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Usual Interstitial Pneumonia

  • Chapter
Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

Abstract

Idiopathic pulmonary fibrosis (IPF), the most common and severe among idiopathic interstitial pneumonias, has now been definitively recognized as a distinct clinical entity, defined in the American Thoracic Society/European Respiratory Society (ATS/ERS) consensus statement as a specific form of chronic fibrosing interstitial pneumonia limited to the lung and associated with the histologic appearance of usual interstitial pneumonia (UIP) in surgical lung biopsy material.1–3 Thus, the precise definition of the “UIP” pattern is crucial for the diagnosis of IPF when histology is available and also for the understanding of the specific changes characterizing this devastating disease. The morphologic criteria for defining the UIP pattern have been progressively refined, from the seminal studies of Liebow to the recent ATS/ERS classification. It is worth noting that the different morphologic patterns that characterize the idiopathic interstitial pneumonias—UIP, nonspecific interstitial pneumonia (NSIP), acute interstitial pneumonia (AIP), cryptogenic organizing pneumonia (COP), lymphocytic interstitial pneumonia (LIP), desquamative interstitial pneumonia (DIP), and respiratory bronchiolitis-combined interstitial lung disease (RB-ILD)—have been progressively defined following a process of matching the clinical, radiologic, and morphologic features, using varying terms and criteria, in the absence of a precise knowledge of the etiology and pathogenesis of the different diseases.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Verona, Verona, Italy

    Marco Chilosi MD (Professor)

  2. Department of Anatomic Pathology, Regional Hospital, Mestre-Venice, Italy

    Bruno Murer MD

  3. Department of Diseases of the Thorax, Ospedale GB Morgagni, Forli, Italy

    Venerino Poletti MD, FCCP (Professor)

Authors
  1. Marco Chilosi MD
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  2. Bruno Murer MD
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  3. Venerino Poletti MD, FCCP
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Chilosi, M., Murer, B., Poletti, V. (2008). Usual Interstitial Pneumonia. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_55

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_55

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-72429-4

  • Online ISBN: 978-0-387-72430-0

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