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During a maximum contraction of many mixed muscles, it is common to see a 50% reduction of force over a period of a few seconds. This is known as fatigue (Rothwell, 1994). The term fatigue though can refer to both physical and mental exhaustion due to prolonged stimulation or exertion. As such, it is a phenomenon that is of interest to many scientific disciplines, including the science of coaching, as is used in a variety of contexts. Of particular interest is localized progressive muscle fatigue which has been defined as an inability to maintain required force level after prolonged use of muscle (Gandevia et al. 1998). While reduction in force production is obviously detrimental in many circumstances, progressive muscle fatigue has also been shown to impair postural stability (Johnston et al., 1998), muscle coordination (Carpenter et al., 1998) and control of limb velocity and acceleration (Jaric et al., 1997).

Fatigue has traditionally been attributed to the occurrence of a “metabolic endpoint”, where muscle glycogen concentrations are depleted, plasma glucose concentrations are reduced and plasma free fatty acid levels are elevated (cf: Meeusen et al., 2006). However, one of the major complications that arise in studying muscle fatigue is that both peripheral and central mechanisms contribute to the manifestations of muscle fatigue (Enoka & Stuart, 1992). These mechanisms are highly interactive in nature, and should both be acknowledged as a complex phenomenon. Unfortunately, both their independent and collective contributions to progressive muscle fatigue are still poorly understood.

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References

  • Rothwell, J. Control of human voluntary movement. Second edition. Chapman & Hill, 1994. Gandevia, S.C., Enoka, R.M., McComas, A.J., Stuart, D.G., Thams, C.K. (Eds.), Fatigue: neural and muscular mechanisms. New York: Plenum Press, 1998.

    Google Scholar 

  • Johnston, J., Rearick, M., Slobounov, S. (2001). Movement-related cortical potentials associated with progressive muscle fatigue in a grasping task. Clinical Neurophysiology, 112, 68-77.

    Article  CAS  PubMed  Google Scholar 

  • Carpenter, J.E., Blasser, R.B., Pelizzon, G.G. (1998). The effects of muscle fatigue on shoulder joint position sense. American Journal of Sports Medicine, 26, 62-65.

    Google Scholar 

  • Jaric, S., Radovanovic, S., Milanovic, S et al. (1997). A comparison of the effects of agonist and antagonist muscle fatigue on performance of rapid movement. European Journal of Applied Physiology, 76, 41-47.

    Article  CAS  Google Scholar 

  • Meeusen, R., Watson, P., Hasegawa, H., Roelands, B., Piacentini, M. (2006). Central fatigue: The serotonin hypothesis and beyond. Sports Medicine, 36(10), 881-909.

    Article  PubMed  Google Scholar 

  • Enoka, R.M, Stuart, D.G. (1992). Neurobiology of muscle fatigue. Journal of Applied Physiology, 72, 1631-48.

    Article  CAS  PubMed  Google Scholar 

  • Dimeo, F., Stieglitz, R.D., Novelli-Fischer, U., Fetscher, S., Mertelsmann, R., Keul, J. (1997). Correlation between physical performance and fatigue in cancer patients. Annals of Oncology, 8, 1251-1255.

    Article  CAS  PubMed  Google Scholar 

  • Simmonds, M.J. (2002). Physical function in patients with cancer: Psychometric characteristics and clinical usefulness of a physical performance test battery. Journal of Pain Symptom Management, 24, 404-414.

    Article  Google Scholar 

  • Schmid, M., Schieppati M., & Pozzo, T. (2006). Effect of fatigue on the precision of a whole-body pointing task. Neuroscience, 139 (3), 909-20.

    Article  CAS  PubMed  Google Scholar 

  • Apriantono, T., Nunome, H., Ikegami, Y., & Sano, S. (2006). The effect of muscle fatigue on instep kicking kinetics and kinematics in association football. Journal of Sports Science, 24 (9), 951-60.

    Article  Google Scholar 

  • Bergstrom, J., Hermansen, L., Hultman, E. et al. (1967). Diet, muscle glycogen and physical performance. Acta Physiologica Scandinavia, 71(2), 140-150.

    Article  CAS  Google Scholar 

  • Merton, P.A. (1954). Voluntary strength and fatigue. Journal of Physiology, 123, 553-564.

    CAS  PubMed  Google Scholar 

  • Marsden, C.D., Meadows, J.C., & Merton, P.A. (1983). Muscular wisdom that minimizes fatigue during prolonged effort in man: peak rates of motoneuron discharge and slowing of discharge during fatigue. Advanced Neurology, 39, 169-211.

    CAS  Google Scholar 

  • Gandevia, S.C. (2001). Spinal and supraspinal factors in human muscle 309-14 fatigue. Physiological Review, 81 (4), 1725-89.

    CAS  Google Scholar 

  • Todd, G., Taylor, J.T., Butler, J.E., Martin, P.G., Gorman, R.B., Gandevia, S.C. (2007). Use of motor cortex stimulation to measure simultaneously the changes in dynamic muscle properties and voluntary activation in human muscle. Journal of Applied Physiology, 102 (5), 1756-1766.

    Article  PubMed  Google Scholar 

  • Mosso, A. Fatigue. London. Swan Sonnenschein, 1904.

    Google Scholar 

  • Newsholme, E.A., Acworth, I., Bloomstrand, E. (1987). Amino acids, brain neurotransmitters and a function link between muscle and brain that is important in sustained exercise. In: Benzi G (Ed). Advances in myochemistry. pp. 127-133. London: John Libbey Eurotext.

    Google Scholar 

  • Davis, J.M. & Bailey, S.P. (1997). Possible mechanisms of central nervous system fatigue during exercise. Medicine in Science Sports Exercise, 29(1), 45-57.

    CAS  Google Scholar 

  • Taylor, J.L., Butler, J.E., Allen, G.M., Gandevia, S.C. (1996). Changes in motor cortical excitability during human muscle fatigue. Journal of Physiology, 490, 519-529.

    CAS  PubMed  Google Scholar 

  • Sogaard, K., Gandevia, S.C., Todd, G., Petersen, N.T., Taylor, J.L. (2006). The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscles. Journal of Physiology, 573(Pt 2), 511-523.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, A. (2007). Chronic fatigue syndrome: a tiresome illness. British Journal of Nursing, 16(16), 967.

    PubMed  Google Scholar 

  • Ivanova, M. Cortical control of voluntary movement. Moscow: Academy of Science, 1990. (Russian).

    Google Scholar 

  • Freude, G., Ullsperger, P. (1987). Changes in bereitschaftpotential during fatiguing and non-fatiguing hand movement. European Journal of Physiology, 56, 105-108.

    Article  CAS  Google Scholar 

  • Liu, J.Z., Zhang, L.D., Shan, Z.Y., Sahgal, V., Brown, R.W., Yue, G.H. (2003). Brain activation during sustained and intermittent submaximal fatigue muscle contractions. Journal of Neurophysiology, 90, 300-312.

    Article  PubMed  Google Scholar 

  • Kristeva, R., Cheyne, D., Lang, W., Lindenger, G., Deecke, L. (1990). Movement-related potentials accompanying unilateral and bilateral finger movements with different inertial load. EEG and Clinical Neurophysiology, 75, 410-418.

    Article  CAS  Google Scholar 

  • Shibata, M., Oda, S., Moritani, T. (1997). The relationship between movement-related cortical potentials and motor unit activity during motor contraction. Journal of Electromyography and Kinesiology, 7(2), 79-85.

    Article  CAS  PubMed  Google Scholar 

  • Liu, J.Z., Yao, B., Siemionow, V., Sahgal, V., Wang, X.F., Sun, J., Yue, G.H. (2005a). Minimal changes in cortical command but substantial declines in muscular output during severe muscle fatigue. Brain Research, 1057, 113-126.

    Article  CAS  PubMed  Google Scholar 

  • Liu, J.Z., Zhang, L.D., Yao, B., Sahgal, V., Yue, G.H. (2005b). Fatigue induced by intermittent maximal voluntary contractions is associated with significant losses in muscle output but limited reductions in functional MRI-measured brain activation level. Brain Research 1040, 44-54.

    Article  CAS  PubMed  Google Scholar 

  • Zamarian, L., Visani, P., Delazer, M., Seppi, K., et al., (2006). Parkinson’s disease and arithmetics: the role of executive functions. Journal of Neurological Sciences, 25(248), 124-130.

    Article  Google Scholar 

  • Babiloni, F., Babiloni, C., Carducci, F. et al. (2000). Movement-related electroencephalo-graphic reactivity in Alzheimer disease. Neuroimage, 12(2), 139-146.

    Article  CAS  PubMed  Google Scholar 

  • Leocani, L., Colombo, B., Magnani, G. et al. (2001). Fatigue in multiple sclerosis is associated with abnormal cortical activation to voluntary movement: EEG evidence. Neuroimage, 13(6Pt 1), 1186-1192.

    Article  CAS  PubMed  Google Scholar 

  • Bower, J.E. (2005). Prevalence and causes of fatigue after cancer treatment: the next generation of research. Journal of Clinical Oncology, 23(33), 8280-2.

    Article  PubMed  Google Scholar 

  • Reyes-Gibby, C.C., Aday, L.A., Anderson, K.O., Mendoza, T.R., Cleeland, C.S. (2006). Pain, depression, and fatigue in community-dwelling adults with and without history of cancer. Journal of Pain and Symptom Management, 32(2), 118-128.

    Article  PubMed  Google Scholar 

  • Geinitz, H., Zimmermann, F.B., Thammm, R., Keller, M., Busch, R., Molls, M. (2004). Fatigue in patients with adjuvant radiation therapy for breast cancer: long-term follow-up. Journal of Cancer Research and Clinical Oncology, 130(6), 327-333.

    Article  PubMed  Google Scholar 

  • Bower, J.E., Ganz, P.A., Desmond, K.A. et al. (2006). Fatigue in long-term breast carcinoma survivors: A longitudinal investigation. Cancer, 106(4), 751-8.

    Article  PubMed  Google Scholar 

  • Wijesuriya, N., Tran, Y., Craig, A. (2007). The psychophysiological determinants of fatigue. International Journal of Psychophysiology, 63 (1), 77-86.

    Article  PubMed  Google Scholar 

  • Fawkes-Kirby, T.M., Wheeler, M.A., Anton, H.A., Miller, W.C., Townson, A.F., Weeks, C.A. (2007). Clinical correlates of fatigue in spinal cord injury. Spinal Cord

    Google Scholar 

  • Bushnik, T., Englander, J., Katznelson, L. (2007). Fatigue after TBI: association with neuroendocrine abnormalities. Brain Injury, 21 (6), 559-66.

    Article  PubMed  Google Scholar 

  • Borotikar, B.S., Newcomer, R., Koppes, R., McLean S.G. (2007). Combined effects of fatigue and decision making on female lower limb landing postures: Central and peripheral contributions to ACL injury risk. Clinical Biomechanics. Sep 21.

    Google Scholar 

  • Mawston, G.A., McNair P.J., Boocock, M.G. (2007). The effects of prior warning and lifting-induced fatigue on trunk muscle and postural responses to sudden loading during manual handling. Ergonomics, 1-14.

    Google Scholar 

  • McLean, S.G., Felin, R.E., Suedekum, N., Calabrese, G., Passerallo, A., Joy, S. (2007). Impact of fatigue on gender-based high-risk landing strategies. Medicine & Science in Sports & Exercise, 39 (3), 502-14.

    Article  Google Scholar 

  • Larivière, C., Gravel, D., Gagnon, D., Gardiner, P., Bertrand Arsenault, A., Gaudreault, N. (2006). Gender influence on fatigability of back muscles during intermittent isometric contractions: a study of neuromuscular activation patterns. Clinical Biomechanics, 21 (9), 893-904.

    Article  PubMed  Google Scholar 

  • Padua, D.A., Arnold, B.L., Perrin, D.H., Gansneder, B.M., Carcia, C.R., Granata, K.P. (2006). Fatigue, vertical leg stiffness, and stiffness control strategies in males and females. Journal of Athletic Training, 41 (3), 294-304.

    PubMed  Google Scholar 

  • Nyland, J.A., Caborn, D.N., Shapiro, R., Johnson, D.L. (1997). Fatigue after eccentric quadriceps femoris work produces earlier gastrocnemius and delayed quadriceps femoris activation during crossover cutting among normal athletic women. Knee Surgery Sports Traumatology, Arthroscopy, 5 (3), 162-7.

    Article  CAS  Google Scholar 

  • Chappell, J.D., Herman, D.C., Knight, B.S., Kirkendall, D.T., Garrett, W.E., Yu, B. (2005). Effect of fatigue on knee kinetics and kinematics in stop-jump tasks. American Journal of Sports Medicine, 33 (7), 1022-9.

    Article  PubMed  Google Scholar 

  • Kellis, E., Kouvelioti, V. (2007). Agonist versus antagonist muscle fatigue effects on thigh muscle activity and vertical ground reaction during drop landing. Journal of Electromyography and Kinesiology.

    Google Scholar 

  • Holmes, A.M., Andrews, D.M. (2006). The effect of leg muscle activation state and localized muscle fatigue on tibial response during impact. Journal of Applied Biomechanics, 22 (4), 275-84.

    PubMed  Google Scholar 

  • Moran, K.A., Marshall, B.M. (2006). Effect of fatigue on tibial impact accelerations and knee kinematics in drop jumps. Medicine & Science in Sports & Exercise, 38 (10), 1836-42.

    Article  Google Scholar 

  • Granata, K.P., Slota, G.P., Wilson, S.E. (2004). Influence of fatigue in neuromuscular control of spinal stability. Human Factors, 46 (1), 81-91.

    Article  PubMed  Google Scholar 

  • Jackson, N.D., Gutierrez, G.M., Kaminski, T. (2007). The effect of fatigue and habituation on the stretch reflex of the ankle musculature. Journal of Electromyography and Kinesiology.

    Google Scholar 

  • Lattanzio, P.J., Petrella, R.J., Sproule, J.R., Fowler, P.J. (1997). Effects of fatigue on knee proprioception. Clinical Journal of Sports Medicine, 7 (1), 22-7.

    Article  CAS  Google Scholar 

  • Tripp, B.L., Yochem, E.M., Uhl, & T.L. (2007). Functional fatigue and upper extremity sensorimotor system acuity in baseball athletes. Journal of Athletic Training, 42 (1), 90-8.

    Google Scholar 

  • Bowman, T.G., Hart, J.M., McGuire, B.A., Palmieri, R.M., Ingersoll, C.D. (2006). A functional fatiguing protocol and deceleration time of the shoulder from an internal rotation perturbation. Journal of Athletic Training, 41 (3), 275-9.

    PubMed  Google Scholar 

  • Harkins, K.M., Mattacola, C.G., Uhl, T.L., Malone, T.R., McCrory, J.L. (2005). Effects of 2 ankle fatigue models on the duration of postural stability dysfunction. Journal of Athletic Training, 40 (3), 191-4.

    PubMed  Google Scholar 

  • Gribble PA, Hertel J. (2004a). Effect of lower-extremity muscle fatigue on postural control. Archives of Physical Medicine and Rehabilitation, 85(4), 589-92.

    Article  PubMed  Google Scholar 

  • Gribble, P.A., Hertel, J. (2004b). Effect of hip and ankle muscle fatigue on unipedal postural control. Journal of Electromyography and Kinesiology, 14(6), 641-6.

    Article  PubMed  Google Scholar 

  • Gribble PA, Hertel J, Denegar CR, Buckley WE. (2004c). The Effects of Fatigue and Chronic Ankle Instability on Dynamic Postural Control. Journal of Athletic Training, 39 (4), 321-329.

    PubMed  Google Scholar 

  • Gandevia, S.C., Allen, G.M., & McKenzie, D.K. (1995). Central fatigue: critical issues, quantification and practical applications. Advanced Experimental Medical Biology, 384, 281-294.

    CAS  Google Scholar 

  • Barry, B., Enoka, R. (2006). The neurobiology of muscle fatigue: 15 years later. Integrative and Comparative Biology, 47, 465-473.

    Article  Google Scholar 

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(2008). Fatigue-Related Injuries in Athletes. In: Injuries in Athletics: Causes and Consequences. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72577-2_4

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