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Cell Adhesion Molecules

  • Timothy Craig Allen
  • Philip T. Cagle
Part of the Molecular Pathology Library book series (MPLB, volume 1)

Abstract

Cell adhesion molecules, also termed cell adhesion receptors, are one of three classes of macromolecules—along with extracellular matrix molecules and adhesion plaque proteins—that mediate cell adhesion, an activity that is critical for the commencement and maintenance of the three-dimensional structure and normal function of tissues.1,2 Cell adhesion molecules are predominantly transmembrane glycoproteins that mediate binding to extracellular matrix molecules or to associated receptors on other cells in a manner that determines the specificity of cell-cell or cell-extracellular matrix interactions.1 There are five families of adhesion receptors—integrins, cadherins, immunoglobulin cell adhesion molecules (IgCAMs), selectins, and CD44.1,3, 4, 5, 6, 7 Complexes formed by cell adhesion receptors are not static, but are dynamic units capable of obtaining and incorporating extracellular environmental signals and are indeed the foundation of two-way signaling between the cell and its external environment.1,8 These cell adhesion molecule families are also involved in cell motility, migration, signaling, differentiation, apoptosis, and gene transcription.5

Keywords

Lung Cancer Epidermal Growth Factor Receptor Cell Adhesion Molecule Small Cell Lung Cancer Focal Adhesion Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Timothy Craig Allen
    • 1
  • Philip T. Cagle
    • 2
    • 3
  1. 1.Department of PathologyUniversity of Texas Health Center at TylerTylerUSA
  2. 2.Pathology and Laboratory MedicineWeill Medical College of Cornell UniversityNew York
  3. 3.The Methodist HospitalHoustonUSA

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