Skip to main content

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 31))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alam SA, Ikeda K, Oshima T, Suzuki M, Kawase T, Kikuchi T, Takasaka T (2000) Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea. Hear Res 141:28–38.

    PubMed  CAS  Google Scholar 

  • Albinger-Hegyi A, Hegyi I, Nagy I, Bodmer M, Schmid S, Bodmer D (2006) Alteration of activator protein 1 DNA binding activity in gentamicin-induced hair cell degeneration. Neuroscience137:971–980.

    PubMed  CAS  Google Scholar 

  • Aran JM, Darrouzet J (1975) Observation of click-evoked compound VIII nerve responses before, during and over seven months after kanamycin treatment in the guinea pig. Acta Otolaryngol 79:24–32.

    PubMed  CAS  Google Scholar 

  • Arbuzova A, Martushova K, Hangyas-Mihalyne G, Morris AJ, Ozaki S, Prestwich GD, McLaughlin S (2000) Fluorescently labeled neomycin as a probe of phosphatidylinositol-4,5-bisphosphate in membranes. Biochimica Biophys Acta 1464:35–48.

    CAS  Google Scholar 

  • Barron SE, Daigneault EA (1987) Effect of cisplatin on hair cell morphology and lateral wall Na, K-ATPase activity. Hear Res 26:131–137.

    PubMed  CAS  Google Scholar 

  • Battaglia A, Pak K, Brors D, Bodmer D, Frangos JA, Ryan AF (2003) Involvement of ras activation in toxic hair cell damage of the mammalian cochlea. Neuroscience 122:1025–1035.

    PubMed  CAS  Google Scholar 

  • Bertolini P, Lassalle M, Mercier G, Raquin MA, Izzi G, Corradini N, Hartmann O (2004) Platinum compound-related ototoxicity in children. Long-term follow-up reveals continuous worsening of hearing loss. J Pediatr Hematol Oncol 26:649–655.

    PubMed  Google Scholar 

  • Black FO, Pesznecker S, Stallings V (2004) Permanent gentamicin vestibulotoxicity. Otol Neurotol 25:559–596.

    PubMed  Google Scholar 

  • Blakley BW (1997) Clinical forum: a review of intratympanic therapy. Am J Otol 18:520–526.

    PubMed  CAS  Google Scholar 

  • Blakley BW, Gupta AK, Myers SF, Schwan S (1994) Risk factors for ototoxicity due to cisplatin. Arch Otolaryngol Head Neck Surg 120:541–546.

    PubMed  CAS  Google Scholar 

  • Benedetti Panici P, Greggi S, Scambia G, Baiocchi G, Lomonaco M, Conti G, Mancuso S (1993) Efficacy and toxicity of very high-dose cisplatin in advanced ovarian carcinoma: 4-year survival analysis and neurological follow-up. Int J Gynecol Cancer 3:44–53.

    PubMed  Google Scholar 

  • Bock GR, Yates GK, Miller JJ, Moorjani P (1983) Effects of N-acetylcysteine on kanamycin ototoxicity in the guinea pig. Hear Res 9:255–262.

    PubMed  CAS  Google Scholar 

  • Bodmer D, Brors D, Bodmer M, Ryan AF (2002a) Rescue of auditory hair cells from ototoxicity by CEP-11 004, an inhibitor of the JNK signaling pathway. Laryngorhinootologie 81:853–856.

    CAS  Google Scholar 

  • Bodmer D, Brors D, Pak K, Gloddek B, Ryan A (2002b) Rescue of auditory hair cells from aminoglycoside toxicity by Clostridium difficile toxin B, an inhibitor of the small GTPases Rho/Rac/Cdc42. Hear Res 172:81–86.

    CAS  Google Scholar 

  • Boheim K, Bichler E (1985) Cisplatin-induced ototoxicity: audiometric findings and experimental cochlear pathology. Arch Otorhinolaryngol 242:1–6.

    PubMed  CAS  Google Scholar 

  • Bokemeyer C, Berger CC, Hartmann JT, Kollmannsberger C, Schmoll HJ, Kuczyk MA, Kanz L (1998) Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br J Cancer 77:1355–1362.

    PubMed  CAS  Google Scholar 

  • Bose RN (2002) Biomolecular targets for platinum antitumor drugs. Mini Rev Med Chem 2:103–111.

    PubMed  CAS  Google Scholar 

  • Boulikas T, Vougiouka M (2004) Recent clinical trials using cisplatin, carboplatin and their combination chemotherapy drugs (review). Oncol Rep 11:559–565.

    PubMed  CAS  Google Scholar 

  • Brouet G, Marche J, Chevallier J, Liot F, LE Meur G, Bergogne (1959) Étude expérimentale et clinique de la kanmycine dans l’infection tuberculeuse. Re Tub Pneum 23:949–988.

    Google Scholar 

  • Campbell KCM, Rybak LP, Meech RP, Hughes L (1996) D-Methionine provides excellent protection from cisplatin ototoxicity in the rat. Hear Res 102:90–98.

    PubMed  CAS  Google Scholar 

  • Campbell KC, Meech RP, Rybak LP (1999) D-Methionine protects against cisplatin damage to the stria vascularis. Hear Res 138:13–28.

    PubMed  CAS  Google Scholar 

  • Caussé R, Gondet I, Vallancien B (1949) Action de la streptomycine sur les cellules ciliées des organes vestibulaires de la souris. Compt Rend Soc Biol 143:619–620.

    Google Scholar 

  • Cheng AG, Cunningham LL, Rubel EW (2003) Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation. J Assoc Res Otolaryngol 4:91–105.

    PubMed  Google Scholar 

  • Cheng AG, Cunningham LL, Rubel EW (2005) Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg 13:343–348.

    PubMed  Google Scholar 

  • Choe WT, Chinosornvatana N, Chang KW (2004) Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactate. Otol Neurotol 25:910–915.

    PubMed  Google Scholar 

  • Church MW, Blakley BW, Burgio DL, Gupta AK (2004) WR-2721 (amifostine) ameliorates cisplatin-induced hearing loss but causes neurotoxicity in hamsters. J Assoc Res Otolaryngol 5:227–237.

    PubMed  Google Scholar 

  • Clerici WJ, Hensley K, DiMartino DL, Butterfield DA (1996) Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 98:116–124.

    PubMed  CAS  Google Scholar 

  • Corrado AP, de Morais IP, Prado WA (1989) Aminoglycoside antibiotics as a tool for the study of the biological role of calcium ions. Historical overview. Acta Physiol Pharmacol Latinoamer 39:419–430.

    CAS  Google Scholar 

  • Cunningham LL, Matsui JI, Warchol ME, Rubel EW (2004) Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro. J Neurobiol 60:89–100.

    PubMed  CAS  Google Scholar 

  • Dai CF, Mangiardi D, Cotanche DA, Steyger PS (2006) Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo. Hear Res 213:64–78.

    PubMed  CAS  Google Scholar 

  • Darrouzet J, Guilhaume A (1974) Ototoxicité de la kanamycine au jour le jour. Étude expérimentale en microscopie électronique. Rev Laryng (Bordeaux) 95:601–621.

    CAS  Google Scholar 

  • Davis H, Deatherage BH, Rosenblut B, Fernandez C, Kimura R, Smith CA (1958) Modification of cochlear potentials produced by streptomycin poisoning and by extensive venous obstruction. Laryngoscope 68:596–627.

    PubMed  CAS  Google Scholar 

  • de Jager P, van Altena R (2002) Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis. Int J Tuberc Lung Dis 6:622–627.

    PubMed  Google Scholar 

  • DeConti RC, Toftness BR, Lange RC, Creasey A (1973) Clinical and pharmacological studies with cis-diamminedichloroplatinum (II). Cancer Res 33:1310–1315.

    PubMed  CAS  Google Scholar 

  • DeGroot JC, Hamers FP, Gispen WH, Smoorenberg GF (1997) Co-administration of the neurotropic ACTH (4-9) analogue, ORG 2766, may reduce the cochleotoxic effects of cisplatin. Hear Res 106:9–19.

    CAS  Google Scholar 

  • Dehne N, Lautermann J, Petrat F, Rauen U, de Groot H (2001) Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals. Toxicol Appl Pharmacol 174:27–34.

    PubMed  CAS  Google Scholar 

  • Dehne N, Rauen U, de Groot H, Lautermann J (2002). Involvement of the mitochondrial permeability transition in gentamicin ototoxicity. Hear Res 169:47–55.

    PubMed  CAS  Google Scholar 

  • Devarajan P, Savoca M, Castaneda MP, Park MS, Esteban-Cruciani N, Kalinec G, Kalinec F (2002) Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways. Hear Res 174:45–54.

    PubMed  CAS  Google Scholar 

  • Ding D, Stracher A, Salvi RJ (2002) Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res. 2002 164:115–26. Erratum in: Hear Res. 2003 180:129.

    CAS  Google Scholar 

  • Dulon D, Aran JM, Zajic G, Schacht J (1986) Comparative pharmacokinetics of gentamicin, netilmicin and amikacin in the cochlea and the vestibule of the guinea pig. Antimicrob Agents Chemother 30:96–100.

    PubMed  CAS  Google Scholar 

  • Dulon D, Zajic G, Aran JM, Schacht J (1989) Aminoglycoside antibiotics impair calcium-entry but not viability and motility of cochlear outer hair cells. J Neurosci Res 24:338–346.

    PubMed  CAS  Google Scholar 

  • Dulon D, Hiel H, Aurousseau C, Erre JP, Aran JM (1993) Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence. C.R. Acad Sci III 316:682–687.

    CAS  Google Scholar 

  • Ekborn A, Hansson J, Ehrsson H, Eksborg S, Wallin I, Wagenius G, Laurell G. (2004) High dose cisplatin with amifostine: ototoxicity and pharmacokinetics. Laryngoscope 114:1660–1667.

    PubMed  CAS  Google Scholar 

  • Estrem SA, Babin RW, Ryu JH, Moore KC (1981) Cis-diamminedichloroplatinum (II) ototoxicity in the guinea pig. Otolaryngol Head Neck Surg 89:638–645.

    PubMed  CAS  Google Scholar 

  • Fausti SA, Henry JA, Schaffer HI, Olson DJ, Frey RH, McDonald WJ (1992) High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. J Infect Dis165:1026–1032.

    PubMed  CAS  Google Scholar 

  • Fausti SA, Frey RH, Henry JA, Olson DJ, Schaffer HI (1993) High-frequency monitoring for early detection of cisplatin ototoxicity. Arch Otolaryngol Head Neck Surg 119:661–666.

    PubMed  CAS  Google Scholar 

  • Federspil P (1979) Antibiotikaschöden des Ohres. Barth: Leipzig.

    Google Scholar 

  • Fee WE (1980) Aminoglycoside ototoxicity in the human. Laryngoscope 40:1–19.

    Google Scholar 

  • Feun LG, Wallace S, Stewart DJ, Chuang VP, Yung WK, Leavens ME, Burgess MA, Savaraj N, et al. (1984) Intracarotid infusion of cis-dichlorodiammineplatinum (II) in the treatment of recurrent malignant brain tumors. Cancer 54:794–799.

    PubMed  CAS  Google Scholar 

  • Fischel-Ghodsian N (2005) Genetic factors in aminoglycoside toxicity. Pharmacogenomics 6:27–36.

    PubMed  CAS  Google Scholar 

  • Fleischman RW, Stadnicki SW, Ethier MF, Schaeppi U (1975) Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig. Toxicol Appl Pharmacol 33:320–332.

    PubMed  CAS  Google Scholar 

  • Forge A, Li L (2000) Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 139:97–115.

    PubMed  CAS  Google Scholar 

  • Forge A, Schacht J (2000) Aminoglycoside Antibiotics. Audiol Neurootol 5:3–22.

    PubMed  CAS  Google Scholar 

  • Forge A, Fradis M (1985) Structural abnormalities in the stria vascularis following chronic gentamicin treatment. Hear Res 20:233–244.

    PubMed  CAS  Google Scholar 

  • Forge A, Wright A, Davies SJ (1987) Analysis of structural changes in the stria vascularis following chronic gentamicin treatment. Hear Res 31:253–266.

    PubMed  CAS  Google Scholar 

  • Forge A, Li L, Corwin JT, Nevill G (1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 259:1616–1619.

    PubMed  CAS  Google Scholar 

  • Forge A, Li L, Nevill G (1998) Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs. J Comp Neurol 397:69–88.

    PubMed  CAS  Google Scholar 

  • Fuertes MA, Castilla J, Alonso C, Perez JM (2003) Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem 10:257–266.

    CAS  Google Scholar 

  • Garetz SL, Altschuler RA, Schacht J (1994a) Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 77:81–87.

    CAS  Google Scholar 

  • Gonzalez VM, Fuertes MA, Alonso C, Perez JM (2001) Is cisplatin-induced cell death always produced by apoptosis? Mol Pharmacol 59:657–663.

    PubMed  CAS  Google Scholar 

  • Gormley PE, Bull JM, LeRoy AF, Cysyk R (1979) Kinetics of cis-dichlorodiammine-platinum. Clin Pharmacol Ther 25:351–357.

    PubMed  CAS  Google Scholar 

  • Grunberg SM, Sonka S, Stevenson LL, Muggia FM (1989) Progressive paresthesias after cessation of therapy with very high-dose cisplatin. Cancer Chemother Pharmacol 2:62–64.

    Google Scholar 

  • Halmagyi GM, Fattore CM, Curthoys IS, Wade S (1994) Gentamicin vestibulotoxicity. Otolaryngol Head Neck Surg 111:571–574.

    PubMed  CAS  Google Scholar 

  • Hamasaki K, Rando RR (1997) Specific binding of aminoglycosides to a human rRNA construct based on a DNA polymorphism which causes aminoglycoside-induced deafness. Biochem 36:12323–12328.

    CAS  Google Scholar 

  • Hawkins JE (1973) Ototoxic mechanisms: a working hypothesis. Audiology 12:383–393.

    PubMed  Google Scholar 

  • Hawkins JE (1976) Drug ototoxicity. In: Keidel WD, Neff WD (eds) Handbook of Sensory Physiology. Berlin: Springer Verlag, 5(3) pp. 707–748.

    Google Scholar 

  • Hawkins JE, Beger V, Aran JM (1967) Antibiotic insults to Corti’s organ. In: Graham AB (ed) Sensorineural Hearing Processes and Disorders. Boston: Little Brown Co, pp. 411–425.

    Google Scholar 

  • Henley CM, Schacht J (1988) Pharmacokinetics of aminoglycoside antibiotics in blood, inner ear fluids and tissues and their relationship to ototoxicity. Audiology 27:137–146.

    PubMed  Google Scholar 

  • Henry KR, Chole RA, McGinn MD, Frush DP (1981) Increased ototoxicity in both young and old mice. Arch Otolaryngol 107:92–95.

    PubMed  CAS  Google Scholar 

  • Hershko, C (1992) Iron chelators in medicine. Molec Asp Med 13:113–165.

    CAS  Google Scholar 

  • Himmelstein KJ, Patton TF, Belt RJ, Taylor S, Repta AJ, Sternson LA (1981) Clinical kinetics on intact cisplatin and some related species. Clin Pharmacol Ther 29:658–664.

    PubMed  CAS  Google Scholar 

  • Hinojosa R, Lerner SA (1987) Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. J Infect Dis 156:449–555.

    PubMed  CAS  Google Scholar 

  • Hinojosa R, Riggs LC, Strauss M, Matz GJ (1995) Temporal bone histopathology of cisplatin ototoxicity. Am J Otol 16:731–740.

    PubMed  CAS  Google Scholar 

  • Hinshaw HC, Feldman WH (1945) Streptomycin in treatment of clinical tuberculosis: a preliminary report. Proc Mayo Clinic 20:313–318.

    Google Scholar 

  • Hirose K, Hockenberry DN, Rubel EW (1997) Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 104:1–14.

    PubMed  CAS  Google Scholar 

  • Hirose K, Westrum LE, Stone JS, Zirpel L, Rubel EW (1999) Dynamic studies of ototoxicity in mature avian auditory epithelium. Ann NY Acad Sci 884:389–409.

    PubMed  CAS  Google Scholar 

  • Hoistad DL, Ondrey FG, Mutlu C, Schachern PA, Paparella MM, Adams GL (1998) Histopathology of human temporal bone after cis-platinum, radiation, or both. Otolaryngol Head Neck Surg 118:825–832.

    PubMed  CAS  Google Scholar 

  • Hu DN, Qui WQ, Wu BT, Fang LZ, Zhou F, Gu YP, Zhang QH, Yan JH, et al. (1991) Genetic aspects of antibiotic induced deafness: mitochondrial inheritance. J Med Genet 28:79–83.

    PubMed  CAS  Google Scholar 

  • Huang DC, Strasser A (2000) BH-3-Only proteins—essential initiators of apoptotic cell death. Cell 103:839–842.

    PubMed  CAS  Google Scholar 

  • Imamura S, Adams JC (2003) Distribution of gentamicin in the guinea pig inner ear after local or systemic application. JARO 4:176–195.

    PubMed  Google Scholar 

  • Iraz M, Kalcioglu MT, Kizilay A, Karatas E (2005) Aminoguanidine prevents ototoxicity induced by cisplatin in rats. Ann Lab Clin Sci 35:329–335.

    CAS  Google Scholar 

  • Ishida S, Lee J, Thiele DJ, Herskowita I (2002) Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 99:14298–14302.

    PubMed  CAS  Google Scholar 

  • Jiang H, Sha SH, Schacht J (2005) The NF-UP kappa B pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. J Neurosci Res 79:644–651.

    PubMed  CAS  Google Scholar 

  • Jiang H, Sha SH, Forge A, Schacht J (2006a) Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Diff 13:20–30.

    CAS  Google Scholar 

  • Jiang H, Sha SH, Schacht J (2006b) Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J Neurosci Res 83:1544–1551.

    CAS  Google Scholar 

  • Johnsson LG, Hawkins JE Jr, Kingsley TC, Black FO, Matz GJ (1981) Aminoglycoside-induced cochlear pathology in man. Acta Otolaryngol S383:1–19.

    CAS  Google Scholar 

  • Kalinec GM, Webster P, Lim DJ, Kalinec F (2003) A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol 8:177–189.

    PubMed  CAS  Google Scholar 

  • Kalinec GM, Fernandez-Zapico ME, Urrutia R, Esteban-Cruciani N, Chen S, Kalinec F (2005) Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. Proc Natl Acad Sci USA 102:16019–16024.

    PubMed  CAS  Google Scholar 

  • Kawai Y, Kohda Y, Kodawara T, Gemba M (2005) Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1). J Toxicol Sci 30:157–122.

    PubMed  CAS  Google Scholar 

  • Kawamoto K, Sha SH, Minoda R, Izumikawa M, Kuriyama H, Schacht J, Raphael Y (2004) Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Mol Ther 9:173–181.

    PubMed  CAS  Google Scholar 

  • Kelly TC, Whitworth CA, Husain K, Rybak LP (2003) Aminoguanidine reduces cisplatin ototoxicity. Hear Res 186:10–16

    PubMed  CAS  Google Scholar 

  • Klis SF, O’Leary SJ, Hamers FP, De Groot JC, Smoorenburg GF (2000) Reversible cisplatin ototoxicity in the albino guinea pig. Neuro Report 11:623–626.

    CAS  Google Scholar 

  • Knoll C, Smith RJH, Shores C, Blatt J (2006) Hearing genes and cisplatin deafness: a pilot study. Laryngoscope 116:72–74.

    PubMed  CAS  Google Scholar 

  • Komune S, Ide M, Nakano T, Morimitsu T (1987) Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions. ORL 49:9–16.

    Article  PubMed  CAS  Google Scholar 

  • Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, et al. (1997) The use of organotypic cultures of Corti’s organ to study the protective effects of antioxidant molecules on cisplatin induced damage of auditory hair cells. Am J Otol 18:559–571.

    PubMed  CAS  Google Scholar 

  • Kossl M, Richardson GP, Russell IJ (1990) Stereocilia bundle stiffness: effects of neomycin, A23187 and concanavalin A. Hear Res 44:217–230.

    PubMed  CAS  Google Scholar 

  • Kovach JS, Moertel CG, Schutt AJ, Reitemeier RG, Hahn RG (1973) Phase II study of cis-diamminedichloroplatinum (NSC-119875) in advanced carcinoma of the large bowel. Cancer Chemother Rep 57:357–359.

    PubMed  CAS  Google Scholar 

  • Kroese ABA, van den Bercken J (1982) Effects of ototoxic antibiotices on sensory hair cell functioning. Hear Res 6:183–197.

    Google Scholar 

  • Kroese ABA, Das A, Hudspeth AJ (1989) Blockage of the transduction channels of hair cells in the bull frog’ sacculus by aminoglycoside antibiotics. Hear Res 37:203–218.

    PubMed  CAS  Google Scholar 

  • Ladrech S, Guitton M, Saido T, Lenoir M (2004) Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol 477:149–60.

    PubMed  CAS  Google Scholar 

  • Laurell G, Bagger-Sjoback D (1991) Dose-dependent inner ear changes after IV administration of cisplatin. J Otolaryngol 20:158–167.

    PubMed  CAS  Google Scholar 

  • Laurell G, Jungnelius U (1990) High-dose cisplatin treatment: hearing loss and plasma concentrations. Laryngoscope 100:724–734.

    PubMed  CAS  Google Scholar 

  • Lautermann J, McLaren J, Schacht J (1995) Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear Res 86:15–24.

    PubMed  CAS  Google Scholar 

  • Leake PA, Hradek GT (1988) Cochlear pathology of long term neomycin induced deafness in cats. Hear Res 33:11–33.

    PubMed  CAS  Google Scholar 

  • Lee JE, Nakagawa T, Kim TS, Endo T, Shiga A, Iguchi F, Lee SH, Ito J (2004a) Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment. Acta Otolaryngol 124:1131–1135.

    CAS  Google Scholar 

  • Lee JE, Nakagawa T, Kim TS, Endo T, Shiga A, Iguchi F, Lee SH, Ito J (2004b) Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis. ORL 66, 111–118.

    CAS  Google Scholar 

  • Leist M, Jööttelö M (2001) Four deaths and a funeral: from caspases to alternative mechanisms. Nat Revs 2:1–10.

    Google Scholar 

  • Lerner SA, Schmitt BA, Seligsoh, Matz R (1986) Comparative-study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Am J Med 80:98–104.

    Google Scholar 

  • Lesniak W, Pecoraro VL , Schacht J (2005)Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chem Res Toxicol 18:357–364.

    PubMed  CAS  Google Scholar 

  • Li G, Sha SH, Zotova E, Arezzo J, Van de Water T, Schacht J (2002) Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. Lab Invest 82:585–596.

    PubMed  CAS  Google Scholar 

  • Li L, Nevill G, Forge A (1995) Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig. J Comp Neurol 355:405–417.

    PubMed  CAS  Google Scholar 

  • Li Y, Womer RB, Silber JH (2004) Predicting cisplatin ototoxicity in children: the influence of age and cumulative dose. Eur J Cancer 40:2445–2451.

    PubMed  CAS  Google Scholar 

  • Liang F, Schulte BA, Qu C, Hu W. (2005) Inhibition of the calcium- and voltage-dependent big conductance potassium channel ameliorates cisplatin-induced apoptosis in spiral ligament fibrocytes of the cochlea. Neuroscience 135:263–271.

    PubMed  CAS  Google Scholar 

  • Liedert B, Pluim D, Schellens J, Thomale J (2006) Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei. Nucleic Acids Res 34:[epub March 29, 2006].

    Google Scholar 

  • Lim D (1986) Effects of noise and ototoxic drugs at the cellular level in the cochlea: a review. Am J Otolaryngol 7:73–99.

    PubMed  CAS  Google Scholar 

  • Lindemann HH (1969) Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acat Otolaryngol 67:177–189.

    Google Scholar 

  • Lippman AJ, Helson C, Helson L, Krakoff IH (1973) Clinical trials of cis-diammine- dichloroplatinum (NSC-119875). Cancer Chemother Rep 57:191–200.

    PubMed  CAS  Google Scholar 

  • Liu W, Staecker H, Stupak H, Malgrange B, Lefebvre P, Van De Water TR. (1998) Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuro Report 9:2609–2614.

    CAS  Google Scholar 

  • Lu YF (1987) Cause of 611 deaf mutes in schools for deaf children in Shanghai. Shanghai Med J 10:159.

    Google Scholar 

  • Lynch ED, Gu R, Pierce C, Kil J (2005a) Reduction of acute cisplatin ototoxicity in rats by oral administration of allopurinol and ebselen. Hear Res 201: 81–89.

    CAS  Google Scholar 

  • Lynch ED, Gu R, Pierce C, Kil J (2005b) Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity. Anticancer Drugs 16: 569–579.

    CAS  Google Scholar 

  • Magnet S, Blanchard JS (2005) Molecular insights into aminoglycoside action and resistance. Chem Rev 105:477–497.

    PubMed  CAS  Google Scholar 

  • Mangiardi DA, McLaughlin-Williamson K, May KE, Messana EP, Mountain DC, Cotanche DA (2004) Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment. J Comp Neurol 475:1–18.

    PubMed  CAS  Google Scholar 

  • Marco-Algarra J, Basterra J, Marco J (1985) Cis-diaminedichloroplatinum ototoxicity. An experimental study. Acta Otolaryngol 99:343–347.

    PubMed  CAS  Google Scholar 

  • Marcotti W, van Netten S, Kros CJ (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters hairs through the mechano-electrical transducer channels. J Physiol 576:505–521.

    Google Scholar 

  • Marina N, Chang KW, Malogolowkin M, London WB, Frazier AL, Womer RB, Rescorla F, Billmire DF, et al. (2005) Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children’s Oncology Group study. Cancer 104:841–847.

    PubMed  CAS  Google Scholar 

  • Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E Jr, Murphy CA, Bartlett BA, Finn JP, et al. (1998) Motoneuron apoptosis is blocked by CEP-1347 (KT 7515): a novel inhibitor of the JNK signaling pathway. J Neurosci 18:104–111.

    PubMed  CAS  Google Scholar 

  • Marot M, Uziel A, Romand R (1980) Ototoxicity of kanamycin in developing rats: relationship with the onset of the auditory function. Hear Res 2:111–113.

    PubMed  CAS  Google Scholar 

  • Mathog RH, Klein Jr WJ (1969) Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia. N Engl J Med 280:1223–1224.

    PubMed  CAS  Google Scholar 

  • Matsui JI, Gale JE, Warhol ME (2004) Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro. J Neurobiol 61:250–266.

    PubMed  CAS  Google Scholar 

  • McDonald LJ, Mamrack MD (1995) Phosphoinositide hydrolysis by phospholipase C modulated by multivalent cations La(3+), Al(3+), neomycin, polyamines, and melttin. J Lipid Mediat Cell Signal 11:81–91.

    PubMed  CAS  Google Scholar 

  • McHugh PJ, Spanswick VJ, Hartley JA (2001) Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance. Lancet Oncol 2:483–490.

    PubMed  CAS  Google Scholar 

  • Meech RP, Campbell KC, Hughes LF, Rybak LP (1998) A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis. Hear Res 124:44–59.

    PubMed  CAS  Google Scholar 

  • Minami SB, Sha SH, Schacht J (2004) Antioxidant protection in a new animal model of cisplatin-induced ototoxicity. Hear Res 198:137–143.

    PubMed  CAS  Google Scholar 

  • Mizuta K, Saito A, Watanabe T, Nagura M, Arakawa M, Shimizu F, Hoshino T (1999) Ultrastructural localization of megalin in the cochlear duct. Hear Res 129:83–91.

    PubMed  CAS  Google Scholar 

  • Moestrup SK, Cui S, Vorum H, Bregenga°rd C, Bjrn SE, Norris K, Gliemann J, Christensen EI (1995) Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest 96:1404–1413.

    PubMed  CAS  Google Scholar 

  • Moore RD, Smith CR, Lietman PS (1984) Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. J Infect Dis 149:23–30.

    PubMed  CAS  Google Scholar 

  • Mukherjea D, Whitworth CA, Nandish S, Dunaway GA, Rybak LP, Ramkumar V (2006) Expression of the kidney injury molecule (KIM) 1 in the rat cochlea and induction by cisplatin. Neuroscience 139:733–740.

    PubMed  CAS  Google Scholar 

  • Mulheran M, Degg C, Burr S, Morgan DW, Stableforth DE (2001) Occurrence and risk of cochleotoxicity in cystic fibrosis patients receiving repeated high-dose aminoglycoside therapy. Antimicrob Agents Chemother 45:2502–2509.

    PubMed  CAS  Google Scholar 

  • Myers SF, Blakley BW, Schwan S (1993) Is cis-platinum vestibulotoxic? Otolaryngol Head Neck Surg 108:322–328.

    PubMed  CAS  Google Scholar 

  • Nadol JB Jr (1997) Patterns of neural degeneration in the human cochlea and auditory nerve: implications for cochlear implantation. Otolaryngol Head Neck Surg 117:220–228.

    PubMed  Google Scholar 

  • Nakagawa T, Yamane H, Takayama M, Sunami K, Nakai Y (1998) Apoptosis of guinea pig cochlear hair cells following aminoglycoside treatment. Eur Arch Otorhinolaryngol 255:127–131.

    PubMed  CAS  Google Scholar 

  • Ohtsuki K, Ohtani I, Aikawa T, Sato Y (1982) The ototoxicity and the accumulation in the inner ear fluids of the various aminoglycoside antibiotics. Ear Res Jap 13:85–87.

    Google Scholar 

  • Okuda T, Sugahara K, Takemoto T, Shimogori H, Yamashita H. (2005) Inhibition of caspases alleviates gentamicin-induced cochlear damage in guinea pigs. Auris Nasus Larynx 32:33–37.

    PubMed  Google Scholar 

  • Oren M (1999) Regulation of the p53 tumor suppressor protein. J Biol Chem 274: 36031–36034.

    PubMed  CAS  Google Scholar 

  • Osborn MT, Chambers TC (1996) Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J Biol Chem 271:30950–30955.

    PubMed  CAS  Google Scholar 

  • Peters U, Preisler-Adams S, Lanvers-Kaminsky C, Jürgens H, Lamprecht-Dinnesen A (2003) Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Res 23:1249–1255.

    PubMed  CAS  Google Scholar 

  • Pichler M, Wang Z, Grabner-Weiss C, Reimer D, Hering S, Grabner M, Glossmann H, Striessnig J (1996) Plock of P/Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics. Biochemistry 35:14659–14664.

    PubMed  CAS  Google Scholar 

  • Pierson MG, Moller AR (1981) Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant. Hear Res 4:79–87.

    PubMed  CAS  Google Scholar 

  • Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J (2000) Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT-7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 20:43–50.

    PubMed  CAS  Google Scholar 

  • Pong AL, Bradley JS (2005) Guidelines for the selection of antibacterial therapy in children. Pediatr Clin North Am 52:869–894.

    PubMed  Google Scholar 

  • Prezant TR, Agapian JV, Bohlman MC, Bu X Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, et al. (1993) Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Gen 4:289–294.

    CAS  Google Scholar 

  • Prim MP, de Diego JI, de Sarria MJ, Gavilan J (2001) Vestibular and oculomotor changes in subjects treated with cisplatin. Acta Otorrinolaringol Esp 52:367–370.

    PubMed  CAS  Google Scholar 

  • Priuska EM, Schacht J (1995) Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50:1749–1752.

    PubMed  CAS  Google Scholar 

  • Raphael Y, Fein A, Nebel L (1983) Transplacental kanamycin ototoxicity in the guinea pig. Arch Oto-Rhino-Laryngol 238:45–51.

    CAS  Google Scholar 

  • Ravi R, Somani SM, Rybak LP (1995) Mechanism of cisplatin ototoxicity: antioxidant defense system. Pharmacol Toxicol 76:386–394.

    Article  PubMed  CAS  Google Scholar 

  • Reser D, Rho M, Dewan D, Herbst L Li G, Stupak H, Zur K, Romaine J, et al. (1999) l- and d-methioniine provide long-term protection against CDDP-induced ototoxicity in vivo, with partial in vivo and in vitro retention of antineoplastic activity. Neurotoxicology 20:731–748.

    PubMed  CAS  Google Scholar 

  • Richardson GP, Forge A, Kros CJ, Fleming J, Brown SD, Steel KP (1997) Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. J Neurosci 17:9506–9519.

    PubMed  CAS  Google Scholar 

  • Rosenberg B (1973) Platinum coordination complexes in cancer chemotherapy. Naturwissenschaften 60:399–406.

    PubMed  CAS  Google Scholar 

  • Rosenberg B (1980) Cisplatin: its history and possible mechanisms of action. In: Prestayko, AW, Crooke ST, Carter SK (eds) Cisplatin: Current Status and New Developments. New York: Academic Press, pp. 9–20.

    Google Scholar 

  • Rosenberg B, Van Camp L, Krigas T (1965) Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205:698–699.

    PubMed  CAS  Google Scholar 

  • Rosenberg B, Van Camp L, Trosko JE, Mansour VH (1969) Platinum compounds: a new class of potent antitumor agents. Nature 222:385–386.

    PubMed  CAS  Google Scholar 

  • Rozencweig M, Von Hoff DD, Slavik M, Muggia FM (1977) Cis-ciamminechloro-platinum (II): a new anticancer drug. Ann Intern Med 86:803–812.

    PubMed  CAS  Google Scholar 

  • Ruedi L, Furrer W, Graf K, Luthy F, Nager G, Tschirren B (1951) Nouvelles constatations sur la toxicité de la streptomycine et de la quinine à l‘égard de l’oreille du cobaye. Rev Laryngol (Bordeaux) 72:238–264.

    CAS  Google Scholar 

  • Ruedi L, Furrer W, Graf K, Nager G, Tschirren B, Luthy F (1952) Further observations concerning the toxic effects of streptomycin and quinine on the auditory organ of guinea pigs. Laryngoscope 62:333–357.

    PubMed  CAS  Google Scholar 

  • Rybak LP, Whitworth CA (2005) Ototoxicity: therapeutic opportunities. Drug Discovery Today, 10:1313–1321.

    PubMed  CAS  Google Scholar 

  • Rybak LP, Husain K, Morris C, Whitworth C, Somani S (2000) Effect of protective agents against cisplatin ototoxicity. Am J Otol 21:513–520.

    PubMed  CAS  Google Scholar 

  • Santoso JT, Lucci JA 3rd, Coleman RL, Schafer I, Hannigan EV (2003) Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial. Cancer Chemother Pharmacol 52:13–18.

    PubMed  CAS  Google Scholar 

  • Sastry J, Kellie SJ (2005) Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine. Pediatr Hematol Oncol 22:441–445.

    PubMed  CAS  Google Scholar 

  • Schacht J (1979) Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney. Arch Otorhinolaryngol 224:129–134

    PubMed  CAS  Google Scholar 

  • Schacht J, Hawkins JE (2006) Sketches of Otohistory. Part 11: Ototoxicity: Drug-induced hearing loss. Audiol Neurotol 11:1–6.

    Google Scholar 

  • Schatz A, Bugie E, Waksman SA (1944) Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc Soc Exp Biol Med 55:66–69.

    CAS  Google Scholar 

  • Schuknecht HF (1993) Pathology of the Ear. Philadelphia: Lea & Febiger, pp. 273–274.

    Google Scholar 

  • Schweitzer VG (1993) Ototoxicity of chemotherapeutic agents. Otolaryngol Clin North Am 26: 759–785.

    PubMed  CAS  Google Scholar 

  • Sergi B, Ferraresi A, Troiani D, Paludetti G, Fetoni AR (2003) Cisplatin ototoxicity in the guinea pig: vestibular and cochlear damage. Hear Res 182:56–64.

    PubMed  CAS  Google Scholar 

  • Sha SH, Schacht J (1999a) Formation of reactive oxygen species following bioactivation of gentamicin. Free Radic Biol Med 26:341–347.

    CAS  Google Scholar 

  • Sha SH, Schacht J (1999b) Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 79:807–813.

    CAS  Google Scholar 

  • Sha SH, Qiu JH, Schacht J (2006) Aspirin attenuates gentamicin-induced hearing loss. New Engl J Med 354:1856–1857.

    PubMed  CAS  Google Scholar 

  • Sha SH, Zajic G, Epstein CJ, Schacht J (2001) Overexpression of SOD protects from kanamycin-induced hearing loss. Audiol Neuro-Otol 6:117–123.

    CAS  Google Scholar 

  • Shani J, Bertram J, Russell C, Dahalan R, Chen DC, Parti R, Ahmadi J, Kempf RA, et al. (1989) Noninvasive monitoring of drug distribution and metabolism: studies with intraarterial Pt-195m-cisplatin in humans. Cancer Res 49:1877–1881.

    PubMed  CAS  Google Scholar 

  • Shimizu A, Takumida M, Anniko M, Suzuki M (2003) Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta Otolaryngol 123:459–465.

    PubMed  CAS  Google Scholar 

  • Sone M, Schachern PA, Paparella MM (1998) Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity. Hear Res 115:217–223.

    PubMed  CAS  Google Scholar 

  • Song BB, Schacht J (1996) Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 94:87–93.

    PubMed  CAS  Google Scholar 

  • Song BB, Sha SH, Schacht J (1998) Iron chelators protect from aminoglycoside-induced cochleo- and vestibulotoxicity in guinea pig. Free Radical Biol Med 25:189–195.

    CAS  Google Scholar 

  • Steyger PS (2005) Cellular uptake of aminoglycosides. Volta Rev 105:299–324.

    Google Scholar 

  • Strauss M, Towfighi J, Lord S, Lipton A, Harvey HA, Brown B (1983) Cis-platinum ototoxicity: clinical experience and temporal bone histopathology. Laryngoscope 93:1554–1559.

    PubMed  CAS  Google Scholar 

  • Swan SK (1997) Aminoglycoside nephrotoxicity. Semin Nephrol 17:27–33.

    PubMed  CAS  Google Scholar 

  • Taguchi T, Nazneen A, Abid MR, Razzaque MS (2005) Cisplatin-associated nephrotoxicity and pathological events. Contrib Nephrol 148:107–121.

    PubMed  CAS  Google Scholar 

  • Talley RW, O’Bryan RM, Gutterman JU, Brownlee RW, McCredie KB (1973) Phase I clinical trial of platinum diamminedichloro-cis (NSC-119875). Cancer Chemother Rep 57:465–471.

    PubMed  CAS  Google Scholar 

  • Tan CT, Hsu CJ, Lee SY, Liu SH, Lin-Shiau SY (2001) Potentiation of noise-induced hearing loss by amikacin in guinea pigs. Hear Res 161:72–80.

    PubMed  CAS  Google Scholar 

  • Tanswell AK, Freeman BA (1995) Antioxidant therapy in critical care medicine. New Horizons 3:330–341.

    PubMed  CAS  Google Scholar 

  • Tono T, Kiyomizu K, Matsuda K, Komune S, Usami S, Abe S, Shinkawa H. (2001) Different clinical characteristics of aminoglycoside-induced profound deafness with and without the 1555 A–>G mitochondrial mutation. ORL 63:25–30.

    PubMed  CAS  Google Scholar 

  • Tran Ba Huy P, Bernard P, Schacht J (1986) Kinetics of gentamicin uptake and release in the rat: comparison of inner ear tissues and fluids with other organs. J Clin Invest 77:1492–1500.

    PubMed  CAS  Google Scholar 

  • Tsukasaki N, Whitworth CA, Rybak LP (2000) Acute changes in cochlear potentials due to cisplatin. Hear Res 149:189–198.

    PubMed  CAS  Google Scholar 

  • Umapathi T, Chaudhry V (2005) Toxic neuropathy. Curr Opin Neurol 18:574–580.

    PubMed  CAS  Google Scholar 

  • Vakulenko SB, Mobashery S (2003) Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev 16:430–450.

    PubMed  CAS  Google Scholar 

  • van Ruijven MWM (2004) The cochlear targets of cisplatin. Thesis, University of Utrecht.

    Google Scholar 

  • van Ruijven MWM, De Groot JCMJ, Klis SFL, Smoorenburg G (2005a) Cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study. Hear Res 205: 241–248.

    Google Scholar 

  • van Ruijven MWM, De Groot JCMJ, Smoorenburg GF (2005b) Time sequence of degeneration pattern in the guinea pig cochlea during cisplatin administration. A quantitative histological study. Hear Res 197:44–54.

    Google Scholar 

  • Vermorken JB, Kapteijn TS, Hart AA, Pinedo HM (1983) Ototoxicity of cis-diammine- dichloroplatinum (II): influence of dose, schedule and mode of administration. Eur J Cancer Clin Oncol 19:53–58.

    PubMed  CAS  Google Scholar 

  • Vermorken JB, van der Vijgh WJ, Klein I, Hart AA, Gall HE, Pinedo HM (1984) Pharmacokinetics of free and total platinum species after short-term infusion of cisplatin. Can Treat Rep 68:505–513.

    CAS  Google Scholar 

  • Vital-Brazil O and Corrado AP (1957) The curariform action of streptomycin. J Pharm Exp Ther 120:452–459.

    Google Scholar 

  • Wang D, Lippard SJ (2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4:307–320.

    PubMed  CAS  Google Scholar 

  • Wang J, Lloyd Faulconbridge RV, Fetoni A, Guitton MJ, Pujol R, Puel JL (2003) Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig. Neuropharmacol 45:380–393.

    CAS  Google Scholar 

  • Wang J, Ladrech S, Pujol R, Brabet P, Van De Water TR, Puel JL (2004) Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment prevents cisplatin-induced hearing loss. Cancer Res 64: 9217–9224.

    PubMed  CAS  Google Scholar 

  • Ward DT, Maldonado-Perez D, Hollins L, Riccardi D (2005) Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor. J Am Soc Nephrol 16:1236–1244.

    PubMed  CAS  Google Scholar 

  • Watanabe K, Inai S, Jinnouchi K, Baba S, Yagi T (2003) Expression of caspase-activated deoxyribonuclease (CAD) and caspase-3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs. Auris Nasis Larynx 30: 219–225.

    Google Scholar 

  • Webster M, Webster DB (1981) Spiral ganglion neuron loss following organ of Corti loss: A quantitative study. Brain Res 212:17–30.

    PubMed  CAS  Google Scholar 

  • Wei X, Zhao L, Liu J, Dodel RC, Farlow MR, Du Y (2005) Minocycline prevents gentamicin-induced ototoxicity by inhibiting p38 MAP kinase phosphorylation and caspase 3 activation. Neuroscience 131:513–521.

    PubMed  CAS  Google Scholar 

  • Wersöll J, Lundquist PG, Björkroth B (1969) Ototoxicity of gentamicin. J Infect Dis 119:410–416.

    Google Scholar 

  • Wersöll J, Björkroth B, Flock A, Lundquist PG (1973) Experiments on ototoxic effects of antibiotics. Adv Oto-Rhino-Laryng 20:14–41.

    Google Scholar 

  • Williams SE, Smith DE, Schacht J (1987) Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochem Pharmacol 36:89–95.

    PubMed  CAS  Google Scholar 

  • World Health Organization (2005) WHO Report 2005. global Tuberculosis Control: surveillance, planning, financing. Geneva: World Health Organization.

    Google Scholar 

  • Wright CG, Schaefer SD (1982) Inner ear histopathology in patients treated with cis-platinum. Laryngoscope 92:1408–1413.

    PubMed  CAS  Google Scholar 

  • Wrzesniok D, Buszman E, Karna E, Palka J (2005) Melanin potentiates kanamycin-induced inhibition of collagen biosynthesis in human skin fibroblasts. Pharmazie 60:439–443.

    PubMed  CAS  Google Scholar 

  • Wu WJ, Sha SH, McLaren JD, Kawamoto K, Raphael Y, Schacht J (2001) Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hear Res 158:165–178.

    PubMed  CAS  Google Scholar 

  • Ylikoski, J, Pirvola, U, Suoqiang, Z, Eriksson, U, Solin, M-L, Miettinen, A, (1997) Aminoglycoside ototoxicity: high affinity receptors are expressed in secretory epithelia. Aud Neurosci 3:415–424.

    CAS  Google Scholar 

  • Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U (2002) Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 163:71–61.

    PubMed  CAS  Google Scholar 

  • Zappia JJ, Altschuler RA (1989) Evaluation of the effect of ototopical neomycin on spiral ganglion cell density in the guinea pig. Hear Res 40:29–38.

    PubMed  CAS  Google Scholar 

  • Zhang M, Liu W, Ding D, Salvi R (2003) Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience 120:191–205.

    PubMed  CAS  Google Scholar 

  • Zhang S, Zhao C, Yu L (1997) [Analysis of sensorineural hearing loss in 77 children]. Lin Chuang Erh Pi Yen Hou Ko Tsa Chih Journal of Clinical Otorhinolaryngology 11:252–254.

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Rybak, L.P., Talaska, A.E., Schacht, J. (2008). Drug-Induced Hearing Loss. In: Schacht, J., Popper, A.N., Fay, R.R. (eds) Auditory Trauma, Protection, and Repair. Springer Handbook of Auditory Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72561-1_8

Download citation

Publish with us

Policies and ethics