Roles of Mutation and Epimutation in the Development of Lung Disease

  • William B. Coleman
Part of the Molecular Pathology Library book series (MPLB, volume 1)


The diseases of the lung reflect a spectrum of pathologies and mechanisms of pathogenesis spanning genetic, infectious, inflammatory, obstructive, and neoplastic processes. Gene mutations and other genetic alterations play a significant role in many lung diseases. Likewise, nongenetic alterations affecting the expression of key genes (epimutations) may also contribute to the genesis of lung disease. In this chapter, the molecular bases of the major lung diseases are reviewed. This review is not intended to be comprehensive. Rather, the current state of understanding related to the genes and molecular mechanisms (genetic and epigenetic) that contribute to major forms of lung disease (such as lung cancer) is discussed. For the interested reader, more complete reviews of specific topics are cited in the text.


Lung Cancer Chronic Obstructive Pulmonary Disease Small Cell Lung Cancer Human Lung Cancer Lung Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • William B. Coleman
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of North Carolina School of MedicineChapel HillUSA

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