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Primary Versus Metastatic Cancer: Gene Expression Profiling

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

Accurate identification of the primary site of a cancer is important to predict prognosis and select appropriate therapy. Approximately 10%–15% of cancers initially present as metastases to solid organs, body cavities, or lymph nodes. However, the primary site of the metastatic cancer is not always clinically apparent. About 3%–5% of all cancers are carcinomas of unknown primary, making this type of tumor one of the 10 most frequent cancers in the world.1–9 Even with autopsy, in a series published in 2005 by Al-Brahim et al., a primary site was identified in only 51% of 53 cases of metastatic cancer of unknown origin.9

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Author information

Authors and Affiliations

  1. University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

    Jaishree Jagirdar MD (Professor, Department of Pathology, Director of Anatomic Pathology)

  2. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD (Professor and Director Pulmonary Pathology)

  3. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD (Professor and Director Pulmonary Pathology)

Authors
  1. Jaishree Jagirdar MD
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  2. Philip T. Cagle MD
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Jagirdar, J., Cagle, P.T. (2008). Primary Versus Metastatic Cancer: Gene Expression Profiling. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_33

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_33

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-72429-4

  • Online ISBN: 978-0-387-72430-0

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