Stem Cells in Nonneoplastic Lung Disorders

  • Dani S. Zander
Part of the Molecular Pathology Library book series (MPLB, volume 1)


Over the past decade, our knowledge regarding pulmonary stem cells has undergone dramatic expansion. Research has focused on (1) identifying and characterizing populations of resident pulmonary stem cells and (2) determining whether, and to what extent, bone marrow-derived stem cells contribute to pulmonary repair. It is hoped that the regenerative properties of stem cells can be harnessed to provide a new approach to treatment of diffuse lung diseases that are poorly responsive to current therapies. Acute respiratory distress syndrome is a prime example. Acute respiratory distress syndrome is associated with a mortality rate as high as 60% and leads to pulmonary disability in the majority of survivors. Whether stem cells could be utilized to promote recovery has been a topic of intense interest. Chronic obstructive pulmonary disease and usual interstitial pneumonia produce chronic lung dysfunction and, in their advanced forms, represent common indications for lung transplantation. Given the lack of curative therapies for these disorders, stem cell-based approaches have been viewed as a potential avenue for development.


Stem Cell Side Population Cell Clara Cell Tracheal Epithelium Clara Cell Secretory Protein 


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© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Dani S. Zander
    • 1
  1. 1.Department of PathologyPenn State Milton S. Hershey Medical CenterHersheyUSA

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