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Molecular Pathology of Squamous Cell Carcinoma and Its Precursors

  • Soon-Hee Jung
  • Bihong Zhao
  • Li Mao
  • Jae Y. Ro
Part of the Molecular Pathology Library book series (MPLB, volume 1)

Abstract

The normal respiratory mucosal epithelium at birth may undergo histologic changes during life due to exposure to a variety of environmental irritants, including tobacco smoke, radon exposure, and occupational toxins. Long-term carcinogenic insults may result in the development of multiple premalignant or malignant lesions in the respiratory epithelium. There is a wide spectrum of histopathologic changes in the respiratory epithelium, including hyperplastic lesions (basal cell hyperplasia/reserve cell hyperplasia), metaplastic lesions (primarily squamous metaplasia), dysplasia (mild, moderate, and severe), squamous cell carcinoma in situ, and invasive squamous cell carcinoma.1 The precursor lesions are also described as preneoplastic, premalignant, or preinvasive and are defined as epithelial abnormalities that are cytologically neoplastic but do not penetrate the basement membrane.2 These lesions have the capacity to progress to invasive carcinoma, to regress toward normal, or to remain indolent.3

Keywords

Epidermal Growth Factor Receptor Squamous Cell Carcinoma Small Cell Lung Cancer Epidermal Growth Factor Receptor Mutation Small Cell Lung Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Soon-Hee Jung
    • 1
  • Bihong Zhao
    • 2
  • Li Mao
    • 3
  • Jae Y. Ro
    • 4
  1. 1.Department of PathologyYonsei University/Wonju Christian HospitalWonju, Kangwon-DoKorea
  2. 2.Department of Pathology, Methodist Hospital, Weill Medical CollegeCornell UniversityHoustonUSA
  3. 3.Department of Thoracic and Head and Neck Medical OncologyUniversity of Texas MD Anderson Cancer CenterHoustonUSA
  4. 4.Department of PathologyCornell University/Methodist Hospital and University of Texas MD Anderson Cancer CenterHoustonUSA

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