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Viral Oncogenesis

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Molecular Pathology of Lung Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

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Abstract

For more than 100 years, researchers have suspected some tumors have an infectious etiology. In recent years, revelations regarding the origin of human cancers have come at an increasing pace. Infectious agents, mainly viruses, are among the few known causes of cancer and contribute to a variety of malignancies worldwide. In 1911, Peyton Rous successfully transmitted a malignancy from one chicken to another by injecting cell-free extracts from the tumor.1 His work signaled a new era in cancer research, and ultimately the cancer was shown to be caused by an RNA virus, the Rous sarcoma virus. Although scientists sporadically demonstrated the transmissibility of other tumors, the majority of attempts were unsuccessful. A renaissance of the viral hypothesis occurred in 1950 when Ludwik Gross discovered the transmissibility of murine leukemias by infecting newborn mice with tumor extracts.2 His work ushered in many additional studies, eventually leading to the discovery of several other viruses as causative factors of malignancy. In 1964, Epstein and colleagues observed herpesviruslike particles in cells of Burkitt’s lymphoma cell cultures.3

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, TX, USA

    Cindy Noel Berthelot MD

  2. Department of Dermatology, Microbiology/Molecular Genetics, and Internal Medicine, University of Texas Health Science Center, Houston, TX, USA

    Stephen K. Tyring MD, PhD, MBA (Professor)

Authors
  1. Cindy Noel Berthelot MD
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  2. Stephen K. Tyring MD, PhD, MBA
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Berthelot, C.N., Tyring, S.K. (2008). Viral Oncogenesis. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_24

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_24

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-72429-4

  • Online ISBN: 978-0-387-72430-0

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