Oxidants and Antioxidants

  • Hanzhong Liu
  • Gary A. Visner
Part of the Molecular Pathology Library book series (MPLB, volume 1)


Oxidants are an important source of injury to cells and tissues. The lung is exposed to significantly more oxidants than are most other organs. The lung is unique because of its large epithelial surface area that is directly exposed to high levels of oxygen tension, that is, oxygen pressure in inhaled air is 20 kPa (150 mm Hg). Ambient air contains additional oxidants, including cigarette smoke, asbestos fibers, mineral dust, and environmental carcinogens. A common component in most lung disease is activation of the inflammatory response, which leads to the generation of a relatively large quantity of oxidants. Even some therapeutic interventions, such as ventilation and oxygen therapy in the treatment of prematurely born neonates and acute respiratory distress syndrome, or chemotherapeutic agents, including bleomycin, carmustine, and anthracyclines, enhance oxidant burden to lung tissue.1 Thus, the lung represents a unique tissue exposed not only directly to external environmental oxidants under nor mal conditions but also to inflammation- and therapy-associated oxidants in disease state.


Respir Crit Reactive Nitrogen Species Exhale Breath Condensate Primary Pulmonary Hypertension Free Radic Biol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Hanzhong Liu
    • 1
  • Gary A. Visner
    • 2
  1. 1.Department of PediatricsChildren’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of PediatricsUniversity of Pennsylvania, Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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