Advertisement

Age-Related Hearing Loss and Its Cellular and Molecular Bases

  • Kevin K. Ohlemiller
  • Robert D. Frisina
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 31)

Keywords

Hearing Loss Hair Cell Cochlear Implant Inferior Colliculus Noise Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen PD, Burkard RF, Ison JR, Walton JP (2003) Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hear Res 186:17–29.PubMedGoogle Scholar
  2. Ates NA, Unal M, Tamer L, Derici E, Karakas S, Ercan B, Camdevirin H (2005) Glutathione S-transferase gene polymorphisms in presbycusis. Otol Neurotol 26:392–397.PubMedGoogle Scholar
  3. Axellson A, Lindgren F (1985) Is there a relationship between hypercholesterolemia and noise-induced hearing loss? Acta Otolaryngol 100:379–386.Google Scholar
  4. Bai U, Seidman MD, Hinojosa R, Quirk WS (1997) Mitochondrial DNA deletions associated with aging and possibly presbycusis: A human archival temporal bone study. Am J Otol 18:449–453.PubMedGoogle Scholar
  5. Banay-Schwartz, M, Lajtha A, Palkovits M.(1889) Changes with aging in the levels of amino acids in rat CNS structural elements II. Taurine and small neutral amino acids. Neurochem Res 14:563–570.Google Scholar
  6. Bao J, Lei D, Du Y, Ohlemiller KK, Beaudet AL, Role LW (2005) Requirement of nicotinic acetylcholine receptor subunit β2 in the maintenance of spiral ganglion neurons during aging. J Neurosci 25:3041–3045.PubMedGoogle Scholar
  7. Barda G (2002) Rate of generation of oxidative stress–related damage and animal longevity. Free Radic Biol Med 33:1167–1172.Google Scholar
  8. Barker DJP (1998) In utero programming of chronic disease. Clin Sci 95:115–128.PubMedGoogle Scholar
  9. Barrenös M-L, Bratthall A, Dahlgren J (2003) The thrifty phenotype hypothesis and hearing problems. Br Med J 327:1199–1200.Google Scholar
  10. Barrenös M-L, Bratthall A, Dahlgren J (2005) The association between short stature and sensorineural hearing loss. Hear Res 205:123–130.Google Scholar
  11. Bohne BA, Gruner MM, Harding GW (1990) Morphological correlates of aging in the chinchilla cochlea. Hear Res 48:79–91.PubMedGoogle Scholar
  12. Bredberg G (1968) Cellular pattern and nerve supply of the human organ of Corti. Acta Otolaryngol (Suppl)236:1–135.Google Scholar
  13. Brimes M, Cerami A (2005) Emerging biological roles for erythropoietin in the nervous system. Nat Neurosci 6:484–494.Google Scholar
  14. Briner W, Willott JF (1989) Ultrastructural features of neurons in the CB57BL/6J mouse anteroventral cochlear nucleus: young mice versus old mice with chronic presbycusis. Neurobiol Aging 10:295–303.PubMedGoogle Scholar
  15. Brody H (1955) Organization of the cerebral cortex: III. A study of aging in the human cerebral cortex. J Comp Neurol 102:511–556.PubMedGoogle Scholar
  16. Cable J, Jackson IJ, Steel KP (1993) Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function, in the mouse inner ear. Pigment Cell Res 6:215–225.PubMedGoogle Scholar
  17. Canlon B, Erichsen S, Nemlander E, Chen M, Hossain A, Celsi G, Ceccatelli S (2003) Alterations in intrauterine environment by glucocorticoids modifies the developmental program of the auditory system. Eur J Neurosci 17:2035–2041.PubMedGoogle Scholar
  18. Carlsson P-I,VanLaer L, Borg E, Bondeson M-L, Thys M, Fransen E, Van Camp G (2005) The influence of genetic variation in oxidative stress genes on human noise susceptibility. Hear Res 202:87–96.PubMedGoogle Scholar
  19. Caspary DM, Raza A, Armour BAL, Pippin J, Arneric SP (1990) Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci 10:2363–2372.PubMedGoogle Scholar
  20. Caspary DM, Milbrandt, JC, Helfert RH (1995) Central auditory aging: GABA changes in the inferior colliculus. Exp Gerontol 30:349–360.PubMedGoogle Scholar
  21. Caspary DM, Holder TM, Hughes LF, Milbrandt JC, McKernan RM, Naritoku DK (1999) Age-related changes in GABA a receptor subunit composition and function in rat auditory system. Neuroscience 93:307–312.PubMedGoogle Scholar
  22. Caspary DM, Schatteman TA, Hughes, LF (2005) Age–related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs. J Neurosci 47:10952–10959.Google Scholar
  23. Chan DK, Hudspeth AJ (2005) Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro. Nat Neurosci 8:149–155.PubMedGoogle Scholar
  24. Chen MA, Webster P, Yang Y, Linthicum FH (2006) Presbycusic neuritic degeneration within the osseous spiral lamina. Otol Neurotol 27:316–322.PubMedGoogle Scholar
  25. Chisolm TH, Willott JF, Lister JJ (2003) The aging auditory system: anatomic and physiologic changes and implications for rehabilitation. Int J Audiol 42:2S3–2S10.PubMedGoogle Scholar
  26. Conlee JW, Gerrity LC, Bennett ML (1994) Ongoing proliferation of melanocytes in the stria vascularis of adult guinea pigs. Hear Res 79:115–122.PubMedGoogle Scholar
  27. Covell WP, Rogers JB (1957) Pathologic changes in the inner ear of senile guinea pigs. Laryngoscope 67:118–129.PubMedGoogle Scholar
  28. Crompton M (2004) Mitochondria and aging: a role for the permeability transition? Aging Cell 3:3–6.PubMedGoogle Scholar
  29. Cruickshanks KJ, Klein R, Klein BEK, T.L. W, Nondahl DM, Tweed TS (1998) Cigarette smoking and hearing loss. JAMA 279:1715–1719.Google Scholar
  30. Dai P, Yang W, Jiang S, Gu R, Yuan H, Han D, Guo W, Cao J (2004) Correlation of blood supply with mitochondrial DNA common deletion in presbycusis. Acta Otolaryngol 124:130–136.PubMedGoogle Scholar
  31. Davis RR, Newlander JK, Ling X–B, Cortopassi GA, Kreig EF, Erway LC (2001) Genetic basis for susceptibility to noise–induced hearing loss in mice. Hear Res 155:82–90.PubMedGoogle Scholar
  32. Davis RR, Kozel P, Erway LC (2003) Genetic influences in individual susceptibility to noise: a review. Noise Health 5:19–28.PubMedGoogle Scholar
  33. Delprat B, Ruel J, Guitton MJ, Hamard G, Lenoir M, Pujol R, Puel JL, Brabet P, Hamel CPJA (2005) Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin. Mol Cell Biol 25:847–853.PubMedGoogle Scholar
  34. Derin A, Agirdir B, Derin N, Dinc O, Guney K, Ozcaglar H, Kilincarslan S (2004) The effects of L–carnitine on presbycusis in the rat model. Clin Otolaryngol 29:238–241.PubMedGoogle Scholar
  35. Di Girolamo S, Quaranta N, Picciotti P, Torsello A, Wolf F (2001) Age-related histopathological changes of the stria vascularis: an experimental model. Audiology 40:322–326.PubMedGoogle Scholar
  36. Dirnagl U, Simon RP, Hallenbeck JM (2003) Ischemic tolerance and endogenous neuroprotection. Trends Neurosci 26:248–254.PubMedGoogle Scholar
  37. Drettner B, Hedstrand H, Klockhoff I, Svedberg A (1975) Cardiovascular risk factors and hearing loss. Acta Otolaryngol 79:366–371.PubMedGoogle Scholar
  38. Dunaway G, Mhaskar Y, Armour G, Whitworth C, Rybak LP (2003) Migration of cochlear lateral wall cells. Hear Res 177:1–11.PubMedGoogle Scholar
  39. Erway Lc, Willott JF, Archer JR, Harrison DE (1993) Genetics of age–related hearing loss in mice: I. Inbred and F1 hybrid strains. Hear Res 65:125–132.PubMedGoogle Scholar
  40. Erway LC, Shiau Y–W, Davis RR, Kreig EF (1996) Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hear Res 93:181–187.PubMedGoogle Scholar
  41. Fechter LD (2004) Promotion of noise–induced hearing loss by chemical contaminants. J Toxicol Appl Environ Health A 67:727–740.Google Scholar
  42. Felder E, Schrott-Fischer A (1995) Quantitative evaluation of myelinated nerve fibers in cochlea of humans with age-related high-tone hearing loss. Hear Res 91:19–32.PubMedGoogle Scholar
  43. Felder E, Kanonier G, Scholtz A, Rask-Andersen H, Schrott-Fischer A (1997) Quantitative evaluation of cochlear neurons and computer-aided three-dimensional reconstruction of spiral ganglion cells in humans with a peripheral loss of nerve fibers. Hear Res 105:183–190.PubMedGoogle Scholar
  44. Felix H, Pollak A, Gleeson MJ, Johnsson L–G (2002) Degeneration pattern of human first-order cochlear neurons. Adv Otorhinolaryngol 59:116–123.PubMedGoogle Scholar
  45. Fenech M (1998) Chromosomal damage rate, aging, and diet. Ann NY Acad Sci 854:23–26.PubMedGoogle Scholar
  46. Ferraro JA, Minckler J (1977) The human lateral lemniscus and its nuclei. Brain Lang 4:156–164.PubMedGoogle Scholar
  47. Fitzgibbons PJ, Gordon-Salant S (1996) Auditory temporal processing in elderly listeners. J Am Acad Audiol 7:183–189.Google Scholar
  48. Forge A, Schacht J (2000) Aminoglycoside antibiotics. Audiol Neuro-Otol 5:3–22.Google Scholar
  49. Fransen E, Lemkens N, Van Laer L, Van Camp G (2003) Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects. Exp Gerontol 38:353–359.PubMedGoogle Scholar
  50. Frisina RD (2001) Possible neurochemical and neuroanatomical bases of age-related hearing loss—presbycusis. Semin Hear 22:213–225.Google Scholar
  51. Frisina DR, Frisina RD (1997) Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res 106:95–104.PubMedGoogle Scholar
  52. Frisina RD, Walton JP (2001) Aging of the mouse central auditory system. In: Willott JP (ed) From Behavior to Molecular Biology. New York: CRC Press, pp. 339–379.Google Scholar
  53. Frisina RD, Walton JP (2006) Age-related structural and functional changes in the cochlear nucleus. Hear Res. 217:216–233.Google Scholar
  54. Frisina DR, Frisina RD, Snell KB, Burkard R, Walton JP, Ison JR (2001) Auditory temporal processing during aging. In: Hof PR, Mobbs CV (eds) Functional Neurobiology of Aging. San Diego: Academic Press, pp. 565–579.Google Scholar
  55. Frisina ST, Mapes F, Kim S-H, Frisina DR, Frisina RD (2006) Characterization of hearing loss in aged type II diabetics. Hear Res 211:103–113.PubMedGoogle Scholar
  56. Fukushima H, Cureoglu S, Schachern PA, Kusunoki T, Oktay MF, Fukushima N, Paparella MM, Harada T (2005) Cochlear changes in patients with type I diabetes mellitus. Otolaryngol Head Neck Surg 133:100–106.PubMedGoogle Scholar
  57. Gagnon PM, Simmons DD, Bao J, Lei D, Ortmann A, J., Ohlemiller KK (2007) Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice. Hear Res 226: 79–91.Google Scholar
  58. Garetz SL, Schacht J (1996) Ototoxicity: of mice and men. In: Van De Water TR, Popper AN, Fay RR (eds) Clinical Aspects of Hearing New York: Springer-Verlag, pp. 116–154.Google Scholar
  59. Gates GA, Mills JH (2005) Presbycusis. Lancet 366:1111–1120.PubMedGoogle Scholar
  60. Gates GA, Couropmitree NN, Myers RH (1999) Genetic associations in age–related hearing thresholds. Arch Otolaryngol Head Neck Surg 125:654–659.PubMedGoogle Scholar
  61. Geesaman BJ (2006) Genetics of aging: implications for drug discovery and development. Am J Clin Nutr 83:466S–469S.PubMedGoogle Scholar
  62. Gilad O, Glorig A (1979a) Presbycusis: The aging inner ear. Part I. J Am Audit Soc 4:195–206.Google Scholar
  63. Gilad O, Glorig A (1979b) Presbycusis: The aging ear. Part II. J Am Audit Soc 4:207–217.Google Scholar
  64. Glorig A, Wheeler D, Quiggle R, Grings W, Summerfeld A (1957) 1954 Wisconsin state fair hearing survey—statistical treatment of clinical and audiometric data. Am Acad Ophthalmol Otolaryngol (Monograph).Google Scholar
  65. Gordon-Salant S, Fitzgibbons PJ (1993) Temporal factors and speech recognition performance in young and elderly listeners. J Speech Hear Res 36:1272–1285.Google Scholar
  66. Gratton MA, Schulte BA (1995) Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils. Hear Res 82:44–52.PubMedGoogle Scholar
  67. Gratton MA, Schmiedt RA, Schulte BA (1996) Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis. Hear Res 102:181–190.PubMedGoogle Scholar
  68. Gratton MA, Smyth BJ, Lam CF, Boettcher FA, Schmiedt RA (1997) Decline in the endocochlear potential corresponds to decreased Na,K-ATPase activity in the lateral wall of quiet-aged gerbils. Hear Res 108:9–16.PubMedGoogle Scholar
  69. Hamernik RP, Patterson JH, Turrentine GA, Ahroon WA (1989) The quantitative relation between sensory cell loss and hearing thresholds. Hear Res 38:199–212.PubMedGoogle Scholar
  70. Hamernik RP, Qiu W, Davis B (2003) Cochlear toughening, protection, and potentiation of noise–induced hearing loss by non-Gaussian noise. J Acoust Soc Am 113:969–976.PubMedGoogle Scholar
  71. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:98–300.Google Scholar
  72. Harper JM, Wolf N, Galecki AT, Pinkosky SL, Miller RA (2003) Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice. Mech Ageing Dev 124:801–810.PubMedGoogle Scholar
  73. Harper JM, Galecki AT, Burke DT, Miller RA (2004) Body weight, hormones and T cell subsets as predictors of life span in genetically heterogeneous mice. Mech Ageing Dev 125:381–390.PubMedGoogle Scholar
  74. Harper JM, Durkee SJ, Smith-Wheelock M, Miller RA (2005) Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin in a long-lived mouse stock. Exp Gerontol 40:303–314.PubMedGoogle Scholar
  75. Harper JM, Salmon AB, Chang Y, Bonkowski M, Bartke A, Miller RA (2006) Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev 127:687–694.PubMedGoogle Scholar
  76. Hawkins JE, Johnsson L-G, Preston RE (1972) Cochlear microvasculature in normal and damaged ears. Laryngoscope 82:1091–1104.PubMedGoogle Scholar
  77. Helfert RD, Sommer TJ, Meeks J, Hofstetter P, Hughes L F (1999) Age-related synaptic changes in the central nucleus of the inferior colliculus of the Fischer-344 rat. J Comp Neurol 406:285–298.PubMedGoogle Scholar
  78. Helfert RD, Krenning J, Wilson TS, Hughes LF (2003) Age-related synaptic changes in the anteroventral cochlear nucleus of Fischer-344 rats. Hear Res 183:18–28.PubMedGoogle Scholar
  79. Henry KR, Chole RA (1980) Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology 19:369–383.PubMedGoogle Scholar
  80. Hequembourg S, Liberman MC (2001) Spiral ligament pathology: a major aspect of age-related cochlear degeneration in C57BL/6 mice. J Assoc Res Otolaryngol 2:118–129.PubMedGoogle Scholar
  81. Hirose K, Liberman MC (2003) Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea. J Assoc Res Otolaryngol 4:339–352.PubMedGoogle Scholar
  82. Hirose K, Discolo CM, Keasler JR, Ransohoff R (2005) Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma. J Comp Neurol 489:180–194.PubMedGoogle Scholar
  83. Hulbert AJ, Faulks SC, Harper JM, Miller RA, Buffenstein R (2006) Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes. Mech Ageing Dev 127:653–657.PubMedGoogle Scholar
  84. Ichimiya I, Suzuki M, Goro M (2000) Age-related changes in the murine cochlear lateral wall. Hear Res 139:116–122.PubMedGoogle Scholar
  85. Idrizbegovic E. Canlon B. Bross LS. Willott JF. Bogdanovic N (2001a) The total number of neurons and calcium binding protein positive neurons during aging in the cochlear nucleus of CBA/CaJ mice: a quantitative study. Hear Res 158:102–115.Google Scholar
  86. Idrizbegovic E, Viberg A, Bogdanovic N, Canlon B (2001b) Peripheral cell loss related to calcium binding protein immunocytochemistry in the dorsal cochlear nucleus in CBA/CaJ mice during aging. Audiol Neuro-Otol 6:132–139.Google Scholar
  87. Idrizbegovic E, Bogdanovic N, Viberg A, Canlon B (2003) Auditory peripheral influences on calcium binding protein immunoreactivity in the cochlear nucleus during aging in the C57BL/6J mouse. Hear Res 179:33–42.PubMedGoogle Scholar
  88. Idrizbegovic E. Bogdanovic N. Willott JF. Canlon B (2004) Age-related increases in calcium-binding protein immunoreactivity in the cochlear nucleus of hearing impaired C57BL/6J mice. Neurobiol Aging 25:1085–1093.PubMedGoogle Scholar
  89. Ishikawa T, Naito Y, Taniguchi K (1995) Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus. Diabetologia 38:649–655PubMedGoogle Scholar
  90. Jacobson M, KimS-H, Romney J, Zhu XX, Frisina RD (2003) Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners. Laryngoscope 113:1707–1713.Google Scholar
  91. Jerger J, Jordan C (1992) Age-related asymmetry on a cued-listening task. Ear Hear 13:272–277.PubMedGoogle Scholar
  92. Jerger J, Martin J (2004) Hemispheric asymmetry of the right ear advantage in dichotic listening. Hear Res 198:125–136.PubMedGoogle Scholar
  93. Jerger J, Chmiel R, Stach B, Spretnjak M (1993) Gender affects audiometric shape in presbycusis. J Am Acad Audiol 4:42–49.PubMedGoogle Scholar
  94. Jerger J, Chmiel R, Allen J, Wilson A (1994) Effects of age and gender on dichotic sentence identification. Ear Hear 15:274–286.PubMedGoogle Scholar
  95. Jerger J, Alford B, Lew H, Rivera V, Chmiel R (1995) Dichotic listening, event-related potentials, and interhemispheric transfer in the elderly. Ear Hear 16:482–498.PubMedGoogle Scholar
  96. Jiang H, Talaska AE, Schacht J, Sha S-H (2006) Oxidative imbalance in the aging inner ear. Neurobiol Aging 28: 1605–1612.PubMedGoogle Scholar
  97. Johnson KR, Zheng QY, Erway LC (2000) A major gene affecting age-related hearing loss is common to at least 10 inbred strains of mice. Genomics 70:171–180.PubMedGoogle Scholar
  98. Johnson KR, Zheng QY, Noben-Trauth K (2006) Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091:79–88.PubMedGoogle Scholar
  99. Johnsson L-G, Hawkins JE (1972) Strial atrophy in clinical and experimental deafness. Laryngoscope 82:1105–1125.PubMedGoogle Scholar
  100. Karasik D, Demissie S, Cupples AL, Kiel DP (2005) Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures. J Gerontol Biol Sci 60A:574–587.Google Scholar
  101. Keen EC, Hudspeth AJ (2006) Transfer characteristics of the hair cell’s afferent synapse. Proc Natl Acad Sci USA 103:5537–5542.Google Scholar
  102. Keithley, EM, Croskrey KL (1990) Spiral ganglion cell endings in the cochlear nucleus of young and old rats. Hear Res 49:169–177.PubMedGoogle Scholar
  103. Keithley EM, Feldman ML (1979) Spiral ganglion cell counts in an age-graded series of rat cochleas. J Comp Neurol 188:429–444.PubMedGoogle Scholar
  104. Keithley EM, Canto C, Zheng QY, Fischel-Ghodsian N, Johnson KR (2004) Age-related hearing loss and the ahl locus in mice. Hear Res 188:21–28.PubMedGoogle Scholar
  105. Keithley EM, Canto C, Zheng QY, Wang X, Fischel-Ghodsian N, Johnson KR (2005) Cu/Zn superoxide dismutase and age-related hearing loss. Hear Res 209:76–85.PubMedGoogle Scholar
  106. Kim S-H, Frisina DR, Frisina RD (2002) Effects of age on contralateral suppression of distortion-product otoacoustic emissions in human listeners with normal hearing. Audiol Neuro-Otol 7:348–357.Google Scholar
  107. Konigsmark BW, Murphy EA (1970) Neuronal populations in the human brain. Nature 228:1335–1336.PubMedGoogle Scholar
  108. Konigsmark BW, Murphy EA (1972) Volume of the ventral cochlear nucleus in man: Its relationship to neuronal population and age. J Neuropathol Exp Neurol 31:304–316.PubMedGoogle Scholar
  109. Krebs J (1998) The role of calcium in apoptosis. Biometals 11:375–382.PubMedGoogle Scholar
  110. Krenning J, Hughes L, Caspary D, Helfert, RH (1998) Age–related glycine receptor subunit changes in the cochlear nucleus of Fischer-344 rats. Laryngoscope 108:26–31.PubMedGoogle Scholar
  111. Kujawa SG, Liberman MC (2006) Acceleration of age–related hearing loss by early noise: Evidence of a misspent youth. J Neurosci 26:2115–2123.PubMedGoogle Scholar
  112. Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosisin mammalian aging. Science 309:481–484.PubMedGoogle Scholar
  113. Lambert PR, Schwartz IR (1982) A longitudinal study of changes in the cochlear nucleus in the CBA mouse. Otolaryngol Head Neck Surg 90:787–794.PubMedGoogle Scholar
  114. Lang H, Schulte BA, Schmiedt RA (2002) Endocochlear potentials and compound action potential recovery: functions in the C57BL/6J mouse. Hear Res 172:118–126.PubMedGoogle Scholar
  115. Lang H, Schulte BA, Schmiedt RA (2003) Effects of chronic furosemide treatment and age on cell division in the adult gerbil inner ear. J Assoc Res Otolaryngol 4:164–175.PubMedGoogle Scholar
  116. Lang H, Schulte BA, Zhou D, Smythe NM, Spicer SS, Schmiedt RA (2006a) Nuclear factor κB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss. J Neurosci 26:3541–3550.Google Scholar
  117. Lang H, Ebihara Y, Schmiedt RA, Minamiguchi H, Zhou D, Smythe N, M., Liu L, Ogawa M, Schulte BA (2006b) Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: mesenchymal cells and fibrocytes. J Comp Neurol 496:187–201.Google Scholar
  118. Le T, Keithley EM (2006) Effects of antioxidants on the aging inner ear. Hear Res 226: 194–202.PubMedGoogle Scholar
  119. Le Prell CG, Yamashita D, Minami SB, Yamasoba T, Miller JM (2006) Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res 226: 22–43.PubMedGoogle Scholar
  120. Leutner S, Eckert A, Muller WE (2001) ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J Neural Transm 108:955–967.PubMedGoogle Scholar
  121. Lu KP, Means AR (1993) Regulation of the cell cycle by calcium and calmodulin. Endocr Rev 14:40–58.PubMedGoogle Scholar
  122. Ma F, Gomez-Martin O, Lee DJ, Balkany T (1998) Diabetes and hearing impairment in Mexican American adults: A population-based study. J Laryngol Otol 112:835–839.PubMedGoogle Scholar
  123. Malpas S, Blake P, Bishop R, Robinson B, Johnson R (1989) Does autonomic neuropathy in diabetes cause hearing deficits? N Zeal Med J 102:434–435.Google Scholar
  124. Martin JS, Jerger JF (2005) Some effects of aging on central auditory processing. J Rehab Res Dev 42:25–44.Google Scholar
  125. McBride DJ, Williams S (2001) Audiometric notch as a sign of noise-induced hearing loss. Occup Environ Med 58:46–51.PubMedGoogle Scholar
  126. McFadden SL, Willott JF (1994) Responses of inferior colliculus neurons in C57BL/6J mice with and without sensorineural hearing loss: effects of changing the azimuthal location of an unmasked pure-tone stimulus. Hear Res 78:115–131.PubMedGoogle Scholar
  127. McFadden SL, Ding D, Reaume AG, Flood DG, Salvi RJ (1999) Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging 20:1–8.PubMedGoogle Scholar
  128. McFadden SL, Ding D-L, Ohlemiller KK, Salvi RJ (2001) The role of superoxide dismutase in age-related and noise-induced hearing loss: clues from Sod1 knockout mice. In: Willott JF (ed) From Behavior to Molecular Biology. New York: CRC Press, pp. 489–504.Google Scholar
  129. McGeer EGG, McGeer PL (1975) Age changes in the human for some enzymes associated with metabolism of catecholamines, GABA and acetylcholine. In: Ordy JM, Brizzee KR (eds) Neurobiology of Aging. New York: Plenum Press, pp. 287–305.Google Scholar
  130. Mikaelian DO, Warfield D, Norris O (1974) Genetic progressive hearing loss in the C57b16 mouse. Acta Otolaryngol 77:327–334.PubMedGoogle Scholar
  131. Milbrandt JC, Albin RL, Caspary DM (1994) Age-related decrease in GABAb receptor binding in the Fischer 344 rat inferior colliculus. Neurobiol Aging 15:699–703.PubMedGoogle Scholar
  132. Milbrandt JC, Caspary DM (1995) Age-related reduction of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. Neuroscience 67(3): 713–719.PubMedGoogle Scholar
  133. Milbrandt JC, Albin RL, Turgeon SM, Caspary DM (1996) GABAA receptor binding in the aging rat inferior colliculus. Neuroscience 73:449–458.PubMedGoogle Scholar
  134. Milbrandt JC, Hunter C, Caspary DM (1997) Alterations of GABAA receptor subunit mRNA levels in the aging Fischer rat inferior colliculus. J Comp Neurol 379:455–465.PubMedGoogle Scholar
  135. Miller RA, Chang Y, Galecki AT, Al-Regaiey K, Kopchick JJ, Bartke A (2002) Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol 16:2657–2666.PubMedGoogle Scholar
  136. Minowa O, Ikeda K, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Sugimoto T, Kikuchi T, Takasaka T, Noda T (1999) Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science 285:1408–1411.PubMedGoogle Scholar
  137. Nakashima T, Naganawa S, Sone M, Tominaga M, Hayashi H, Yamamoto H, Liu X, Nuttall AL (2003) Disorders of cochlear blood flow. Brain Res Rev 43:17–28.PubMedGoogle Scholar
  138. Niu X, Canlon B (2002) Protective mechanisms of sound conditioning. Adv Otorhinolaryngol 59:96–105.PubMedGoogle Scholar
  139. Nixon JC, Glorig A (1962) Changes in air and bone conduction threshoulds as a function of age. J Laryngol 76:288–298.Google Scholar
  140. Ohlemiller KK (2002) Reduction in sharpness of frequency tuning but not endocochlear potential in aging and noise-exposed BALB/cJ mice. J Assoc Res Otolaryngol 3:444–456.PubMedGoogle Scholar
  141. Ohlemiller KK (2003) Oxidative cochlear injury and the limitations of antioxidant therapy. Semin Hear 24:123–133.Google Scholar
  142. Ohlemiller KK (2006) Contributions of mouse models to understanding of age- and noise-related hearing loss. Brain Res 1091:89–102.PubMedGoogle Scholar
  143. Ohlemiller KK, Gagnon PM (2004a) Apical-to-basal gradients in age-related cochlear degeneration and their relationship to ‘primary’ loss of cochlear neurons. J Comp Neurol 479:103–116.Google Scholar
  144. Ohlemiller KK, Gagnon PM (2004b) Cellular correlates of progressive hearing loss in 129S6/SvEv mice. J Comp Neurol 469:377–390.Google Scholar
  145. Ohlemiller KK, McFadden SL, Ding D-L, Reaume AG, Hoffman EK, Scott RW, Wright JS, Putcha GV, Salvi RJ (1999) Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (SOD1) increases susceptibility to noise-induced hearing loss. Audiol Neuro-Otol 4:237–246.Google Scholar
  146. Ohlemiller KK, McFadden SL, Ding D-L, Lear PM, Ho Y-S (2000) Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol 1:243–254.PubMedGoogle Scholar
  147. Ohlemiller KK, Lett JM, Gagnon PM (2006) Cellular correlates of age-related endocochlear potential reduction in a mouse model. Hear Res 220:10–26.PubMedGoogle Scholar
  148. Ologe FE, Okoro EO, Oyejola BA (2005) Hearing function in Nigerian children with a family history of type II diabetes. Int J Pediatr Otorhinolaryngol 69:387–391.PubMedGoogle Scholar
  149. O’Neill WE, Zettel ML, Whittemore KR, Frisina RD (1997). Calbindin D-28k immunoreactivity in the medial nucleus of the trapezoid body declines with age in C57BL/6, but not CBA/CaJ, mice. Hear Res 112:158–166.PubMedGoogle Scholar
  150. Otte J, Schuknecht HF, Kerr AG (1978) Ganglion cell populations in normal and pathological human cochleae: Implications for cochlear implantation. Laryngoscope 38:1231–1246.Google Scholar
  151. Park JC, Cook KC, Verde EA (1990) Dietary restriction slows the abnormally rapid loss of spiral ganglion neurons in C57BL/6 mice. Hearing Res 48:275–280.Google Scholar
  152. Pauler M, Schuknecht HF, Thornton AR (1986) Correlative studies of cochlear neuronal loss with speech discrimination and pure-tone thresholds. Arch Otolaryngol 243:200–206.Google Scholar
  153. Pauler M, Schuknecht HF, White JA (1988) Atrophy of the stria vascularis as a cause of sensorineural hearing loss. Laryngoscope 98:754–759.PubMedGoogle Scholar
  154. Pekkonen E (2000) Mismatch negativity in aging and in Alzheimer’s and Parkinson’s diseases. Audiol Neuro-Otol 5:216–224.Google Scholar
  155. Pichora-Fuller MK (2003) Processing speed and timing in aging adults: psychoacoustics, speech perception, and comprehension. Int J Audiol (Suppl 1)42:S59–67.Google Scholar
  156. Pickles JO (2004) Mutation in mitochondrial DNA as a cause of presbyacusis. Audiol Neuro-Otol 9:23–33.Google Scholar
  157. Pillsbury HC (1986) Hypertension, hyperlipoproteinemia, chronic noise exposure: Is there synergism in cochlear pathology? Laryngoscope 96:1112–1138.PubMedGoogle Scholar
  158. Polich J, Howard L, Starr A (1985) Effects of age on the P300 component of the event–related potential from auditory stimuli: peak definition, variation, and measurement. J Gerontol 40:721–726.PubMedGoogle Scholar
  159. Prass K, Scharff A, Ruscher K, Lowl D, Muselmann C, Victorov I, Kapinya K, Dirnagl U, Meisel A (2003) Hypoxia-induced stroke tolerance in the mouse in mediated by erythropoietin. Stroke 34:1981–1986.PubMedGoogle Scholar
  160. Pujol R, Rebillard G, Puel J-L, Lenoir M, Eybalin M, Recasens M (1991) Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing. Acta Otolaryngol (Stockh) 476:32–36.Google Scholar
  161. Pujol R, Puel J-L, D’Aldin CG, Eybalin M (1993) Pathophysiology of the glutamate synapses of the cochlea. Acta Otolaryngol 113:330–334.PubMedGoogle Scholar
  162. Ran R, Xu H, Lu A, Bernaudin M, Sharp FR (2005) Hypoxic preconditioning in the brain. Dev Neurosci 27:87–92.PubMedGoogle Scholar
  163. Raynor EM, Carrasco VN, Prazma J, Pillsbury HC (1995) An assessment of cochlear hair-cell loss in insulin-dependent diabetes mellitus diabetic and noise-exposed rats. Arch Otolaryngol Head Neck Surg 121:452–456.PubMedGoogle Scholar
  164. Raza A, Milbrandt JC, Arneric SP, Caspary DM (1994) Age-related changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine functions. Hear Res 77:221–230.PubMedGoogle Scholar
  165. Rosen S, Olin P, Rosen HV (1970) Dietary prevention of hearing loss. Acta Otolaryngol 70:242–247.PubMedGoogle Scholar
  166. Rosen S, Bergman M, Plester D, El Mofti A, Satti M (1962) Presbycusis study of a relatively noise-free population in the Sudan. Ann Otol Rhinol Laryngol 71:727–742.PubMedGoogle Scholar
  167. Rosenhall U, Pedersen KE (1995) Presbycusis and occupational hearing loss. Occup Med 10:593–607.PubMedGoogle Scholar
  168. Rosenhall U, Sixt E, Sundh V, Svanborg A (1993) Correlations between presbycusis and extrinsic noxious factors. Audiology 32:234–243.PubMedGoogle Scholar
  169. Ruckenstein MJ, Milburn M, Hu L (1999a) Strial dysfunction in the MRL-Faslpr mouse. Otolaryngol Head Neck Surg 121:452–456.Google Scholar
  170. Ruckenstein MJ, Keithley EM, Bennett T, Powell HC, Baird S, Harris JP (1999b) Ultrastructural pathology in the stria vascularis of the MRL-Faslpr mouse. Hear Res 131:22–28.Google Scholar
  171. Rust KR, Prazma J, Triana RJ, Michaelis OEt, Pillsbury HC (1992) Inner ear damage secondary to diabetes mellitus. II. Changes in aging SHR/N-cp rats. Arch Otolaryngol Head Neck Surg 118:397–400.PubMedGoogle Scholar
  172. Saito T, Sato K, Saito H (1986) An experimental study of auditory dysfunction associated with hyperlipoproteinemia. Archives of Otorhinolaryngol 243:242–245.Google Scholar
  173. Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Murakami Y, Takeda T (1995) Age-related cochlear degeneration in senescence-accelerated mouse. Neurobiol Aging 16:129–136.PubMedGoogle Scholar
  174. Salvi RJ, Lockwood AH, Frisina RD, Coad ML, Wack DS, Frisina DR (2002) PET imaging of the normal human auditory system: responses to speech in quiet and in background noise. Hear Res 170:96–106.PubMedGoogle Scholar
  175. Sastre J, Pallardo FV, De La Asuncion JG, Vina J (2000) Mitochondria, oxidative stress and aging. Free Radic Res 32:189–198.PubMedGoogle Scholar
  176. Satar B, Ozkaptan Y, Surucu HS, Ozturk H (2001) Ultrastructural effects of hypercholesterolemia on the cochlea. Otol Neurotol 22:786–789.PubMedGoogle Scholar
  177. Schacht J, Hawkins JE (2005) Sketches of otohistory. Part 9: Presby[a]cusis. Audiol Neuro–Otol 10:243–247.Google Scholar
  178. Schmiedt RA, Lang H, Okamura H, Schulte BA (2002) Effects of furosemide applied chronically to the round window: A model of metabolic presbycusis. J Neuroscience 22:9643–9650.Google Scholar
  179. Schneider BA, Pichora-Fuller MK, Kowalchuk D, Lamb M (1994) Gap detection and the precedence effect in young and old adults. J Acoust Soc Am 95:980–991.PubMedGoogle Scholar
  180. Scholtz AW, Kammen-Jolly K, Felder E, Hussl B, Rask-Andersen H, Schrott-Fischer A (2001) Selective aspects of human pathology in high-tone hearing loss of the aging inner ear. Hear Res 157:77–86.PubMedGoogle Scholar
  181. Schuknecht HF (1953) Lesions of the organ of Corti. Trans Am Acad Ophthalmol Otolaryngol 57:366–383.PubMedGoogle Scholar
  182. Schuknecht HF (1964) Further observations on the pathology of presbycusis. Arch Otolaryngol 80:369–382.PubMedGoogle Scholar
  183. Schuknecht HF (1993) Pathology of the Ear, 2nd ed. Philadelphia: Lea and Febiger.Google Scholar
  184. Schuknecht HF, Gacek MR (1993) Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 102:1–16.PubMedGoogle Scholar
  185. Schuknecht HF, Watanuki K, Takahashi T, Belal AA, Kimura RS, Jones DD (1974) Atrophy of the stria vascularis, a common cause for hearing loss. Laryngoscope 84:1777–1821.PubMedGoogle Scholar
  186. Schulte BA, Schmiedt RA (1992) Lateral wall Na,K-ATPase and endocochlear potentials decline with age in quiet-reared gerbils. Hear Res 61:35–46.PubMedGoogle Scholar
  187. Schwaller B, Meyer M, Schiffmann S (2002) ‘New’ functions for ‘old’ proteins: the role of the calcium-binding proteins calbindin D-28K, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice. Cerebellum 1:241–258.PubMedGoogle Scholar
  188. Seidman MD (2000) Effects of dietary restriction and antioxidants on presbyacusis. Laryngoscope 110:727–738.PubMedGoogle Scholar
  189. Seidman MD, Ahmad N, Bai U (2002) Molecular mechanisms of age-related hearing loss. Ageing Res Rev 1:331–343.PubMedGoogle Scholar
  190. Seldon HL, Clark GM (1991) Human cochlear nucleus: comparison of Nissl-stained neurons from deaf and hearing patients. Brain Res 551:185–194.PubMedGoogle Scholar
  191. Shimada A, Ebisu M, Morita T, Takeuchi T, Umemura T (1998) Age-related changes in the cochlea and cochlear nuclei of dogs. J Vet Med Sci 60:41–48.PubMedGoogle Scholar
  192. Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Muller U (2004) Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 428:950–955.PubMedGoogle Scholar
  193. Sikora MA, Morizono T, Ward WD, Paparella MM, Leslie K (1986) Diet-induced hyperlipidemia and auditory dysfunction. Acta Otolaryngol 102:372–381.PubMedGoogle Scholar
  194. Sinclair DA (2005) Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126:987–1002.PubMedGoogle Scholar
  195. Snell KB, Frisina DR (2000). Relations among age-related differences in gap detection and speech perception. J. Acoust Soc Am 107: 1615–1626.PubMedGoogle Scholar
  196. Snell KB, Mapes FM, Hickman ED, Frisina DR (2002). Word recognition in competing babble and the effects of age, temporal processing, and absolute sensitivity. J Acoust Soc Am 112: 720–727.Google Scholar
  197. Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M (2007) Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging 28(10):1613–1622.PubMedGoogle Scholar
  198. Spencer JT (1973) Hyperlipoproteinemia in the etiology of inner ear disease. Laryngoscope 83:639–678.PubMedGoogle Scholar
  199. Spicer SS, Schulte BA (2002) Spiral ligament pathology in quiet-aged gerbils. Hear Res 172:172–185.PubMedGoogle Scholar
  200. Spicer SS, Schulte BA (2005) Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells. Hear Res 2005:225–240.Google Scholar
  201. Squier TC (2001) Oxidative stress and protein aggregation during biological aging. Exp Gerontol 36:1539–1550.PubMedGoogle Scholar
  202. Squier TC, Bigelow DJ (2000) Protein oxidation and age-dependent alterations in calcium homeostasis. Front Biosci 5:d504–526.PubMedGoogle Scholar
  203. Stamataki S, Francis HW, Lehar M, May BJ, Ryugo DK (2006) Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice. Hear Res 221:104–118.PubMedGoogle Scholar
  204. Starr A, Picton TW, Kim R (2001) Pathophysiology of auditory neuropathy. In: Sininger Y, Starr A (eds) Auditory Neuropathy: A New Perspective on Hearing Disorders San Diego: Singular, pp. 67–81.Google Scholar
  205. Suzuka Y, Schuknecht HF (1988) Retrograde cochlear neuronal degeneration in human subjects. Acta Otolaryngol Suppl 450:2–20.Google Scholar
  206. Suzuki K, Kaneko M, Murai K (2000) Influence of serum lipids on auditory function. Laryngoscope 110:1736–1738.PubMedGoogle Scholar
  207. Swartz KP, Walton JP, Crummer GC, Hantz EC, Frisina RD (1992) P3 event-related potentials and performance of healthy old and Alzheimer’s dementia subjects for music perception tasks. Psychomusicol 11: 96–118.Google Scholar
  208. Swartz KP, Walton JP, Hantz EC, Goldhammer E, Crummer GC, Frisina RD (1994) P3 event-related potentials and performance of young and old subjects for music perception tasks. Int J Neurosci 78:223–239.PubMedGoogle Scholar
  209. Sweet RJ, Price JM, Henry KR (1988) Dietary restriction and presbyacusis: periods of restriction and auditory threshold losses in the CBA/J mouse. Audiology 27:305–312.PubMedGoogle Scholar
  210. Tachibana M, Yamamichi I, Nakae S, Hirasugi Y, Machino M, Mizukoshi O (1984) The site of involvement of hypertension within the cochlea. Acta Otolaryngol 97:257–265.PubMedGoogle Scholar
  211. Tadros SF, Frisina ST, Mapes F, Kim S-H, Frisina DR, Frisina RD (2005a) Loss of peripheral right ear advantage in age-related hearing loss. Audiol Neuro-Otol, 10:44–52.Google Scholar
  212. Tadros SF, Frisina ST, Mapes F, Frisina DR, Frisina RD (2005b) Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis. Hear Res 209:10–18.Google Scholar
  213. Takumida M, Anniko A (2005) Radical scavengers: a remedy for presbycusis. A pilot study. Acta Otolaryngol 125:129–1293.Google Scholar
  214. Tarnowski BI, Schmiedt RA, Hellstrom LI, Lee FS, Adams JC (1991) Age-related changes in cochleae of Mongolian gerbils. Hear Res 54:123–134.PubMedGoogle Scholar
  215. Toescu EC (2005) Normal brain ageing: models and mechanisms. Philos Trans R Soc Lond B 360:2347–2354.Google Scholar
  216. Toppila E, Pyykko I, Starck J (2001) Age and noise-related hearing loss. Scand Audiol 30:236–244.PubMedGoogle Scholar
  217. Torre P, Cruickshanks KJ, Klein BEK, Nondahl DM (2005) The association between cardiovascular disease and cochlear function in older adults. J Speech Lang Hear Res 48:473–481.PubMedGoogle Scholar
  218. Trune DR, Kempton JB (2002) Female MRL.MpJ-Faslpr autoimmune mice have greater hearing loss than males. Hear Res 167:170–174.PubMedGoogle Scholar
  219. Trune DR, Kempton JB, Gross ND (2006) Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Hear Res 212:22–32.PubMedGoogle Scholar
  220. Uchida Y, Nakashima T, Ando F, Niino N, Shimokada H (2005) Is there a relevant effect of noise and smoking on hearing? A population-based aging study. Int J Audiol 44:86–91.PubMedGoogle Scholar
  221. Ulehlova L (1983) Stria vascularis in acoustic trauma. Arch Otorhinolaryngol 237:133–138.PubMedGoogle Scholar
  222. Unal M, Tamer L, Dogruer ZN, Yildirim H, Vayisoglu Y, Camdevirin H (2005) N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope 115:2238–2241.PubMedGoogle Scholar
  223. Varghese GI, Zhu XX, Frisina, RD (2005) Age-related declines in contralateral suppression of distortion product otoacoustic emissions utilizing pure tones in CBA/CaJ mice. Hear Res 209:60–67.PubMedGoogle Scholar
  224. Vaughan N, James K, McDermott D, Griest S, Fausti S (2005) A 5-year prospective study of diabetics and hearing loss in a veteran population. Otol Neurotol 27:37–43.Google Scholar
  225. von Zglinicki T, Martin-Ruiz CM (2005) Telomeres as biomarkers for aging and age–related disease. Curr Mol Med 5:197–203.Google Scholar
  226. Wackym PA, Linthicum FH (1986) Diabetes mellitus and hearing loss: clinical and histopathologic relationships. Am J Otol 7:176–182.PubMedGoogle Scholar
  227. Walton JP, Frisina RD, Ison JE, O’Neill WE (1997) Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse. J Comp Physiol A 181:161–176.PubMedGoogle Scholar
  228. Wang Y, Liberman MC (2002) Restraint stress and protection from acoustic injury in mice. Hear Res 165:96–102.PubMedGoogle Scholar
  229. Wang Y, Manis P B (2005) Synaptic transmission at the cochlear nucleus end bulb synapse during age-related hearing loss in mice. J Neurophysiol 94: 1814–1824.PubMedGoogle Scholar
  230. Wangemann P (2002) K+ recycling and the endocochlear potential. Hear Res 165:1–9.PubMedGoogle Scholar
  231. Whitlock NA, Agarwal N, Ma JX, Crosson CE (2005) Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats. Inv Ophthalmol Visual Sci 46:1092–1098.Google Scholar
  232. Willott JF (1991). Aging and the Auditory System: Anatomy, Physiology, and Psychophysics Sam Diego: Singular.Google Scholar
  233. Willott JF, Bross LS (1990) Morphology of the octopus cell area of the cochlear nucleus in young and aging C57BL/6J and CBA/J mice. J Comp Neurol 300:61–81.PubMedGoogle Scholar
  234. Willott JF, Bross LS (1996) Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA/2J and C57BL/6J mice. Dev Brain Res 91:218–226.Google Scholar
  235. Willott JF, Turner JG (1999) Prolonged exposure to an augmented acoustic environment ameliorates age-related auditory changes in C57BL/6J and DBA/2J mice. Hear Res 135:78–88.PubMedGoogle Scholar
  236. Willott JF, Jackson LM, Hunter KP (1987) Morphometric study of the anteroventral cochlear nucleus of two mouse models of presbycusis. J Comp Neurol 260:472–480.PubMedGoogle Scholar
  237. Willott JF, Parham K, Paris Hunter K (1991) Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice. Hear Res 53: 78–94.PubMedGoogle Scholar
  238. Willott JF, Bross LS, McFadden SL (1992) Morphology of the dorsal cochlear nucleus in C57BL/6J and CBA/J mice across the life span. J Comp Neurol 321:666–678.PubMedGoogle Scholar
  239. Willott JF, Milbrandt JC, Seegers Bross L, Caspary DM (1997) Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochlear impairment and aging. J Comp Neurol 385:405–414.PubMedGoogle Scholar
  240. Willott JF, Turner JG, Carlson S, Ding D, Bross LS, Falls WA (1998) The BALB/c mouse as an animal model for progressive sensorineural hearing loss. Hear Res 115:162–174.PubMedGoogle Scholar
  241. Wright CG, Schuknecht HF (1972) Atrophy of the spiral ligament. Arch Otolaryngol 96:16–21.PubMedGoogle Scholar
  242. Wu W-J, Sha S, McLaren JD, Kawamoto K, Raphael Y, Schacht J (2001) Aminoglycoside ototoxicity in adult CBA, C57BL, and BALB mice and the Sprague-Dawley rat. Hear Res 158:165–178.PubMedGoogle Scholar
  243. Xiu A–P, Kikuchi T, Minowa O, Katori Y, Oshima T, Noda T, Ikeda K (2002) Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses. Hear Res 166:150–158.Google Scholar
  244. Yamashita H, Shimogori H, Sugahara K, Takahashi M (1999) Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol 119:322–325.PubMedGoogle Scholar
  245. Yoshida N, Kristiansen A, Liberman MC (1999) Heat stress and protection from permanent acoustic injury in mice. J Neurosci 19:10116–10124.PubMedGoogle Scholar
  246. Zettel ML, Frisina RD, Haider SEA, O’Neill WE (1997) Age-related changes in calbindin D–28K and calretinin immunoreactivity in the inferior colliculus of CBA/CaJ and C57B1/6 mice. J Comp Neurol 386:92–110.PubMedGoogle Scholar
  247. Zettel ML, O’Neill WE, Trang TT, Frisina RD (2001) Early bilateral deafening prevents calretinin up-regulation in the dorsal cortex of the inferior colliculus of aged CBA/CaJ mice. Hear Res 158:131–138PubMedGoogle Scholar
  248. Zimmermann CE, Burgess BJ, Nadol JB (1995) Patterns of degeneration in the human cochlear nerve. Hear Res 90:192–201.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Kevin K. Ohlemiller
  • Robert D. Frisina

There are no affiliations available

Personalised recommendations