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Primary Versus Metastatic Cancer: Gene Expression Profiling

  • Jaishree Jagirdar
  • Philip T. Cagle
Part of the Molecular Pathology Library book series (MPLB, volume 1)

Abstract

Accurate identification of the primary site of a cancer is important to predict prognosis and select appropriate therapy. Approximately 10%–15% of cancers initially present as metastases to solid organs, body cavities, or lymph nodes. However, the primary site of the metastatic cancer is not always clinically apparent. About 3%–5% of all cancers are carcinomas of unknown primary, making this type of tumor one of the 10 most frequent cancers in the world.1, 2, 3, 4, 5, 6, 7, 8, 9 Even with autopsy, in a series published in 2005 by Al-Brahim et al., a primary site was identified in only 51% of 53 cases of metastatic cancer of unknown origin.9

Keywords

Renal Cell Carcinoma Reverse Transcription Polymerase Chain Reaction Primary Lung Cancer Pseudomyxoma Peritonei Prostate Stem Cell Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Jaishree Jagirdar
    • 1
  • Philip T. Cagle
    • 2
    • 3
  1. 1.University of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Pathology and Laboratory MedicineWeill Medical College of Cornell UniversityNew York
  3. 3.The Methodist HospitalHoustonUSA

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