Autoimmune Inner Ear Disease

  • Quinton Gopen
  • Jeffrey P. Harris
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 31)


Hearing Loss Sensorineural Hearing Loss Stria Vascularis Vestibular Dysfunction Immune Complex Deposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berger P, Hillman M, Tabak M, Vollrath M (1991) The lymphocyte transformation test with type II collagen as a diagnostic tool of autoimmune sensorineural hearing loss. Laryngoscope 101:895–899.PubMedCrossRefGoogle Scholar
  2. Bieckert P (1961) On the problem of perception deafness and autoallergy. Z Laryngol Rhinol Otol 40:837–842.Google Scholar
  3. Broughton SS, Meyerhoff WE, Cohen SB (2004) Immune-mediated inner ear disease: 10-year experience. Semin Arthritis Rheum 34:544–548.PubMedCrossRefGoogle Scholar
  4. Clemis JD (1975) Allergy as a cause of fluctuant hearing loss. Otol Clin N Am 8: 375–383.Google Scholar
  5. Fukuda S, Harris JP, Keithley EM, Ishikawa K, Kucuk B, Inuyama Y (1992) Spiral modiolar vein: its importance in viral load of the inner ear. Ann Otol Rhinol Laryngol Suppl 157:67–71.PubMedGoogle Scholar
  6. Harris JP (1983) Immunology of the inner ear: response of the inner ear to antigen challenge. Otolaryngol Head Neck Surg 91:18–32.PubMedGoogle Scholar
  7. Harris JP (1984) Immunology of the inner ear: evidence of local antibody production. Ann Otol Rhinol Laryngol 93:157–162.PubMedGoogle Scholar
  8. Harris JP (1987) Experimental autoimmune sensorineural hearing loss. Laryngoscope 97:63–76.PubMedGoogle Scholar
  9. Harris JP (1989) Autoimmunity of the inner ear. Am J Otol 10:193–195.PubMedGoogle Scholar
  10. Harris JP, Keithley EM (2002) Autoimmune inner ear disease. In Snow JB, Ballenger JJ (eds) Otorhinolaryngology Head and Neck Surgery. Baltimore: BC Decker,pp. 396–407.Google Scholar
  11. Harris JP, Ryan AF (1984) Immunobiology of the inner ear. Am J Otolaryngol 5:418–425.PubMedCrossRefGoogle Scholar
  12. Harris JP, Fukuda S, Keithley EM (1990) Spiral modiolar vein: its importance in inner ear inflammation. Acta Otolaryngol 110:357–365.PubMedGoogle Scholar
  13. Harris JP, Heydt J, Keithley EM, Chen MC (1997) Immunopathology of the inner ear: an update. Ann NY Acad Sci 830:166–178.PubMedCrossRefGoogle Scholar
  14. Harris JP, Weisman WH, Derebery JM, Espeland MA, Gantz BJ, Gulya AS,Hammerschlag PE, Hannley M, et al. (2003) Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate: a randomized controlled trial. JAMA 290:1875–1883.PubMedCrossRefGoogle Scholar
  15. Hirose K, Wener MH, Duckert LG (1999) Utility of laboratory testing in autoimmune inner ear disease. Laryngoscope 109:1749–1754.PubMedCrossRefGoogle Scholar
  16. Hughes GB, Barna BP, Kinney SE, Calabrese LH, Nalepa NJ (1988) Clinical diagnosis of immune inner-ear disease. Laryngoscope 98:251–253.PubMedCrossRefGoogle Scholar
  17. Lehnhardt E (1958) Sudden hearing disorders occurring simultaneously or successively on both sides. Z Laryngol Rhinol Otol 37:1–16.PubMedGoogle Scholar
  18. Luetje CM, Berliner KI (1997) Plasmapharesis in autoimmune inner ear disease: long-term follow-up. Am J Otol 18:572–576.PubMedGoogle Scholar
  19. Ma C, Billings P, Harris JP, Keithley EM (2000) Characterization of an experimentally induced inner ear immune response. Laryngoscope 110:451–456.PubMedCrossRefGoogle Scholar
  20. Matteson EL, Choi HK, Poe DS, Wise C, Lowe VJ, McDonald TJ, and Rahman MU (2005) Etanercept therapy for immune-mediated cochleovestibular disorders: a multi-center, open-label, pilot study. Arthritis Rheum 53:337–342.PubMedCrossRefGoogle Scholar
  21. McCabe BF (1979) Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 88:585–589.PubMedGoogle Scholar
  22. Mogi G, Lim DJ, Watanabe N (1982) Immunologic study on the inner ear. Immunoglo- bulins in perilymph. Arch Otolaryngol 108:270–275.PubMedGoogle Scholar
  23. Moscicki RA, San Martin JE, Quintero CH, Rauch SD, Nadol JB Jr, and Bloch KJ. (1994) Serum antibody to inner ear proteins in patients with progressive hearing loss. JAMA 272:611–616.PubMedCrossRefGoogle Scholar
  24. Nair TS, Prieskorn DM, Miller JM, Mori A, Gray J and Carey TE. (1997) In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody. Hear Res 107:93–101.PubMedCrossRefGoogle Scholar
  25. Nair TS, Kozma KE, Hoefling NL, Kommareddi PK, Ueda Y, Gong TW, Lomax MI, Lansford CD, Telian SA, Satar B, Arts HA, EI-Kashlan HK, Berryhill WE, Raphael Y, Carey TE. (2004) Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci 24:1772–1779.PubMedCrossRefGoogle Scholar
  26. Niparko JK, Wang NY, Rauch SD, Russell GB, Espeland MA, Pierce JJ, Bowditch S, Masuda A, et al. (2005) Serial audiometry in a clinical trial of AIED treatment. Otol Neurotol 26:908–917.PubMedCrossRefGoogle Scholar
  27. Oppenheim JJ, Shecter B (1980) Lymphocyte transformation. In: Zachary AA, Braun WE (eds) Manual of Clinical Immunology, 2nd ed. Washington, DC: American Society Microbiology, pp. 233–245.Google Scholar
  28. Palva T, Raunio V (1967) Disc electrophoretic studies of human perilymph. Ann Otol Rhinol Laryngol 76:23–36.PubMedGoogle Scholar
  29. Rauch SD (1997) Clinical management of immune-mediated inner-ear disease. Ann NY Acad Sci 830:203–210.PubMedCrossRefGoogle Scholar
  30. Rocklin RE (1980) Production and assay of macrophage inhibitory factor. In: Zachary AA, Braun WE (eds) Manual of Clinical Immunology, 2nd ed. Washington, DC: American Society Microbiology, pp. 246–251.Google Scholar
  31. Ruckenstein MJ (2004) Autoimmune inner ear disease. Curr Opin Otolaryngol Head Neck Surg 12:426–430.PubMedGoogle Scholar
  32. Ryan AF, Gloddek B, Harris JP (1997) Lymphocyte trafficking to the inner ear. Ann NY Acad Sci 830:236–242.PubMedCrossRefGoogle Scholar
  33. Ryan AF, Harris JP, Keithley EM (2002) Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Suppl 548:38–43.PubMedCrossRefGoogle Scholar
  34. Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM (2003) Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation. J Assoc Res Otolaryngol 4:139–147.PubMedCrossRefGoogle Scholar
  35. Schiff M, Brown M (1974) Hormones and sudden deafness. Laryngoscope 84:1959–1981.PubMedGoogle Scholar
  36. Shin S, Billings P, Keithley E, Harris JP (1997) Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Ménière’s disease. Laryngoscope 107:222–227.PubMedCrossRefGoogle Scholar
  37. Suzuki M, Mogi G, Harris JP (1994) Expression of intercellular adhesion molecule-1 during inner ear inflammation. Ann Otol Rhinol Laryngol 104:69–75.Google Scholar
  38. Takahashi M, Harris JP (1988) Anatomic distribution and localization of immunocompetent cells in normal mouse endolymphatic sac. Acta Otolaryngol 106:409–416.PubMedCrossRefGoogle Scholar
  39. Takasu T, Harris JP (1997) Reduction of inner ear inflammation by treatment with anti-ICAM-1 antibody. Ann Otol Rhinol Laryngol 106:1070–1075.PubMedGoogle Scholar
  40. Tomiyama S, Harris JP (1986) The endolymphatic sac: its importance in inner ear immune responses. Laryngoscope 96:685–691.PubMedCrossRefGoogle Scholar
  41. van Wijk F, Staecker H, Keithley E, Lefebvre P (2006) Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol 11:357–365.PubMedCrossRefGoogle Scholar
  42. Veldman JE, Roord JJ, O’Connor AF, Shea JJ (1984) Autoimmunity and inner ear disorders: an immune-complex mediated sensorineural hearing loss. Laryngoscope 94:501–507.PubMedCrossRefGoogle Scholar
  43. Woolf NK, Harris JP, Ryan AF, Butler DM, and Richman DD. (1985) Hearing loss in experimental cytomegalovirus infection of the guinea pig inner ear: prevention by systemic immunity. Ann Otol Rhinol Laryngol 94:350–356.PubMedGoogle Scholar
  44. Yamanobe S, Harris JP, Keithley EM (1993) Evidence of direct communication of bone marrow cells with the endolymphatic sac in experimental autoimmune labyrinthitis. Acta Otolaryngol 113:166–170.PubMedCrossRefGoogle Scholar
  45. Yoo TJ, Tomoda K, Stuart JM, Cremer MA et al. (1983) Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. Ann Otol Rhinol Laryngol 92:267–271.PubMedGoogle Scholar
  46. Yoshihiko T, Yukihiro S (1964) Studies on experimental allergic (isoimmune) labyrinthitis in guinea pigs. Acta Otolaryngol 58:49–64.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Quinton Gopen
  • Jeffrey P. Harris

There are no affiliations available

Personalised recommendations