggs, J.D. Trends in the incidence of renal replacement therapy for end-stage renal disease in Europe, 1990–1999. Nephrol. Dial. Transplant 2003; 18:1824–1833.

    Article  PubMed  Google Scholar 

  • McCredie, M. Geographic, ethnic, age-related and temporal variation in the incidence of end-stage renal disease in Europe, Canada and the Asia-Pacific region, 1998–2002. Nephrol. Dial. Transplant 2006; 21:2178–2183.

    Article  PubMed  Google Scholar 

  • Coresh, J., Astor, B.C., Greene, T., Eknoyan, G., Levey, A.S. Prevalence of chronic kidney disease and decreased kidney function in the adult U.S. population: Third National Health and Nutrition Examination Survey. Am. J. Kidney Dis. 2003; 41:1–12.

    Article  PubMed  Google Scholar 

  • Hannedouche, T., Landais, P., Goldfarb, B., el Esper, N., Fournier, A., Godin, M., Durand, D., Chanard, J., Mignon, F., Suo, J.M., et al. Randomised controlled trial of enalapril and beta blockers in non-diabetic chronic renal failure. BMJ 1994; 309:833–837.

    PubMed  CAS  Google Scholar 

  • Bigazzi, R., Bianchi, S., Baldari, D., Campese, V.M. Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension. J. Hypertens. 1998; 16:1325–1333.

    Article  PubMed  CAS  Google Scholar 

  • Magnason, R.L., Indridason, O.S., Sigvaldason, H., Sigfusson, N., Palsson, R. Prevalence and progression of CRF in Iceland: a population-based study. Am. J. Kidney Dis. 2002; 40:955–963.

    Article  PubMed  Google Scholar 

  • Jungers, P., Chauveau, P., Descamps-Latscha, B., Labrunie, M., Giraud, E., Man, N.K., Grunfeld, J.P., Jacobs, C. Age- and gender-related incidence of chronic renal failure in a French urban area: a prospective epidemiologic study. Nephrol. Dial. Transplant 1996; 11:1542–1546.

    PubMed  CAS  Google Scholar 

  • John, R., Webb, M., Young, A., Stevens, P.E. Unreferred chronic kidney disease: A longitudinal study. Am. J. Kidney Dis. 2004; 43:825–835.

    Article  PubMed  Google Scholar 

  • Simal, F., Martin Escudero, J.C., Bellido, J., Arzua, D., Mena, F.J., Gonzalez Melgosa, I., Alvarez Hurtado, A.A., Tabuyo, M.B., Molina, A. [Prevalence of mild to moderate chronic kidney disease in the general population of Spain. Hortega study.] [in Spanish] Nefrologia 2004; 24:329–332, 334, 336–327.

    Google Scholar 

  • National Kidney Foundation K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification and stratification. Am. J. Kidney Dis. 2002; 39(Suppl 1):S1–S266.

    Google Scholar 

  • Glynn, R.J., Chae, C.U., Guralnik, J.M., Taylor, J.O., Hennekens, C.H. Pulse pressure and mortality in older people. Arch. Intern. Med. 2000; 160:2765–2772.

    Article  PubMed  CAS  Google Scholar 

  • Caskey, F.J., Schober-Halstenberg, H.J., Roderick, P.J., Edenharter, G., Ansell, D., Frei, U., Feest, T.G. Exploring the differences in epidemiology of treated ESRD between Germany and England and Wales. Am. J. Kidney Dis. 2006; 47:445–454.

    Article  PubMed  Google Scholar 

  • Sarnak, M.J., Levey, A.S., Schoolwerth, A.C., Coresh, J., Culleton, B., Hamm, L.L., McCullough, P.A., Kasiske, B.L., Kelepouris, E., Klag, M.J., et al. Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003; 108:2154–2169.

    Article  PubMed  Google Scholar 

  • Hansberry, M.R., Whittier, W.L., Krause, M.W. The elderly patient with chronic kidney disease. Adv. Chronic Kidney Dis. 2005; 12:71–77.

    Article  PubMed  Google Scholar 

  • Harris, M.I., Flegal, K.M., Cowie, C.C., Eberhardt, M.S., Goldstein, D.E., Little, R.R., Wiedmeyer, H.M., Byrd-Holt, D.D. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 1998; 21:518–524.

    Article  PubMed  CAS  Google Scholar 

  • Kamper, A.L., Strandgaard, S., Leyssac, P.P. Late outcome of a controlled trial of enalapril treatment in progressive chronic renal failure. Hard end-points and influence of proteinuria. Nephrol. Dial. Transplant 1995; 10:1182–1188.

    PubMed  CAS  Google Scholar 

  • Buemi, M., Nostro, L., Aloisi, C., Cosentini, V., Criseo, M., Frisina, N. Kidney aging: From phenotype to genetics. Rejuvenation Res. 2005; 8:101–109.

    Article  PubMed  CAS  Google Scholar 

  • Burstein, D.M., Korbet, S.M., Schwartz, M.M. Membranous glomerulonephritis and malignancy. Am. J. Kidney Dis. 1993; 22:5–10.

    PubMed  CAS  Google Scholar 

  • Haas, M., Spargo, B.H., Wit, E.J., Meehan, S.M. Etiologies and outcome of acute renal insufficiency in older adults: A renal biopsy study of 259 cases. Am. J. Kidney Dis. 2000; 35:433–447.

    PubMed  CAS  Google Scholar 

  • Modesto-Segonds, A., Ah-Soune, M.F., Durand, D., Suc, J.M. Renal biopsy in the elderly. Am. J. Nephrol. 1993; 13:27–34.

    Article  PubMed  CAS  Google Scholar 

  • Preston, R.A., Stemmer, C.L., Materson, B.J., Perez-Stable, E., Pardo, V. Renal biopsy in patients 65 years of age or older. An analysis of the results of 334 biopsies. J. Am. Geriatr. Soc. 1990; 38:669–674.

    PubMed  CAS  Google Scholar 

  • Davison, A.M. Renal disease in the elderly. Nephron 1998; 80:6–16.

    Article  PubMed  CAS  Google Scholar 

  • Ruggenenti, P., Remuzzi, A., Ondei, P., Fasolini, G., Antiga, L., Ene-Iordache, B., Remuzzi, G., Epstein, F.H. Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease. Kidney Int. 2005; 68:206–216.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, A.M., Gabow, P.A. Identification of patients with autosomal dominant polycystic kidney disease at highest risk for end-stage renal disease. J. Am. Soc. Nephrol. 1997; 8:1560–1567.

    PubMed  CAS  Google Scholar 

  • King, B.F., Reed, J.E., Bergstralh, E.J., Sheedy, P.F., II, Torres, V.E. Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in autosomal dominant polycystic kidney disease. J. Am. Soc. Nephrol. 2000; 11:1505–1511.

    PubMed  CAS  Google Scholar 

  • Klag, M.J., Whelton, P.K., Randall, B.L., Neaton, J.D., Brancati, F.L., Ford, C.E., Shulman, N.B., Stamler, J. Blood pressure and end-stage renal disease in men. N. Engl. J. Med. 1996; 334:13–18.

    Article  PubMed  CAS  Google Scholar 

  • Perneger, T.V., Whelton, P.K., Klag, M.J. History of hypertension in patients treated for end-stage renal disease. J. Hypertens. 1997; 15:451–456.

    Article  PubMed  CAS  Google Scholar 

  • Psaty, B.M., Furberg, C.D., Kuller, L.H., Cushman, M., Savage, P.J., Levine, D., O’Leary, D.H., Bryan, R.N., Anderson, M., Lumley, T. Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: The cardiovascular health study. Arch. Intern. Med. 2001; 161:1183–1192.

    Article  PubMed  CAS  Google Scholar 

  • Benetos, A., Safar, M., Rudnichi, A., Smulyan, H., Richard, J.L., Ducimetieere, P., Guize, L. Pulse pressure: A predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997; 30:1410–1415.

    PubMed  CAS  Google Scholar 

  • Franklin, S.S., Khan, S.A., Wong, N.D., Larson, M.G., Levy, D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study. Circulation 1999; 100:354–360.

    PubMed  CAS  Google Scholar 

  • Chae, C.U., Pfeffer, M.A., Glynn, R.J., Mitchell, G.F., Taylor, J.O., Hennekens, C.H. Increased pulse pressure and risk of heart failure in the elderly. JAMA 1999; 281:634–639.

    Article  PubMed  CAS  Google Scholar 

  • Sesso, H.D., Stampfer, M.J., Rosner, B., Hennekens, C.H., Gaziano, J.M., Manson, J.E., Glynn, R.J. Systolic and diastolic blood pressure, pulse pressure, and mean arterial pressure as predictors of cardiovascular disease risk in men. Hypertension 2000; 36:801–807.

    PubMed  CAS  Google Scholar 

  • Blacher, J., Staessen, J.A., Girerd, X., Gasowski, J., Thijs, L., Liu, L., Wang, J.G., Fagard, R.H., Safar, M.E. Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch. Intern. Med. 2000; 160:1085–1089.

    Article  PubMed  CAS  Google Scholar 

  • Vaccarino, V., Holford, T.R., Krumholz, H.M. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. J. Am. Coll. Cardiol. 2000; 36:130–138.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, A.B., Karter, A.J., Liu, J.Y., Selby, J.V., Schneider, E.C. Use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in high-risk clinical and ethnic groups with diabetes. J. Gen. Intern. Med. 2004; 19:669–675.

    Article  PubMed  Google Scholar 

  • Young, J.H., Klag, M.J., Muntner, P., Whyte, J.L., Pahor, M., Coresh, J. Blood pressure and decline in kidney function: Findings from the Systolic Hypertension in the Elderly Program (SHEP). J. Am. Soc. Nephrol. 2002; 13:2776–2782.

    Article  PubMed  CAS  Google Scholar 

  • Hyman, D.J., Pavlik, V.N. Characteristics of patients with uncontrolled hypertension in the United States. N. Engl. J. Med. 2001; 345:479–486.

    Article  PubMed  CAS  Google Scholar 

  • Hansen, K.J., Edwards, M.S., Craven, T.E., Cherr, G.S., Jackson, S.A., Appel, R.G., Burke, G.L., Dean, R.H. Prevalence of renovascular disease in the elderly: A population-based study. J. Vasc. Surg. 2002; 36:443–451.

    Article  PubMed  Google Scholar 

  • Wild, S., Roglic, G., Green, A., Sicree, R., King, H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047–1053.

    Article  PubMed  Google Scholar 

  • U.S.R.D. System USRDS 2003 Annual Data Report: Atlas of End Stage Renal Disease in the United States. Bethesda, MD: National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2003.

    Google Scholar 

  • Mokdad, A.H., Ford, E.S., Bowman, B.A., Nelson, D.E., Engelgau, M.M., Vinicor, F., Marks, J.S. Diabetes trends in the U.S.: 1990–1998. Diabetes Care 2000; 23:1278–1283.

    Article  PubMed  CAS  Google Scholar 

  • Lee, G. End-stage renal disease in the Asian-Pacific region. Semin. Nephrol. 2003; 23:107–114.

    Article  PubMed  Google Scholar 

  • Van Dijk, P.C., Jager, K.J., Stengel, B., Gronhagen-Riska, C., Feest, T.G., Briggs, J.D. Renal replacement therapy for diabetic end-stage renal disease: Data from 10 registries in Europe (1991–2000). Kidney Int. 2005; 67:1489–1499.

    Article  PubMed  Google Scholar 

  • Anderson, S., Rennke, H.G., Brenner, B.M. Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat. J. Clin. Invest. 1986; 77:1993–2000.

    PubMed  CAS  Google Scholar 

  • Aros, C., Remuzzi, G. The renin-angiotensin system in progression, remission and regression of chronic nephropathies. J. Hypertens. Suppl. 2002; 20:S45–53.

    Article  PubMed  CAS  Google Scholar 

  • Shake, J.G., Brandt, R.C., Daniels, B.S. Angiotensin II induces actine in the polymerization within the glomerular filtration barrier: Possible role in the local regulation of ultrafiltration. J. Am. Soc. Nephrol. 1992; 3:568A.

    Google Scholar 

  • Wolf, G., Kalluri, R., Ziyadeh, F.N., Neilson, E.G., Stahl, R.A. Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells. Proc. Assoc. Am. Physicians 1999; 111:357–364.

    Article  PubMed  CAS  Google Scholar 

  • Zoja, C., Benigni, A., Remuzzi, G. Cellular responses to protein overload: Key event in renal disease progression. Curr. Opin. Nephrol. Hypertens. 2004; 13:31–37.

    Article  PubMed  CAS  Google Scholar 

  • Eddy, A. Role of cellular infiltrates in response to proteinuria. Am. J. Kidney Dis. 2001; 37:S25–29.

    PubMed  CAS  Google Scholar 

  • Agapitov, A.V., Haynes, W.G. Role of endothelin in cardiovascular disease. J. Renin Angiotensin Aldosterone Syst. 2002; 3:1–15.

    Article  PubMed  CAS  Google Scholar 

  • Komatsu, K., Frohlich, E.D., Ono, H., Ono, Y., Numabe, A., Willis, G.W. Glomerular dynamics and morphology of aged spontaneously hypertensive rats. Effects of angiotensin-converting enzyme inhibition. Hypertension 2005; 25:207–213.

    Google Scholar 

  • Frohlich, E.D. Arthus C. Corcoran Memorial Lecture. Influence of nitric oxide and angiotensin II on renal involvement in hypertension. Hypertension 1997; 29:188–193.

    Google Scholar 

  • Harris, P.C., Torres, V.E. Understanding pathogenic mechanisms in polycystic kidney disease provides clues for therapy. Curr. Opin. Nephrol. Hypertens. 2006; 15:456–463.

    Article  PubMed  CAS  Google Scholar 

  • Peterson, J.C., Adler, S., Burkart, J.M., Greene, T., Hebert, L.A., Hunsicker, L.G., King, A.J., Klahr, S., Massry, S.G., Seifter, J.L. Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study. Ann. Intern. Med. 1995; 123:754–762.

    PubMed  CAS  Google Scholar 

  • Wapstra, F.H., Navis, G., de Jong, P.E., de Zeeuw, D. Prognostic value of the short-term antiproteinuric response to ACE inhibition for prediction of GFR decline in patients with nondiabetic renal disease. Exp. Nephrol. 1996; 4 (Suppl 1):47–52.

    PubMed  CAS  Google Scholar 

  • Lewis, E.J., Hunsicker, L.G., Clarke, W.R., Berl, T., Pohl, M.A., Lewis, J.B., Ritz, E., Atkins, R.C., Rohde, R., Raz, I. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N. Engl. J. Med. 2001; 345:851–860.

    Article  PubMed  CAS  Google Scholar 

  • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia). Lancet 1997; 349:1857–1863.

    Google Scholar 

  • Ruggenenti, P., Perna, A., Mosconi, L., Pisoni, R., Remuzzi, G. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. “Gruppo Italiano di Studi Epidemiologici in Nefrologia” (GISEN). Kidney Int. 1998; 53:1209–1216.

    Article  PubMed  CAS  Google Scholar 

  • Jafar, T.H., Schmidt, C.H., Stark, P.C., Landa, M., Maschio, G., Marcantoni, C., De Jong, P.E., De Zeeuw, D., Shahinfar, S., Levey, A.S. The influence of urine protein excretion on benefit of angiotensin-converting enzyme inhibitors in patients with non-diabetic renal disease. J. Am. Soc. Nephrol. 2000; 11:63A.

    Google Scholar 

  • Bakris, G.L., Weir, M.R. Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: Is this a cause for concern? Arch. Intern. Med. 2000; 160:685–693.

    Article  PubMed  CAS  Google Scholar 

  • Ruggenenti, P., Perna, A., Remuzzi, G. ACE inhibitors to prevent end-stage renal disease: When to start and why possibly never to stop: A post hoc analysis of the REIN trial results. Ramipril Efficacy in Nephropathy. J. Am. Soc. Nephrol. 2001; 12:2832–2837.

    PubMed  CAS  Google Scholar 

  • Acone, D., Cante, D., Cillo, F., Giordano, G., Giordano, C. Blood pressure and progression of renal failure in the elderly. Kidney Int. Suppl. 1996; 55:S75–77.

    PubMed  CAS  Google Scholar 

  • Pitt, B., Segal, R., Martinez, F.A., Meurers, G., Cowley, A.J., Thomas, I., Deedwania, P.C., Ney, D.E., Snavely, D.B., Chang, P.I. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 1997; 349:747–752.

    Article  PubMed  CAS  Google Scholar 

  • Ruggenenti, P., Perna, A., Gherardi, G., Gaspari, F., Benini, R., Remuzzi, G. Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in Nephropathy. Lancet 1998; 352:1252–1256.

    Article  PubMed  CAS  Google Scholar 

  • Maschio, G., Alberti, D., Janin, G., Locatelli, F., Mann, J.F., Motolese, M., Ponticelli, C., Ritz, E., Zucchelli, P. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N. Engl. J. Med. 1996; 334:939–945.

    Article  PubMed  CAS  Google Scholar 

  • K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease. Am. J. Kidney Dis. 2004; 43:S1–290.

    Google Scholar 

  • Brenner, B.M., Cooper, M.E., de Zeeuw, D., Keane, W.F., Mitch, W.E., Parving, H.H., Remuzzi, G., Snapinn, S.M., Zhang, Z., Shahinfar, S. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 2001; 345:861–869.

    Article  PubMed  CAS  Google Scholar 

  • Parving, H.H., Lehnert, H., Brochner-Mortensen, J., Gomis, R., Andersen, S., Arner, P. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N. Engl. J. Med. 2001; 345:870–878.

    Article  PubMed  CAS  Google Scholar 

  • Remuzzi, G., Ruggenenti, P., Perna, A., Dimitrov, B.D., de Zeeuw, D., Hille, D.A., Shahinfar, S., Carides, G.W., Brenner, B.M. Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: A post hoc analysis of the RENAAL trial results. J. Am. Soc. Nephrol. 2004; 15:3117–3125.

    Article  PubMed  Google Scholar 

  • Brenner, B.M., Cooper, M.E., de Zeeuw, D., Grunfeld, J.P., Keane, W.F., Kurokawa, K., McGill, J.B., Mitch, W.E., Parving, H.H., Remuzzi, G., et al. The losartan renal protection study—rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan). J. Renin Angiotensin Aldosterone Syst. 2000; 1:328–335.

    Article  PubMed  CAS  Google Scholar 

  • Winkelmayer, W.C., Zhang, Z., Shahinfar, S., Cooper, M.E., Avorn, J., Brenner, B.M. Efficacy and safety of angiotensin II receptor blockade in elderly patients with diabetes. Diabetes Care 2006; 29:2210–2217.

    Article  PubMed  CAS  Google Scholar 

  • Winkelmayer, W.C., Fischer, M.A., Schneeweiss, S., Wang, P.S., Levin, R., Avorn, J. Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes. Am. J. Kidney Dis. 2005; 46:1080–1087.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, A.B., Hamel, M.B., Weinstein, M.C., Cutler, D.M., Fendrick, A.M., Vijan, S. Cost-effectiveness of full Medicare coverage of angiotensin-converting enzyme inhibitors for beneficiaries with diabetes. Ann. Intern. Med. 2005; 143:89–99.

    PubMed  Google Scholar 

  • Ahuja, T.S., Freeman, D., Jr., Mahnken, J.D., Agraharkar, M., Siddiqui, M., Memon, A. Predictors of the development of hyperkalemia in patients using angiotensin-converting enzyme inhibitors. Am. J. Nephrol. 2000; 20:268–272.

    Article  PubMed  CAS  Google Scholar 

  • Ruggenenti, P., Schieppati, A., Remuzzi, G. Progression, remission, regression of chronic renal diseases. Lancet 2001; 357:1601–1608.

    Article  PubMed  CAS  Google Scholar 

  • Parving, H.H. Diabetic nephropathy: Prevention and treatment. Kidney Int. 2001; 60:2041–2055.

    Article  PubMed  CAS  Google Scholar 

  • Fried, L.F., Orchard, T.J., Kasiske, B.L. Effect of lipid reduction on the progression of renal disease: A meta-analysis. Kidney Int. 2001; 59:260–269.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, S.J., Moye, L.A., Sacks, F.M., Johnstone, D.E., Timmis, G., Mitchell, J., Limacher, M., Kell, S., Glasser, S.P., Grant, J., et al. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann. Intern. Med. 1998; 129:681–689.

    PubMed  CAS  Google Scholar 

  • Sacks, F.M., Tonkin, A.M., Shepherd, J., Braunwald, E., Cobbe, S., Hawkins, C.M., Keech, A., Packard, C., Simes, J., Byington, R., et al. Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: The Prospective Pravastatin Pooling Project. Circulation 2000; 102:1893–1900.

    PubMed  CAS  Google Scholar 

  • www.merck.com/mrkshared/mmg/home.jsp. The Merck Manual of Geriatrics. New York, Wiley: Beer MH. 2006.

    Google Scholar 

  • Hostetter, T.H. The next treatments of chronic kidney disease: If we find them, can we test them? J. Am. Soc. Nephrol. 2002; 13:3024–3026.

    Article  PubMed  Google Scholar 

  • Orth, S.R., Stockmann, A., Conradt, C., Ritz, E., Ferro, M., Kreusser, W., Piccoli, G., Rambausek, M., Roccatello, D., Schafer, K., et al. Smoking as a risk factor for end-stage renal failure in men with primary renal disease. Kidney Int. 1998; 54:926–931.

    Article  PubMed  CAS  Google Scholar 

  • Gaede, P., Vedel, P., Larsen, N., Jensen, G.V., Parving, H.H., Pedersen, O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N. Engl. J. Med. 2003; 348:383–393.

    Article  PubMed  Google Scholar 

  • Wolf, G., Ziyadeh, F.N. Renal tubular hypertrophy induced by angiotensin II. Semin. Nephrol. 1997; 17:448–454.

    PubMed  CAS  Google Scholar 

  • Ritz, E., Orth, S.R. Nephropathy in patients with type 2 diabetes mellitus. N. Engl. J. Med. 1999; 341:1127–1133.

    Article  PubMed  CAS  Google Scholar 

  • Hansson, L., Zanchetti, A., Carruthers, S.G., Dahlof, B., Elmfeldt, D., Julius, S., Menard, J., Rahn, K.H., Wedel, H., Westerling, S. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998; 351:1755–1762.

    Article  PubMed  CAS  Google Scholar 

  • Klijn, C.J., Kappelle, L.J., Tulleken, C.A., van Gijn, J. Symptomatic carotid artery occlusion. A reappraisal of hemodynamic factors. Stroke 1997; 28:2084–2093.

    PubMed  CAS  Google Scholar 

  • Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358:1033–1041.

    Google Scholar 

  • Matsumura, M., Nomura, H., Koni, I., Mabuchi, H. Angiotensin-converting enzyme inhibitors are associated with the need for increased recombinant human erythropoietin maintenance doses in hemodialysis patients. Risks of Cardiac Disease in Dialysis Patients Study Group. Nephron 1997; 77:164–168.

    PubMed  CAS  Google Scholar 

  • Schmidt, A., Gruber, U., Bohmig, G., Koller, E., Mayer, G. The effect of ACE inhibitor and angiotensin II receptor antagonist therapy on serum uric acid levels and potassium homeostasis in hypertensive renal transplant recipients treated with CsA. Nephrol. Dial. Transplant 2001; 16:1034–1037.

    Article  PubMed  CAS  Google Scholar 

  • Ruilope, L.M., Aldigier, J.C., Ponticelli, C., Oddou-Stock, P., Botteri, F., Mann, J.F. Safety of the combination of valsartan and benazepril in patients with chronic renal disease. European Group for the Investigation of Valsartan in Chronic Renal Disease. J. Hypertens. 2000; 18:89–95.

    PubMed  CAS  Google Scholar 

  • Nakao, N., Yoshimura, A., Morita, H., Takada, M., Kayano, T., Ideura, T. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial. Lancet 2003; 361:117–124.

    Article  PubMed  CAS  Google Scholar 

  • Jamerson, K.A. Preventing chronic kidney disease in special populations. Am. J. Hypertens. 2005; 18:106S–111S.

    Article  PubMed  Google Scholar 

  • Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA 1991; 265:3255–3264.

    Google Scholar 

  • Staessen, J.A., Fagard, R., Thijs, L., Celis, H., Arabidze, G.G., Birkenhager, W.H., Bulpitt, C.J., de Leeuw, P.W., Dollery, C.T., Fletcher, A.E., et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997; 350:757–764.

    Article  PubMed  CAS  Google Scholar 

  • Chobanian, A.V., Bakris, G.L., Black, H.R., Cushman, W.C., Green, L.A., Izzo, J.L., Jr., Jones, D.W., Materson, B.J., Oparil, S., Wright, J.T., Jr., et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report. JAMA 2003; 289:2560–2572.

    Article  PubMed  CAS  Google Scholar 

  • Marin, R., Gorostidi, M., Fernandez-Vega, F., Alvarez-Navascues, R. Systemic and glomerular hypertension and progression of chronic renal disease: The dilemma of nephrosclerosis. Kidney Int Suppl. 2005; pp. S52–56.

    Google Scholar 

  • Wright, J.T., Jr., Bakris, G., Greene, T., Agodoa, L.Y., Appel, L.J., Charleston, J., Cheek, D., Douglas-Baltimore, J.G., Gassman, J., Glassock, R., et al. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: Results from the AASK trial. JAMA 2002; 288:2421–2431.

    Article  PubMed  CAS  Google Scholar 

  • Segura, J., Campo, C., Rodicio, J.L., Ruilope, L.M. ACE inhibitors and appearance of renal events in hypertensive nephrosclerosis. Hypertension 2001; 38:645–649.

    Article  PubMed  CAS  Google Scholar 

  • Ritz, E. Albuminuria and vascular damage—The vicious twins. N. Engl. J. Med. 2001; 348:2349–2352.

    Article  Google Scholar 

  • Gall, M.A., Hougaard, P., Borch-Johnsen, K., Parving, H.H. Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: Prospective, observational study. BMJ 1997; 314:783–788.

    PubMed  CAS  Google Scholar 

  • Adler, A.I., Stevens, R.J., Manley, S.E., Bilous, R.W., Cull, C.A., Holman, R.R. Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 2003; 63:225–232.

    Article  PubMed  Google Scholar 

  • Perkins, B.A., Ficociello, L.H., Silva, K.H., Finkelstein, D.M., Warram, J.H., Krolewski, A.S. Regression of microalbuminuria in type 1 diabetes. N. Engl. J. Med. 2003; 348:2285–2293.

    Article  PubMed  CAS  Google Scholar 

  • Mogensen, C.E. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N. Engl. J. Med. 1984; 310:356–360.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, R.G., Knowler, W.C., Pettitt, D.J., Saad, M.F., Charles, M.A., Bennett, P.H. Assessment of risk of overt nephropathy in diabetic patients from albumin excretion in untimed urine specimens. Arch. Intern. Med. 1991; 151:1761–1765.

    Article  PubMed  CAS  Google Scholar 

  • Eurich, D.T., Majumdar, S.R., Tsuyuki, R.T., Johnson, J.A. Reduced mortality associated with the use of ACE inhibitors in patients with type 2 diabetes. Diabetes Care 2004; 27:1330–1334.

    Article  PubMed  CAS  Google Scholar 

  • Parving, H.H., Mauer, M., Ritz, E. Diabetic Nephropaty. Philadelphia: Saunders. 2004; pp. 1777–1818.

    Google Scholar 

  • Ravid, M., Brosh, D., Levi, Z., Bar-Dayan, Y., Ravid, D., Rachmani, R. Use of enalapril to attenuate decline in renal function in normotensive, normoalbuminuric patients with type 2 diabetes mellitus. A randomized, controlled trial. Ann. Intern. Med. 1998; 128:982–988.

    PubMed  CAS  Google Scholar 

  • The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT): Design and baseline characteristics. Cont. Clin. Trials 2003; 24:442–461.

    Article  Google Scholar 

  • Ruggenenti, P., Fassi, A., Ilieva, A.P., Bruno, S., Iliev, I.P., Brusegan, V., Rubis, N., Gherardi, G., Arnoldi, F., Ganeva, M., et al. Preventing microalbuminuria in type 2 diabetes. N. Engl. J. Med. 2004; 351:1941–1951.

    Article  PubMed  CAS  Google Scholar 

  • Ruggenenti, P., Perna, A., Ganeva, M., Ene-Iordache, B., Remuzzi, G. Impact of blood pressure control and angiotensin-converting enzyme inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: A post hoc analysis of the BENEDICT trial. J. Am. Soc. Nephrol. 2006; 17:3472–3481.

    Article  PubMed  CAS  Google Scholar 

  • Bakris, G.L., Weir, M.R., Shanifar, S., Zhang, Z., Douglas, J., van Dijk, D.J., Brenner, B.M. Effects of blood pressure level on progression of diabetic nephropathy: Results from the RENAAL study. Arch. Intern. Med. 2003; 163:1555–1565.

    Article  PubMed  Google Scholar 

  • Pohl, M.A., Blumenthal, S., Cordonnier, D.J., De Alvaro, F., Deferrari, G., Eisner, G., Esmatjes, E., Gilbert, R.E., Hunsicker, L.G., de Faria, J.B., et al. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: Clinical implications and limitations. J. Am. Soc. Nephrol. 2005; 16:3027–3037.

    Article  PubMed  CAS  Google Scholar 

  • Remuzzi, G., Macia, M., Ruggenenti, P. Prevention and treatment of diabetic renal disease in type 2 diabetes: The BENEDICT study. J. Am. Soc. Nephrol. 2006; 17:S90–97.

    Article  PubMed  Google Scholar 

  • Mogensen, C.E. Progression of nephropathy in long-term diabetics with proteinuria and effect of initial anti-hypertensive treatment. Scand. J. Clin. Lab. Invest. 1976; 36:383–388.

    Article  PubMed  CAS  Google Scholar 

  • Dillon, J.J. The quantitative relationship between treated blood pressure and progression of diabetic renal disease. Am. J. Kidney Dis. 1993; 22:798–802.

    PubMed  CAS  Google Scholar 

  • Strippoli, G.F., Craig, M., Schena, F.P., Craig, J.C. Antihypertensive agents for primary prevention of diabetic nephropathy. J. Am. Soc. Nephrol. 2005; 16:3081–3091.

    Article  PubMed  CAS  Google Scholar 

  • Arauz-Pacheco, C., Parrott, M.A., Raskin, P. Hypertension management in adults with diabetes. Diabetes Care 2005; 27 (Suppl 1):S65–67.

    Google Scholar 

  • Ruggenenti, P., Remuzzi, G. Time to abandon microalbuminuria? Kidney Int. 2006; 70:1214–1222.

    Article  PubMed  CAS  Google Scholar 

  • Collins, A.J. The hemoglobin link to adverse outcomes. Adv. Stud. Med. 2003; 3:S14–S17.

    Google Scholar 

  • Knowler, W.C., Barrett-Connor, E., Fowler, S.E., Hamman, R.F., Lachin, J.M., Walker, E.A., Nathan, D.M. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 2002; 346:393–403.

    Article  PubMed  CAS  Google Scholar 

  • Tuomilehto, J., Lindstrom, J., Eriksson, J.G., Valle, T.T., Hamalainen, H., Ilanne-Parikka, P., Keinanen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 2001; 344:1343–1350.

    Article  PubMed  CAS  Google Scholar 

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Sharma, S.K., Perico, N., Ruggenenti, P., Remuzzi, G. (2008). Prevention of Chronic Renal Diseases in the Elderly. In: MachasNúñez, J.F., Cameron, J.S., Oreopoulos, D.G. (eds) The Aging Kidney in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72659-5_13

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