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Parasites

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

In this chapter, I explore the advances made in understanding the molecular pathogenesis and basic immunologic principles of the most common protozoan and metazoan organisms that affect the lungs. These eukaryotic organisms are far more complex genetically than their bacterial and viral counterparts. Genome sizes range from 7,000 to 20,000 protein-encoding genes.1 This level of complexity is needed in order to survive through multiple stages of development that occur in intermediate and definitive hosts. As a rule, most parasitic diseases lead to chronicity, suggesting that the host-parasite relationship enters a level of “tolerance” that we are beginning to understand at the molecular level through a complex interaction between parasite-derived immunomodulatory products and the host immune response.

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Authors and Affiliations

  1. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

    Juan P. Olano MD (Associate Professor)

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  1. Juan P. Olano MD
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Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Olano, J.P. (2008). Parasites. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_42

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