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Posttransplantation Lymphoproliferative Disorder

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

Lymphoproliferative disorders are known complications of congenital and acquired immunodeficiency and/or iatrogenic-induced immunosuppression. A lymphoplasmacytic proliferation or lymphoma developing as a consequence of continuous iatrogenic immunosuppression following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) is called posttransplantation lymphoproliferative disorder (PTLD). Posttransplantation lymphoproliferative disorders are a morphologically and clinically heterogenous group of disorders, many of which are associated with the Epstein-Barr virus (EBV). Morphologically the spectrum ranges from polyclonal lymphoplasmacytic proliferations resembling infectious mononucleosis to frankly neoplastic lymphomas. These lymphomas are commonly EBV positive B cell and less commonly EBV negative (B or T cell) in origin. Clinically, some of these disorders regress after reduction of the immunosuppressive regimen, and others progress to serious and potentially fatal lymphomas requiring chemotherapy.

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Authors and Affiliations

  1. University of Texas Health Science Center at San Antonio and Audie L. Murphy VA Medical Center, San Antonio, TX, USA

    Aamir Ehsan MD (Associate Professor, Department of Pathology, Director of Molecular Diagnostics and Flow Cytometry)

  2. Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

    Jennifer L. Herrick MD (Hematopathology Fellow)

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  1. Aamir Ehsan MD
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Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Ehsan, A., Herrick, J.L. (2008). Posttransplantation Lymphoproliferative Disorder. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_31

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