Central Consequences of Cochlear Trauma

  • D. Kent Morest
  • Steven J. Potashner
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 31)


Hair Cell Sensorineural Hearing Loss Inferior Colliculus Noise Exposure Cochlear Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Axelsson A, Barrenas ML (1992) Tinnitus in noise-induced hearing loss. In: Dancer AL, Henderson D, Salvi RJ, Hamernik RP (eds) Noise-Induced Hearing Loss Boston: Mosby Year Book, pp. 269–276.Google Scholar
  2. Benson CG, Gross JS, Suneja SK, Potashner SJ (1997) Synaptophysin immunoreactivity in the cochlear nucleus after unilateral cochlear or ossicular removal. Synapse 25:243–257.PubMedCrossRefGoogle Scholar
  3. Bilak M, Kim J, Potashner SJ, Bohne BA, Morest DK (1997) New growth of axons in the cochlear nucleus of adult chinchillas after acoustic trauma. Exp Neurol 147:256–268.PubMedCrossRefGoogle Scholar
  4. Bilak MM, Hossain WA, Morest DK (2003) Intracellular fibroblast growth factor (FGF-2) produces different effects than extracellular application on development of cochleo-vestibular ganglion cells in vitro. J Neurosci Res 71:629–647.PubMedCrossRefGoogle Scholar
  5. Bledsoe SC Jr, Nagase S, Miller JM, Altschuler RA (1995) Deafness-induced plasticity in the mature central auditory system. NeuroReport 7:225–229.PubMedGoogle Scholar
  6. Bohne B (1976). Mechanisms of noise damage in the inner ear. In: Henderson D, Hamernik R, Dosanjh DS, Mills JH (eds) Effects of Noise on Hearing. New York: Raven Press, pp. 41–67.Google Scholar
  7. Botcher FA, Salvi RJ. 1993. Functional changes in the ventral cochlear nucleus following acute acoustic overstimulation. J Acoust Soc Am 94: 2123–2134.CrossRefGoogle Scholar
  8. Brozoski TJ, Bauer CA, Caspary DM (2002) Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus. J Neurosci 22: 2383–2390.PubMedGoogle Scholar
  9. Brumwell C, Hossain WA, Morest DK, Bernd P (2000) Role for basic fibroblast growth factor (FGF-2) in tyrosine kinase (Trib.) expression in the early development and innervation of the auditory receptor: in vitro and in situ studies. Exp Neurol 162:121–145.PubMedCrossRefGoogle Scholar
  10. Brumwell C, Hossain WA, Morest DK, Wolf B (2005) Biotinidase reveals the morphogenetic sequence in cochlea and cochlear nucleus of mice. Hear Res 209:104–121.PubMedCrossRefGoogle Scholar
  11. Chang H, Chen K, Kaltenbach JA, Zhang J, Godfrey DA (2002) Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices. Hear Res 164:59–68.PubMedCrossRefGoogle Scholar
  12. Cohen ES, Brawer JR, Morest DK (1972) Projections of the cochlea to the dorsal cochlear nucleus in the cat. Exp Neurol 35:470–479.PubMedCrossRefGoogle Scholar
  13. Diamond ME, Armstrong-James M, Ebner FF (1993) Experience-dependent plasticity in adult rat barrel cortex. PNAS USA 90:2082–2086.PubMedCrossRefGoogle Scholar
  14. Eldredge DH, Miller JD, Bohne BA (1981) A frequency-position map for the chinchilla cochlea. J Acoust Soc Amer 69:1091–1095.CrossRefGoogle Scholar
  15. Erb DE, Povlishock JT (1991) Neuroplasticity following traumatic brain injury: a study of GABAergic terminal loss, and recovery in the cat dorsal lateral vestibular nucleus. Exp Brain Res 83:253–267.PubMedCrossRefGoogle Scholar
  16. Florentine M (1976) Relation between lateralization and loudness in asymmetrical hearing loss. J Am Audiol Soc 1:243–251.PubMedGoogle Scholar
  17. Francis HW, Manis PB (2000) Effects of deafferentation on the electrophysiology of ventral cochlear nucleus neurons. Hear Res 149:91–105.PubMedCrossRefGoogle Scholar
  18. Gerken, GM (1979) Central denervation hypersensitivity in the auditory system of the cat. J Acoust Soc Am 66:721–727.PubMedCrossRefGoogle Scholar
  19. Gerken GM, Saunders SS, Paul RE (1984) Hypersensitivity to electrical stimulation of auditory nuclei follows hearing loss in cats. Hear Res 13:249–259.PubMedCrossRefGoogle Scholar
  20. Gerken GM, Saunders SS, Simhadri-Sumithra R, Bhat KH (1985) Behavioral thresholds for electrical stimulation applied to auditory brainstem nuclei in cat are altered by injurious and noninjurious sound. Hear Res 20:221–231.PubMedCrossRefGoogle Scholar
  21. Goldberger ME, Murray M (1985) Recovery of function, and anatomical plasticity after damage to the adult, and neonatal spinal cord. In: Cotman CW (ed) Synaptic Plasticity New York: Guilford Press, pp. 77–110.Google Scholar
  22. Hossain WA, Morest DK (2000) Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: immunohistochemistry and antibody perturbation. J Neurosci Res 62:40–55.PubMedCrossRefGoogle Scholar
  23. Hossain WA, Zhou X, Rutledge A, Baier C, Morest DK (1995) Basic fibroblast growth factor affects neuronal migration and differentiation in normotypic cell cultures from the cochleovestibular ganglion of the chick embryo. Exp Neurol 138:121–143.CrossRefGoogle Scholar
  24. Hossain WA, Rutledge A, Morest DK (1997) Critical periods of basic fibroblast growth factor and brain-derived neurotophic factor in the development of the chicken cochleovestibular ganglion in vitro. Exp Neurol 147:437–451.PubMedCrossRefGoogle Scholar
  25. Hossain WA, Brumwell CL, Morest DK (2002) Sequential interactions of FGF-2, BNF, NT-3 and their receptors define critical periods in the development of cochlear ganglion cells. Exp Neurol 175:138–151.PubMedCrossRefGoogle Scholar
  26. Hossain WA, D’Sa C, Morest DK (2006) Site-specific interactions of neurotrophin-3 and fibroblast growth factor (FGF2) in the embryonic development of the mouse cochlear nucleus. J Neurobiol 66:897–915.PubMedCrossRefGoogle Scholar
  27. Imig TJ, Durham D (2005) Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat. J Comp Neurol 490:391–413.PubMedCrossRefGoogle Scholar
  28. Jastreboff PJ (1990) Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res 8:221–254.PubMedCrossRefGoogle Scholar
  29. Jastreboff PJ, Jastreboff MM (2002) Tinnitus and hyperacusis. In: Ballenger JJ,Snow JB Jr (eds) Ballenger’s Otorhinolaryngology, Head and Neck Surgery, 16th ed. San Diego: Singular, pp. 456–471.Google Scholar
  30. Johnson J (1975) A fine structural study of degenerative-regenerative pathology in the surgically deafferented vestibular nucleus of the rat. Acta Neuropath (Berlin) 33: 227–243.CrossRefGoogle Scholar
  31. Kaltenbach JA, Afman CE (2000) Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: a physiological model for tinnitus. Hear Res 140:165–172.PubMedCrossRefGoogle Scholar
  32. Kaltenbach JA, McCaslin DL (1996) Increases in spontaneous activity in the dorsal cochlear nucleus following exposure to high intensity sound: a possible neural correlate of tinnitus. Auditory Neurosci 3:57–78.Google Scholar
  33. Kaltenbach JA, Zhang J, Finlayson P (2005) Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Hear Res 206:200–226.PubMedCrossRefGoogle Scholar
  34. Kim J, Morest DK, Bohne B (1997) Degeneration of axons in the brain stem of the chinchilla after auditory overstimulation. Hear Res 103:169–191.PubMedCrossRefGoogle Scholar
  35. Kim JJ, J Gross, SJ Potashner, DK Morest (2004a) Fine structure of degeneration in the cochlear nucleus of the chinchilla following acoustic overstimulation. J Neurosci Res 77:798–816.CrossRefGoogle Scholar
  36. Kim JJ, Gross J, Potashner SJ, Morest DK (2004b) Fine structure of long-term changes in the cochlear nucleus following acoustic overstimulation: chronic degeneration and new growth of synaptic endings. J Neurosci Res 77:817–828.CrossRefGoogle Scholar
  37. Kim JJ, J Gross J, DK Morest, SJ Potashner (2004c) A quantitative study of degeneration and new growth of axons and synaptic endings in the chinchilla cochlear nucleus following acoustic overstimulation. J Neurosci Res 77:829–842.Google Scholar
  38. Kimura M, Eggermont JJ (1999) Effect of acute pure tone induced hearing loss on response properties in three auditory cortical fields in cat. Hear Res 135:146–162.PubMedCrossRefGoogle Scholar
  39. Komiya H, Eggermont JJ (2000) Spontaneous firing activity of cortical neurons in adult cats with reorganized tonotopic map following pure-tone trauma. Acta Oto-Laryngologica 6:750–756.Google Scholar
  40. Kudoh M, Shibuki K (1996) Long-term potentiation of supragranular pyramidal outputs in the rat auditory cortex. Exp Brain Res 110:21–27.PubMedCrossRefGoogle Scholar
  41. LaMotte CC, Kapadia SE (1993) Deafferentation-induced terminal field expansion of myelinated saphenous afferents in the adult rat dorsal horn, and the nucleus gracilis following pronase injection of the sciatic nerve. J Comp Neurol 330:83–94.PubMedCrossRefGoogle Scholar
  42. Merzenich MM, Kaas JH, Wall JT, Sur M, Nelson RJ, Felleman DJ (1983) Progression of change following median nerve section in the cortical representation of the hand in areas 3b, and 1 in adult owl, and squirrel monkeys. Neuroscience 10: 639–665.PubMedCrossRefGoogle Scholar
  43. Milbrandt JD, Holder TM, Wilson MC, Salvi RJ, Caspary DM (2000) GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma. Hear Res 147:251–260.PubMedCrossRefGoogle Scholar
  44. Mo Z, Suneja SK, Potashner SJ (2006) Phosphorylated cAMP response element-binding protein levels in guinea pig brainstem auditory nuclei after unilateral cochlear ablation. J Neurosci Res 83:1323–1330.PubMedCrossRefGoogle Scholar
  45. Moore DR (1993) Plasticity of binaural hearing and some possible mechanisms following late-onset deprivation. J Am Acad Audiol 4:277–283.PubMedGoogle Scholar
  46. Morest DK (1982) Degeneration in the brain following exposure to noise. In: Hamernik RP, Henderson D, Salvi R (eds) New Perspectives in Noise Induced Hearing Loss. New York: Raven Press, pp. 87–93.Google Scholar
  47. Morest DK (1997) Structural basis for signal processing in the mammalian cochlear nuclei. Challenge of the synaptic nests. In: Syka J (ed) The Mammalian Cochlear Nuclei: Organization and Function. New York: Plenum Press, pp. 19–32.Google Scholar
  48. Morest DK, Ard MD, Yurgelun-Todd D (1979) Central auditory pathways sensitive to acoustic over-stimulation in the cat. Assoc Res Otolaryngol Abstr 2:28–29.Google Scholar
  49. Morest DK. Jones DR, Kwok S, Ard MD, Bohne B, Yurgelun-Todd D (1987) Response of the brain to acoustic damage of the cochlea. Assoc Res Otolaryngol Abstr 10:3.Google Scholar
  50. Morest DK, Kim J, Bohne B (1997) Neuronal and transneuronal degeneration of auditory axons in the brain stem after cochlear lesions in the chinchilla: cochleotopic and non-cochleotopic patterns. Hear Res 103:151–168.PubMedCrossRefGoogle Scholar
  51. Morest DK, J Kim, SJ Potashner, BA Bohne (1998) Long-term degeneration in the cochlear nerve and cochlear nucleus of the adult chinchilla. Special Issue on Plasticity in the Central Auditory System Microsc Res Tech 41:205–216.Google Scholar
  52. Muly SM, Gross JS, Morest DK, Potashner SJ (2002) Synaptophysin in the cochlear nucleus following acoustic trauma. Exp Neurol 177:202–221.PubMedCrossRefGoogle Scholar
  53. Muly SM, Gross JS, Potashner SJ (2004) Noise trauma alters d-[4H]aspartate release and AMPA binding in chinchilla cochlear nucleus. J Neurosci Res 75:585–596.PubMedCrossRefGoogle Scholar
  54. Olson WO, Noffsinger D, Kurdziel S (1975) Speech discrimination in quiet and in white noise by patients with peripheral and central lesions. Acta Otolaryngol 80:375–382.CrossRefGoogle Scholar
  55. Osen KK (1970) Course and termination of the primary afferents in the cochlear nuclei of the cat. An experimental anatomical study. Arch Ital Biol 108:21–51.PubMedGoogle Scholar
  56. Potashner SJ, Suneja SK, Benson CG (1997) Regulation of d-aspartate release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. Exp Neurol 148:222–235.PubMedCrossRefGoogle Scholar
  57. Potashner SJ, Suneja SK, Benson CG (2000) Altered glycinergic synaptic activities in guinea pig brain stem auditory nuclei after unilateral cochlear ablation. Hear Res 147:125–136.PubMedCrossRefGoogle Scholar
  58. Prosen CA, Moody DB, Sommers MS, Stebbins WC (1990) Frequency discrimination in the monkey. J Acoust Soc Am 88:2152–2158.PubMedCrossRefGoogle Scholar
  59. Rajan R, Irvine DRF, Wise LZ, Heil P (1993) Effect of unilateral partial cochlear lesions in adult cats on the representation of lesioned, and unlesioned cochleas in primary auditory cortex. J Comp Neurol 338:17–49.PubMedCrossRefGoogle Scholar
  60. Rasmussen GL (1990) Spiral ganglion lesions, notebook 1, pp. 1–58. Research Notebooks, History of Medicine Division, National Library of Medicine, ACC 653.Google Scholar
  61. Rasmussen GL, RR Gacek, McCrane EP, Baker CC (1960) Model of cochlear nucleus (cat) displaying its afferent and efferent connections. Anat Rec 136:344.Google Scholar
  62. Recanzone GH, Schreiner CE, Merzenich MM (1993) Plasticity in the frequency representation of primary auditory cortex following discrimination training in adult owl monkeys. J Neurosci 13:87–103.PubMedGoogle Scholar
  63. Robertson D, Irvine DRF (1989) Plasticity of frequency organization in auditory cortex of guinea pigs with partial unilateral deafness. J Comp Neurol 282:456–471.PubMedCrossRefGoogle Scholar
  64. Salvi RJ, Powers NL, Saunders SS, Botcher FA, Clock AE (1992) Enhancement of evoked response amplitude and single unit activity after noise exposure. In: Dancer A, Henderson D, Salvi RJ, Hamernik RP (eds) Effects of noise on the auditory system. St. Louis: Mosby Year Book, pp. 156–171.Google Scholar
  65. Salvi RJ, Wang J, Ding D (2000) Auditory plasticity and hyperactivity following cochlear damage. Hear Res 147:261–274.PubMedCrossRefGoogle Scholar
  66. Sato K, Shiraishi S, Nakagawa H, Kuriyama H, Altschuler RA (2002) Diversity and plasticity in amino acid receptor subunits in the rat auditory brain stem. Hear Res 147:137–144.CrossRefGoogle Scholar
  67. Saunders JC, Cohen YE, Szymko YM (1991) The structural and functional consequences of acoustic injury in the cochlea and peripheral auditory system: A five year update. J Acoust Soc Am 90:136–146.PubMedCrossRefGoogle Scholar
  68. Smith L, Gross J, Morest DK (2002) Fibroblast growth factors (FGFs) in the cochlear nucleus of the adult mouse following acoustic overstimulation. Hear Res 169:1–12.PubMedCrossRefGoogle Scholar
  69. Suneja SK, Potashner SJ (2003) ERK and SAPK signaling in auditory brainstem neurons after unilateral cochlear ablation. J Neurosci Res 73:235–245.PubMedCrossRefGoogle Scholar
  70. Suneja SK, Benson CG, Potashner SJ (1998a) Glycine receptors in adult guinea pig brain stem auditory nuclei: regulation after unilateral cochlear ablation. Exp Neurol 154:473–488.CrossRefGoogle Scholar
  71. Suneja SK, Potashner SJ, Benson CG (1998b) Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. Exp Neurol 151:273–288.CrossRefGoogle Scholar
  72. Suneja SK, Potashner SJ, Benson CG (2000) AMPA receptor binding in adult guinea pig brain stem auditory nuclei after unilateral cochlear ablation. Exp Neurol 165:355–369.PubMedCrossRefGoogle Scholar
  73. Suneja SK, Yan L, Potashner SJ (2005) Regulation of NT-3 and BNF levels in guinea pig auditory brain stem nuclei after unilateral cochlear ablation. J Neurosci Res 80: 381–390.PubMedCrossRefGoogle Scholar
  74. Syka J (2002) Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev 82:601–636.PubMedGoogle Scholar
  75. Wailed JF, Lu SM (1982) Noise-induced hearing loss can alter neural coding and increase excitability in the central nervous system. Science 216:1331–1334.CrossRefGoogle Scholar
  76. Webster DB, Webster M (1978) Cochlear nerve projections following organ of Corti destruction. Otolaryngology 86:342–353.Google Scholar
  77. Weinberger NM (1993) Learning-induced changes of auditory receptive fields. Curr Opin Neurobiol 3:570–577.PubMedCrossRefGoogle Scholar
  78. Yan L, Suneja SK, Potashner SJ (2006) Protein kinases regulate glycine receptor binding in brain stem auditory nuclei after unilateral cochlear ablation. Brain Res doi:10.1016/j.brainres.2006. 12.013Google Scholar
  79. Zhang J, Suneja SK, Potashner SJ (2002) Protein kinase C regulates d-[3H]aspartate release in auditory brain stem nuclei. Exp Neurol 175:245–256.PubMedCrossRefGoogle Scholar
  80. Zhang J, Suneja SK, Potashner SJ (2003a) Protein kinase A and calcium/calmodulin-dependent protein kinase II regulate d-[3H]aspartate release in auditory brain stem nuclei. J Neurosci Res 74:81–90.CrossRefGoogle Scholar
  81. Zhang J, Suneja SK, Potashner SJ (2003b) Protein kinase C regulation of glycine and UP gamma-aminobutyric acid release in brain stem auditory nuclei. Exp Neurol 182:75–86.CrossRefGoogle Scholar
  82. Zhang J, Suneja SK, Potashner SJ (2004) Protein kinase A and calcium/calmodulin-dependent protein kinase II regulate glycine and GABA release in auditory brain stem nuclei. J Neurosci Res 75:361–370.PubMedCrossRefGoogle Scholar
  83. Zhou X, Hossain WA, Rutledge D, Baier , C, Morest DK (1996) Basic fibroblast growth factor (FGF-2) affects development of acoustico-vestibular neurons in the chick embryo brain in vitro. Hear Res 101:186–207.CrossRefGoogle Scholar
  84. Zwislocki J, Maire F, Feldman AS, Rubin H (1958) On the effect of practice and motivation on the threshold of audibility. J Acoust Soc Am 30:254–262.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • D. Kent Morest
  • Steven J. Potashner

There are no affiliations available

Personalised recommendations