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Stem Cells in Nonneoplastic Lung Disorders

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

Over the past decade, our knowledge regarding pulmonary stem cells has undergone dramatic expansion. Research has focused on (1) identifying and characterizing populations of resident pulmonary stem cells and (2) determining whether, and to what extent, bone marrow-derived stem cells contribute to pulmonary repair. It is hoped that the regenerative properties of stem cells can be harnessed to provide a new approach to treatment of diffuse lung diseases that are poorly responsive to current therapies. Acute respiratory distress syndrome is a prime example. Acute respiratory distress syndrome is associated with a mortality rate as high as 60% and leads to pulmonary disability in the majority of survivors. Whether stem cells could be utilized to promote recovery has been a topic of intense interest. Chronic obstructive pulmonary disease and usual interstitial pneumonia produce chronic lung dysfunction and, in their advanced forms, represent common indications for lung transplantation. Given the lack of curative therapies for these disorders, stem cell-based approaches have been viewed as a potential avenue for development.

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Authors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD (Professor and Chair)

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  1. Dani S. Zander MD
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Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Zander, D.S. (2008). Stem Cells in Nonneoplastic Lung Disorders. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_47

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_47

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