Neuroendocrine Carcinomas and Precursors

  • Elisabeth Brambilla
Part of the Molecular Pathology Library book series (MPLB, volume 1)


Neuroendocrine lung tumors are usually classified into four histologic types that were shifted in the World Health Organization classification into three entities: small cell lung carcinoma (SCLC), large cell neuroendocrine carcinoma (LCNEC), and carcinoids (typical and atypical).1,2 This subset of tumors shares morphologic, ultrastructural, immunohistochemical, and molecular characteristics. The four main types neuroendocrine lung tumors show varying degrees of neuroendocrine morphologic features, and they behave according to three grades of clinical aggressivity, the low-grade typical carcinoids, the intermediate-grade atypical carcinoids, and the high-grade LCNECs and SCLCs, which share many features including epidemiologic growth factor and oncogenic pathways. However, the concept of a continuous spectrum from carcinoid to SCLC has no other scientific basis than a common neuroendocrine differentiation.


Vascular Endothelial Growth Factor Carcinoid Tumor Neuroendocrine Carcinoma Small Cell Lung Carcinoma Atypical Carcinoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Elisabeth Brambilla
    • 1
  1. 1.Department of Pathology, CHU de Grenoble Albert Michallon, Lung Cancer Research GroupINSERM U578GrenobleFrance

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