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Molecular Pathology of Fungal Lung Infection

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

Fungi are eukaryotic, unicellular or multicellular organisms that are larger and genomically more complex than bacteria. The fungal cell wall is complex and has polysaccharides, proteins, sugars, and glycoproteins. Plasma membranes of fungi contain ergosterol, which is the primary target for antifungal drugs such as amphotericin B. Although more than 1.3 million fungal species exist in the environment, only about 150 are pathogenic to humans.1 The virulence factors of fungi resemble those of bacteria, such as possession of a capsule, adhesion molecules, toxins, free radicals, and so forth. Thus, fungi can elicit acute exudative, necrotizing, and granulomatous reactions in tissues. Although some generalizations are possible, the diverse structural and antigenic properties of individual fungi produce unique patterns of infection in individual hosts.2,5

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Authors and Affiliations

  1. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

    Michael R. McGinnis PhD (Professor) & Michael B. Smith MD

  2. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD (Professor, Chair and Director of Medical Laboratories)

  3. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD (Professor, Chair and Director of Medical Laboratories)

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  1. Michael R. McGinnis PhD
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  2. Michael B. Smith MD
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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McGinnis, M.R., Smith, M.B., Haque, A.K. (2008). Molecular Pathology of Fungal Lung Infection. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_41

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