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Cell Adhesion Molecules

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

Cell adhesion molecules, also termed cell adhesion receptors, are one of three classes of macromolecules—along with extracellular matrix molecules and adhesion plaque proteins—that mediate cell adhesion, an activity that is critical for the commencement and maintenance of the three-dimensional structure and normal function of tissues.1,2 Cell adhesion molecules are predominantly transmembrane glycoproteins that mediate binding to extracellular matrix molecules or to associated receptors on other cells in a manner that determines the specificity of cell-cell or cell-extracellular matrix interactions.1 There are five families of adhesion receptors—integrins, cadherins, immunoglobulin cell adhesion molecules (IgCAMs), selectins, and CD44.1,3–7 Complexes formed by cell adhesion receptors are not static, but are dynamic units capable of obtaining and incorporating extracellular environmental signals and are indeed the foundation of two-way signaling between the cell and its external environment.1,8 These cell adhesion molecule families are also involved in cell motility, migration, signaling, differentiation, apoptosis, and gene transcription.5

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Authors and Affiliations

  1. Department of Pathology, University of Texas Health Center at Tyler, Tyler, TX, USA

    Timothy Craig Allen MD, JD

  2. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD (Professor and Director Pulmonary Pathology)

  3. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD (Professor and Director Pulmonary Pathology)

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  1. Timothy Craig Allen MD, JD
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  2. Philip T. Cagle MD
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Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Allen, T.C., Cagle, P.T. (2008). Cell Adhesion Molecules. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_3

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